| 1 | Sun 15 Aug 2021 | 11-0 v Manchester CityTottenham Hotspur 1-0 Manchester City | Premier League |
| 2 | Sun 22 Aug 2021 | 11-0 v Wolverhampton WanderersWolverhampton Wanderers 0-1 Tottenham Hotspur | Premier League |
| 3 | Sun 29 Aug 2021 | 11-0 v WatfordTottenham Hotspur 1-0 Watford | Premier League |
| 4 | Sat 11 Sep 2021 | 10-3 v Crystal PalaceCrystal Palace 3-0 Tottenham Hotspur | Premier League |
| 5 | Sun 19 Sep 2021 | 10-3 v ChelseaTottenham Hotspur 0-3 Chelsea | Premier League |
| 6 | Sun 26 Sep 2021 | 11-3 v ArsenalArsenal 3-1 Tottenham Hotspur | Premier League |
| 7 | Sun 3 Oct 2021 | 12-1 v Aston VillaTottenham Hotspur 2-1 Aston Villa | Premier League |
| 8 | Sun 17 Oct 2021 | 13-2 v Newcastle UnitedNewcastle United 2-3 Tottenham Hotspur | Premier League |
| 9 | Sun 24 Oct 2021 | 10-1 v West Ham UnitedWest Ham United 1-0 Tottenham Hotspur | Premier League |
| 10 | Sat 30 Oct 2021 | 10-3 v Manchester UnitedTottenham Hotspur 0-3 Manchester United | Premier League |
| 11 | Thu 4 Nov 2021 | 13-2 v VitesseTottenham Hotspur 3-2 Vitesse | UEFA Europa Conference League |
| 12 | Sun 7 Nov 2021 | 10-0 v EvertonEverton 0-0 Tottenham Hotspur | Premier League |
| 13 | Sun 21 Nov 2021 | 12-1 v Leeds UnitedTottenham Hotspur 2-1 Leeds United | Premier League |
| 14 | Thu 2 Dec 2021 | 12-0 v BrentfordTottenham Hotspur 2-0 Brentford | Premier League |
| 15 | Sun 5 Dec 2021 | 13-0 v Norwich CityTottenham Hotspur 3-0 Norwich City | Premier League |
| 16 | Sun 19 Dec 2021 | 12-2 v LiverpoolTottenham Hotspur 2-2 Liverpool | Premier League |
| 17 | Wed 22 Dec 2021 | 12-1 v West Ham UnitedTottenham Hotspur 2-1 West Ham United | Carabao Cup Quarter Final |
| 18 | Sun 26 Dec 2021 | 13-0 v Crystal PalaceTottenham Hotspur 3-0 Crystal Palace | Premier League |
| 19 | Tue 28 Dec 2021 | 11-1 v SouthamptonSouthampton 1-1 Tottenham Hotspur | Premier League |
| 20 | Sat 1 Jan 2022 | 11-0 v WatfordWatford 0-1 Tottenham Hotspur | Premier League |
| 21 | Wed 5 Jan 2022 | 10-2 v ChelseaChelsea 2-0 Tottenham Hotspur | Carabao Cup Semi Final |
| 22 | Wed 19 Jan 2022 | 13-2 v Leicester CityLeicester City 2-3 Tottenham Hotspur | Premier League |
| 23 | Sun 23 Jan 2022 | 10-2 v ChelseaChelsea 2-0 Tottenham Hotspur | Premier League |
| 24 | Sat 5 Feb 2022 | 13-1 v Brighton & Hove AlbionTottenham Hotspur 3-1 Brighton & Hove Albion | Emirates FA Cup Fourth Round |
| 25 | Wed 9 Feb 2022 | 12-3 v SouthamptonTottenham Hotspur 2-3 Southampton | Premier League |
| 26 | Sun 13 Feb 2022 | 10-2 v Wolverhampton WanderersTottenham Hotspur 0-2 Wolverhampton Wanderers | Premier League |
| 27 | Sat 19 Feb 2022 | 1 3-2 v Manchester CityManchester City 2-3 Tottenham Hotspur | Premier League |
| 28 | Wed 23 Feb 2022 | 10-1 v BurnleyBurnley 1-0 Tottenham Hotspur | Premier League |
| 29 | Sat 26 Feb 2022 | 14-0 v Leeds UnitedLeeds United 0-4 Tottenham Hotspur | Premier League |
| 30 | Tue 1 Mar 2022 | 10-1 v MiddlesbroughMiddlesbrough 1-0 Tottenham Hotspur | Emirates FA Cup Fifth Round |
| 31 | Mon 7 Mar 2022 | 15-0 v EvertonTottenham Hotspur 5-0 Everton | Premier League |
| 32 | Sat 12 Mar 2022 | 12-3 v Manchester UnitedManchester United 3-2 Tottenham Hotspur | Premier League |
| 33 | Wed 16 Mar 2022 | 12-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-2 Tottenham Hotspur | Premier League |
| 34 | Sun 20 Mar 2022 | 13-1 v West Ham UnitedTottenham Hotspur 3-1 West Ham United | Premier League |
| 35 | Sun 3 Apr 2022 | 15-1 v Newcastle UnitedTottenham Hotspur 5-1 Newcastle United | Premier League |
| 36 | Sat 9 Apr 2022 | 14-0 v Aston VillaAston Villa 0-4 Tottenham Hotspur | Premier League |
| 37 | Sat 16 Apr 2022 | 10-1 v Brighton & Hove AlbionTottenham Hotspur 0-1 Brighton & Hove Albion | Premier League |
| 38 | Sat 23 Apr 2022 | 10-0 v BrentfordBrentford 0-0 Tottenham Hotspur | Premier League |
| 39 | Sun 1 May 2022 | 13-1 v Leicester CityTottenham Hotspur 3-1 Leicester City | Premier League |
| 40 | Sat 7 May 2022 | 11-1 v LiverpoolLiverpool 1-1 Tottenham Hotspur | Premier League |
| 41 | Thu 12 May 2022 | 13-0 v ArsenalTottenham Hotspur 3-0 Arsenal | Premier League |
| 42 | Sun 15 May 2022 | 1 1-0 v BurnleyTottenham Hotspur 1-0 Burnley | Premier League |
| 43 | Sun 22 May 2022 | 15-0 v Norwich CityNorwich City 0-5 Tottenham Hotspur | Premier League |
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