| 1 | Sat 14 Aug 2021 | 52-4 v Paris St GermainParis St Germain 4-2 Strasbourg | French Ligue 1 |
| 2 | Sun 29 Aug 2021 | 53-1 v BrestStrasbourg 3-1 Brest | French Ligue 1 |
| 3 | Sun 12 Sep 2021 | 51-3 v LyonLyon 3-1 Strasbourg | French Ligue 1 |
| 4 | Wed 22 Sep 2021 | 51-0 v LensLens 0-1 Strasbourg | French Ligue 1 |
| 5 | Sat 2 Oct 2021 | 51-1 v MontpellierMontpellier 1-1 Strasbourg | French Ligue 1 |
| 6 | Sun 17 Oct 2021 | 55-1 v Saint ÉtienneStrasbourg 5-1 Saint Étienne | French Ligue 1 |
| 7 | Sun 31 Oct 2021 | 54-0 v LorientStrasbourg 4-0 Lorient | French Ligue 1 |
| 8 | Sun 21 Nov 2021 | 51-1 v ReimsStrasbourg 1-1 Reims | French Ligue 1 |
| 9 | Sun 28 Nov 2021 | 51-1 v MonacoMonaco 1-1 Strasbourg | French Ligue 1 |
| 10 | Wed 1 Dec 2021 | 55-2 v BordeauxStrasbourg 5-2 Bordeaux | French Ligue 1 |
| 11 | Sun 5 Dec 2021 | 53-0 v NiceNice 0-3 Strasbourg | French Ligue 1 |
| 12 | Sun 12 Dec 2021 | 50-2 v MarseilleStrasbourg 0-2 Marseille | French Ligue 1 |
| 13 | Sun 9 Jan 2022 | 52-0 v MetzMetz 0-2 Strasbourg | French Ligue 1 |
| 14 | Sun 16 Jan 2022 | 53-1 v MontpellierStrasbourg 3-1 Montpellier | French Ligue 1 |
| 15 | Wed 19 Jan 2022 | 52-0 v ClermontClermont 0-2 Strasbourg | French Ligue 1 |
| 16 | Sun 23 Jan 2022 | 53-4 v BordeauxBordeaux 4-3 Strasbourg | French Ligue 1 |
| 17 | Sun 6 Feb 2022 | 51-0 v NantesStrasbourg 1-0 Nantes | French Ligue 1 |
| 18 | Sun 13 Feb 2022 | 51-0 v AngersAngers 0-1 Strasbourg | French Ligue 1 |
| 19 | Sun 20 Feb 2022 | 5 2-2 v Saint ÉtienneSaint Étienne 2-2 Strasbourg | French Ligue 1 |
| 20 | Sat 26 Feb 2022 | 5 0-0 v NiceStrasbourg 0-0 Nice | French Ligue 1 |
| 21 | Sun 6 Mar 2022 | 51-1 v ReimsReims 1-1 Strasbourg | French Ligue 1 |
| 22 | Sun 13 Mar 2022 | 51-0 v MonacoStrasbourg 1-0 Monaco | French Ligue 1 |
| 23 | Sun 20 Mar 2022 | 5 0-0 v LorientLorient 0-0 Strasbourg | French Ligue 1 |
| 24 | Sun 10 Apr 2022 | 51-1 v LyonStrasbourg 1-1 Lyon | French Ligue 1 |
| 25 | Sun 17 Apr 2022 | 51-1 v TroyesTroyes 1-1 Strasbourg | French Ligue 1 |
| 26 | Wed 20 Apr 2022 | 52-1 v RennesStrasbourg 2-1 Rennes | French Ligue 1 |
| 27 | Sun 24 Apr 2022 | 5 0-1 v LilleLille 1-0 Strasbourg | French Ligue 1 |
| 28 | Fri 29 Apr 2022 | 53-3 v Paris St GermainStrasbourg 3-3 Paris St Germain | French Ligue 1 |
| 29 | Sat 21 May 2022 | 50-4 v MarseilleMarseille 4-0 Strasbourg | French Ligue 1 |
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