| 1 | Sat 7 Aug 2021 | 43-2 v ReadingStoke City 3-2 Reading | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 40-0 v Birmingham CityBirmingham City 0-0 Stoke City | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 43-1 v Swansea CitySwansea City 1-3 Stoke City | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 41-0 v Nottingham ForestStoke City 1-0 Nottingham Forest | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 40-3 v FulhamFulham 3-0 Stoke City | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 4 2-1 v Huddersfield TownStoke City 2-1 Huddersfield Town | Sky Bet Championship |
| 7 | Wed 15 Sep 2021 | 41-1 v BarnsleyStoke City 1-1 Barnsley | Sky Bet Championship |
| 8 | Fri 1 Oct 2021 | 41-0 v West Bromwich AlbionStoke City 1-0 West Bromwich Albion | Sky Bet Championship |
| 9 | Sat 16 Oct 2021 | 41-2 v Sheffield UnitedSheffield United 2-1 Stoke City | Sky Bet Championship |
| 10 | Sat 23 Oct 2021 | 41-2 v MillwallMillwall 2-1 Stoke City | Sky Bet Championship |
| 11 | Sat 30 Oct 2021 | 43-3 v Cardiff CityStoke City 3-3 Cardiff City | Sky Bet Championship |
| 12 | Wed 3 Nov 2021 | 41-0 v BlackpoolBlackpool 0-1 Stoke City | Sky Bet Championship |
| 13 | Sat 6 Nov 2021 | 41-0 v Luton TownLuton Town 0-1 Stoke City | Sky Bet Championship |
| 14 | Sat 20 Nov 2021 | 4 2-0 v Peterborough UnitedStoke City 2-0 Peterborough United | Sky Bet Championship |
| 15 | Wed 24 Nov 2021 | 4 0-1 v Bristol CityBristol City 1-0 Stoke City | Sky Bet Championship |
| 16 | Sun 5 Dec 2021 | 42-0 v Queens Park RangersQueens Park Rangers 0-2 Stoke City | Sky Bet Championship |
| 17 | Sat 11 Dec 2021 | 40-0 v MiddlesbroughStoke City 0-0 Middlesbrough | Sky Bet Championship |
| 18 | Thu 30 Dec 2021 | 41-2 v Derby CountyStoke City 1-2 Derby County | Sky Bet Championship |
| 19 | Mon 3 Jan 2022 | 4 1-2 v Preston North EndStoke City 1-2 Preston North End | Sky Bet Championship |
| 20 | Sun 9 Jan 2022 | 42-0 v Leyton OrientStoke City 2-0 Leyton Orient | Emirates FA Cup Third Round |
| 21 | Sun 16 Jan 2022 | 42-0 v Hull CityHull City 0-2 Stoke City | Sky Bet Championship |
| 22 | Sat 22 Jan 2022 | 42-3 v FulhamStoke City 2-3 Fulham | Sky Bet Championship |
| 23 | Tue 25 Jan 2022 | 40-1 v Coventry CityCoventry City 1-0 Stoke City | Sky Bet Championship |
| 24 | Fri 28 Jan 2022 | 41-1 v Huddersfield TownHuddersfield Town 1-1 Stoke City | Sky Bet Championship |
| 25 | Sat 5 Feb 2022 | 42-0 v Wigan AthleticStoke City 2-0 Wigan Athletic | Emirates FA Cup Fourth Round |
| 26 | Tue 8 Feb 2022 | 43-0 v Swansea CityStoke City 3-0 Swansea City | Sky Bet Championship |
| 27 | Sat 12 Feb 2022 | 4 2-2 v Nottingham ForestNottingham Forest 2-2 Stoke City | Sky Bet Championship |
| 28 | Sat 19 Feb 2022 | 42-2 v Birmingham CityStoke City 2-2 Birmingham City | Sky Bet Championship |
| 29 | Wed 23 Feb 2022 | 41-2 v Luton TownStoke City 1-2 Luton Town | Sky Bet Championship |
| 30 | Sat 26 Feb 2022 | 41-2 v AFC BournemouthAFC Bournemouth 2-1 Stoke City | Sky Bet Championship |
| 31 | Tue 1 Mar 2022 | 41-2 v Crystal PalaceCrystal Palace 2-1 Stoke City | Emirates FA Cup Fifth Round |
| 32 | Tue 8 Mar 2022 | 41-1 v BarnsleyBarnsley 1-1 Stoke City | Sky Bet Championship |
| 33 | Sat 12 Mar 2022 | 4 2-2 v Peterborough UnitedPeterborough United 2-2 Stoke City | Sky Bet Championship |
| 34 | Wed 16 Mar 2022 | 41-2 v Cardiff CityCardiff City 2-1 Stoke City | Sky Bet Championship |
| 35 | Sat 19 Mar 2022 | 42-0 v MillwallStoke City 2-0 Millwall | Sky Bet Championship |
| 36 | Sat 2 Apr 2022 | 41-0 v Sheffield UnitedStoke City 1-0 Sheffield United | Sky Bet Championship |
| 37 | Tue 5 Apr 2022 | 41-2 v ReadingReading 2-1 Stoke City | Sky Bet Championship |
| 38 | Sat 9 Apr 2022 | 43-1 v West Bromwich AlbionWest Bromwich Albion 1-3 Stoke City | Sky Bet Championship |
| 39 | Fri 15 Apr 2022 | 40-1 v Bristol CityStoke City 0-1 Bristol City | Sky Bet Championship |
| 40 | Mon 18 Apr 2022 | 41-0 v Blackburn RoversBlackburn Rovers 0-1 Stoke City | Sky Bet Championship |
| 41 | Sat 23 Apr 2022 | 41-0 v Queens Park RangersStoke City 1-0 Queens Park Rangers | Sky Bet Championship |
| 42 | Sat 30 Apr 2022 | 41-3 v MiddlesbroughMiddlesbrough 3-1 Stoke City | Sky Bet Championship |
| 43 | Sat 7 May 2022 | 41-1 v Coventry CityStoke City 1-1 Coventry City | Sky Bet Championship |
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