| 1 | Sun 20 Sep 2020 | 172-5 v Tottenham HotspurSouthampton 2-5 Tottenham Hotspur | Premier League |
| 2 | Sat 26 Sep 2020 | 171-0 v BurnleyBurnley 0-1 Southampton | Premier League |
| 3 | Sun 4 Oct 2020 | 172-0 v West Bromwich AlbionSouthampton 2-0 West Bromwich Albion | Premier League |
| 4 | Sun 25 Oct 2020 | 172-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 5 | Sun 1 Nov 2020 | 174-3 v Aston VillaAston Villa 3-4 Southampton | Premier League |
| 6 | Fri 6 Nov 2020 | 172-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Premier League |
| 7 | Mon 23 Nov 2020 | 171-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton | Premier League |
| 8 | Sun 29 Nov 2020 | 172-3 v Manchester UnitedSouthampton 2-3 Manchester United | Premier League |
| 9 | Mon 7 Dec 2020 | 172-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-2 Southampton | Premier League |
| 10 | Sun 13 Dec 2020 | 173-0 v Sheffield UnitedSouthampton 3-0 Sheffield United | Premier League |
| 11 | Wed 16 Dec 2020 | 171-1 v ArsenalArsenal 1-1 Southampton | Premier League |
| 12 | Sat 26 Dec 2020 | 170-0 v FulhamFulham 0-0 Southampton | Premier League |
| 13 | Tue 29 Dec 2020 | 170-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 14 | Mon 4 Jan 2021 | 171-0 v LiverpoolSouthampton 1-0 Liverpool | Premier League |
| 15 | Sat 16 Jan 2021 | 170-2 v Leicester CityLeicester City 2-0 Southampton | Premier League |
| 16 | Tue 19 Jan 2021 | 172-0 v Shrewsbury TownSouthampton 2-0 Shrewsbury Town | Emirates FA Cup Third Round |
| 17 | Sat 23 Jan 2021 | 171-0 v ArsenalSouthampton 1-0 Arsenal | Emirates FA Cup Fourth Round |
| 18 | Tue 26 Jan 2021 | 171-3 v ArsenalSouthampton 1-3 Arsenal | Premier League |
| 19 | Sat 30 Jan 2021 | 170-1 v Aston VillaSouthampton 0-1 Aston Villa | Premier League |
| 20 | Tue 2 Feb 2021 | 17 0-9 v Manchester UnitedManchester United 9-0 Southampton | Premier League |
| 21 | Thu 11 Feb 2021 | 172-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Southampton | Emirates FA Cup Fifth Round |
| 22 | Sun 14 Feb 2021 | 171-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 23 | Tue 23 Feb 2021 | 170-3 v Leeds UnitedLeeds United 3-0 Southampton | Premier League |
| 24 | Mon 1 Mar 2021 | 17 0-1 v EvertonEverton 1-0 Southampton | Premier League |
| 25 | Sat 6 Mar 2021 | 17 2-0 v Sheffield UnitedSheffield United 0-2 Southampton | Premier League |
| 26 | Wed 10 Mar 2021 | 172-5 v Manchester CityManchester City 5-2 Southampton | Premier League |
| 27 | Sun 14 Mar 2021 | 171-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 28 | Sat 20 Mar 2021 | 173-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 29 | Sun 4 Apr 2021 | 173-2 v BurnleySouthampton 3-2 Burnley | Premier League |
| 30 | Mon 12 Apr 2021 | 170-3 v West Bromwich AlbionWest Bromwich Albion 3-0 Southampton | Premier League |
| 31 | Sun 18 Apr 2021 | 170-1 v Leicester CityLeicester City 1-0 Southampton | Emirates FA Cup Semi Final |
| 32 | Wed 21 Apr 2021 | 171-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton | Premier League |
| 33 | Fri 30 Apr 2021 | 171-1 v Leicester CitySouthampton 1-1 Leicester City | Premier League |
| 34 | Sat 8 May 2021 | 170-2 v LiverpoolLiverpool 2-0 Southampton | Premier League |
| 35 | Tue 11 May 2021 | 173-1 v Crystal PalaceSouthampton 3-1 Crystal Palace | Premier League |
| 36 | Sat 15 May 2021 | 173-1 v FulhamSouthampton 3-1 Fulham | Premier League |
| 37 | Tue 18 May 2021 | 170-2 v Leeds UnitedSouthampton 0-2 Leeds United | Premier League |
| 38 | Sun 23 May 2021 | 170-3 v West Ham UnitedWest Ham United 3-0 Southampton | Premier League |
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