| 1 | Sat 12 Sep 2020 | 70-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 2 | Wed 16 Sep 2020 | 70-2 v BrentfordSouthampton 0-2 Brentford | Carabao Cup Second Round |
| 3 | Sun 20 Sep 2020 | 72-5 v Tottenham HotspurSouthampton 2-5 Tottenham Hotspur | Premier League |
| 4 | Sun 4 Oct 2020 | 72-0 v West Bromwich AlbionSouthampton 2-0 West Bromwich Albion | Premier League |
| 5 | Sat 17 Oct 2020 | 73-3 v ChelseaChelsea 3-3 Southampton | Premier League |
| 6 | Sun 1 Nov 2020 | 74-3 v Aston VillaAston Villa 3-4 Southampton | Premier League |
| 7 | Fri 6 Nov 2020 | 72-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Premier League |
| 8 | Mon 23 Nov 2020 | 71-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton | Premier League |
| 9 | Sun 29 Nov 2020 | 72-3 v Manchester UnitedSouthampton 2-3 Manchester United | Premier League |
| 10 | Sat 26 Dec 2020 | 70-0 v FulhamFulham 0-0 Southampton | Premier League |
| 11 | Tue 29 Dec 2020 | 70-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 12 | Sat 16 Jan 2021 | 70-2 v Leicester CityLeicester City 2-0 Southampton | Premier League |
| 13 | Tue 19 Jan 2021 | 72-0 v Shrewsbury TownSouthampton 2-0 Shrewsbury Town | Emirates FA Cup Third Round |
| 14 | Sat 23 Jan 2021 | 71-0 v ArsenalSouthampton 1-0 Arsenal | Emirates FA Cup Fourth Round |
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