| 1 | 14/8/2021 | 441-3 v EvertonEverton 3-1 Southampton | Premier League |
| 2 | 22/8/2021 | 441-1 v Manchester UnitedSouthampton 1-1 Manchester United | Premier League |
| 3 | 25/8/2021 | 448-0 v Newport CountyNewport County 0-8 Southampton | Carabao Cup Second Round |
| 4 | 28/8/2021 | 442-2 v Newcastle UnitedNewcastle United 2-2 Southampton | Premier League |
| 5 | 11/9/2021 | 440-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 6 | 18/9/2021 | 440-0 v Manchester CityManchester City 0-0 Southampton | Premier League |
| 7 | 21/9/2021 | 442-2 v Sheffield UnitedSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 8 | 26/9/2021 | 440-1 v Wolverhampton WanderersSouthampton 0-1 Wolverhampton Wanderers | Premier League |
| 9 | 2/10/2021 | 441-3 v ChelseaChelsea 3-1 Southampton | Premier League |
| 10 | 16/10/2021 | 441-0 v Leeds UnitedSouthampton 1-0 Leeds United | Premier League |
| 11 | 23/10/2021 | 442-2 v BurnleySouthampton 2-2 Burnley | Premier League |
| 12 | 26/10/2021 | 44 1-1 v ChelseaChelsea 1-1 Southampton | Carabao Cup Round of 16 |
| 13 | 30/10/2021 | 441-0 v WatfordWatford 0-1 Southampton | Premier League |
| 14 | 5/11/2021 | 441-0 v Aston VillaSouthampton 1-0 Aston Villa | Premier League |
| 15 | 20/11/2021 | 441-2 v Norwich CityNorwich City 2-1 Southampton | Premier League |
| 16 | 27/11/2021 | 440-4 v LiverpoolLiverpool 4-0 Southampton | Premier League |
| 17 | 1/12/2021 | 442-2 v Leicester CitySouthampton 2-2 Leicester City | Premier League |
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