| 1 | Fri 6 Aug 2021 | 43-0 v VizelaSporting Lisbon 3-0 Vizela | Portuguese Primeira Liga |
| 2 | Sat 14 Aug 2021 | 4 2-1 v Sporting BragaSporting Braga 1-2 Sporting Lisbon | Portuguese Primeira Liga |
| 3 | Sat 21 Aug 2021 | 42-0 v BelenensesSporting Lisbon 2-0 Belenenses | Portuguese Primeira Liga |
| 4 | Sat 28 Aug 2021 | 41-1 v FamalicãoFamalicão 1-1 Sporting Lisbon | Portuguese Primeira Liga |
| 5 | Sat 11 Sep 2021 | 41-1 v FC PortoSporting Lisbon 1-1 FC Porto | Portuguese Primeira Liga |
| 6 | Sun 19 Sep 2021 | 41-0 v Estoril PraiaEstoril Praia 0-1 Sporting Lisbon | Portuguese Primeira Liga |
| 7 | Fri 24 Sep 2021 | 4 1-0 v MarítimoSporting Lisbon 1-0 Marítimo | Portuguese Primeira Liga |
| 8 | Tue 28 Sep 2021 | 40-1 v Borussia DortmundBorussia Dortmund 1-0 Sporting Lisbon | UEFA Champions League Group C |
| 9 | Sat 2 Oct 2021 | 42-1 v AroucaArouca 1-2 Sporting Lisbon | Portuguese Primeira Liga |
| 10 | Tue 19 Oct 2021 | 44-1 v BeşiktaşBeşiktaş 1-4 Sporting Lisbon | UEFA Champions League Group C |
| 11 | Sat 23 Oct 2021 | 41-0 v MoreirenseSporting Lisbon 1-0 Moreirense | Portuguese Primeira Liga |
| 12 | Sat 30 Oct 2021 | 41-0 v Vitória GuimarãesSporting Lisbon 1-0 Vitória Guimarães | Portuguese Primeira Liga |
| 13 | Wed 3 Nov 2021 | 44-0 v BeşiktaşSporting Lisbon 4-0 Beşiktaş | UEFA Champions League Group C |
| 14 | Sun 7 Nov 2021 | 42-0 v Paços de FerreiraPaços de Ferreira 0-2 Sporting Lisbon | Portuguese Primeira Liga |
| 15 | Wed 24 Nov 2021 | 4 3-1 v Borussia DortmundSporting Lisbon 3-1 Borussia Dortmund | UEFA Champions League Group C |
| 16 | Sun 28 Nov 2021 | 42-0 v TondelaSporting Lisbon 2-0 Tondela | Portuguese Primeira Liga |
| 17 | Sat 11 Dec 2021 | 42-0 v BoavistaSporting Lisbon 2-0 Boavista | Portuguese Primeira Liga |
| 18 | Sat 18 Dec 2021 | 4 3-0 v Gil VicenteGil Vicente 0-3 Sporting Lisbon | Portuguese Primeira Liga |
| 19 | Wed 29 Dec 2021 | 43-2 v PortimonenseSporting Lisbon 3-2 Portimonense | Portuguese Primeira Liga |
| 20 | Fri 7 Jan 2022 | 42-3 v Santa ClaraSanta Clara 3-2 Sporting Lisbon | Portuguese Primeira Liga |
| 21 | Sun 16 Jan 2022 | 4 2-0 v VizelaVizela 0-2 Sporting Lisbon | Portuguese Primeira Liga |
| 22 | Sat 22 Jan 2022 | 4 1-2 v Sporting BragaSporting Lisbon 1-2 Sporting Braga | Portuguese Primeira Liga |
| 23 | Sun 6 Feb 2022 | 42-0 v FamalicãoSporting Lisbon 2-0 Famalicão | Portuguese Primeira Liga |
| 24 | Fri 11 Feb 2022 | 4 2-2 v FC PortoFC Porto 2-2 Sporting Lisbon | Portuguese Primeira Liga |
| 25 | Tue 15 Feb 2022 | 40-5 v Manchester CitySporting Lisbon 0-5 Manchester City | UEFA Champions League Round of 16 |
| 26 | Sat 26 Feb 2022 | 41-1 v MarítimoMarítimo 1-1 Sporting Lisbon | Portuguese Primeira Liga |
| 27 | Sat 5 Mar 2022 | 4 2-0 v AroucaSporting Lisbon 2-0 Arouca | Portuguese Primeira Liga |
| 28 | Wed 9 Mar 2022 | 40-0 v Manchester CityManchester City 0-0 Sporting Lisbon | UEFA Champions League Round of 16 |
| 29 | Mon 14 Mar 2022 | 42-0 v MoreirenseMoreirense 0-2 Sporting Lisbon | Portuguese Primeira Liga |
| 30 | Sat 19 Mar 2022 | 43-1 v Vitória GuimarãesVitória Guimarães 1-3 Sporting Lisbon | Portuguese Primeira Liga |
| 31 | Sun 3 Apr 2022 | 42-0 v Paços de FerreiraSporting Lisbon 2-0 Paços de Ferreira | Portuguese Primeira Liga |
| 32 | Sat 9 Apr 2022 | 43-1 v TondelaTondela 1-3 Sporting Lisbon | Portuguese Primeira Liga |
| 33 | Sun 17 Apr 2022 | 40-2 v BenficaSporting Lisbon 0-2 Benfica | Portuguese Primeira Liga |
| 34 | Mon 25 Apr 2022 | 43-0 v BoavistaBoavista 0-3 Sporting Lisbon | Portuguese Primeira Liga |
| 35 | Sat 7 May 2022 | 4 3-2 v PortimonensePortimonense 2-3 Sporting Lisbon | Portuguese Primeira Liga |
| 36 | Sat 14 May 2022 | 44-0 v Santa ClaraSporting Lisbon 4-0 Santa Clara | Portuguese Primeira Liga |
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