| 1 | 12/9/2020 | 440-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 2 | 16/9/2020 | 440-2 v BrentfordSouthampton 0-2 Brentford | Carabao Cup Second Round |
| 3 | 20/9/2020 | 442-5 v Tottenham HotspurSouthampton 2-5 Tottenham Hotspur | Premier League |
| 4 | 26/9/2020 | 441-0 v BurnleyBurnley 0-1 Southampton | Premier League |
| 5 | 4/10/2020 | 442-0 v West Bromwich AlbionSouthampton 2-0 West Bromwich Albion | Premier League |
| 6 | 17/10/2020 | 443-3 v ChelseaChelsea 3-3 Southampton | Premier League |
| 7 | 25/10/2020 | 442-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 8 | 1/11/2020 | 444-3 v Aston VillaAston Villa 3-4 Southampton | Premier League |
| 9 | 6/11/2020 | 442-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Premier League |
| 10 | 23/11/2020 | 441-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton | Premier League |
| 11 | 29/11/2020 | 442-3 v Manchester UnitedSouthampton 2-3 Manchester United | Premier League |
| 12 | 7/12/2020 | 442-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-2 Southampton | Premier League |
| 13 | 13/12/2020 | 443-0 v Sheffield UnitedSouthampton 3-0 Sheffield United | Premier League |
| 14 | 16/12/2020 | 441-1 v ArsenalArsenal 1-1 Southampton | Premier League |
| 15 | 19/12/2020 | 440-1 v Manchester CitySouthampton 0-1 Manchester City | Premier League |
| 16 | 26/12/2020 | 440-0 v FulhamFulham 0-0 Southampton | Premier League |
| 17 | 29/12/2020 | 440-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 18 | 4/1/2021 | 441-0 v LiverpoolSouthampton 1-0 Liverpool | Premier League |
| 19 | 16/1/2021 | 440-2 v Leicester CityLeicester City 2-0 Southampton | Premier League |
| 20 | 19/1/2021 | 442-0 v Shrewsbury TownSouthampton 2-0 Shrewsbury Town | Emirates FA Cup Third Round |
| 21 | 23/1/2021 | 441-0 v ArsenalSouthampton 1-0 Arsenal | Emirates FA Cup Fourth Round |
| 22 | 26/1/2021 | 441-3 v ArsenalSouthampton 1-3 Arsenal | Premier League |
| 23 | 30/1/2021 | 440-1 v Aston VillaSouthampton 0-1 Aston Villa | Premier League |
| 24 | 2/2/2021 | 440-9 v Manchester UnitedManchester United 9-0 Southampton | Premier League |
| 25 | 6/2/2021 | 442-3 v Newcastle UnitedNewcastle United 3-2 Southampton | Premier League |
| 26 | 11/2/2021 | 442-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Southampton | Emirates FA Cup Fifth Round |
| 27 | 14/2/2021 | 441-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 28 | 20/2/2021 | 441-1 v ChelseaSouthampton 1-1 Chelsea | Premier League |
| 29 | 23/2/2021 | 440-3 v Leeds UnitedLeeds United 3-0 Southampton | Premier League |
| 30 | 1/3/2021 | 440-1 v EvertonEverton 1-0 Southampton | Premier League |
| 31 | 6/3/2021 | 442-0 v Sheffield UnitedSheffield United 0-2 Southampton | Premier League |
| 32 | 10/3/2021 | 442-5 v Manchester CityManchester City 5-2 Southampton | Premier League |
| 33 | 14/3/2021 | 441-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 34 | 20/3/2021 | 443-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 35 | 4/4/2021 | 443-2 v BurnleySouthampton 3-2 Burnley | Premier League |
| 36 | 12/4/2021 | 440-3 v West Bromwich AlbionWest Bromwich Albion 3-0 Southampton | Premier League |
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