| 1 | Sat 7 Aug 2021 | 71-0 v WalsallTranmere Rovers 1-0 Walsall | Sky Bet League Two |
| 2 | Sat 14 Aug 2021 | 70-0 v Port ValePort Vale 0-0 Tranmere Rovers | Sky Bet League Two |
| 3 | Tue 17 Aug 2021 | 70-0 v Swindon TownSwindon Town 0-0 Tranmere Rovers | Sky Bet League Two |
| 4 | Sat 21 Aug 2021 | 70-1 v Newport CountyTranmere Rovers 0-1 Newport County | Sky Bet League Two |
| 5 | Sat 28 Aug 2021 | 70-1 v Scunthorpe UnitedScunthorpe United 1-0 Tranmere Rovers | Sky Bet League Two |
| 6 | Sat 4 Sep 2021 | 71-0 v Hartlepool UnitedTranmere Rovers 1-0 Hartlepool United | Sky Bet League Two |
| 7 | Sat 11 Sep 2021 | 70-1 v RochdaleRochdale 1-0 Tranmere Rovers | Sky Bet League Two |
| 8 | Sat 18 Sep 2021 | 72-0 v Salford CityTranmere Rovers 2-0 Salford City | Sky Bet League Two |
| 9 | Sat 25 Sep 2021 | 70-0 v Forest Green RoversForest Green Rovers 0-0 Tranmere Rovers | Sky Bet League Two |
| 10 | Sat 2 Oct 2021 | 72-1 v Crawley TownTranmere Rovers 2-1 Crawley Town | Sky Bet League Two |
| 11 | Fri 8 Oct 2021 | 72-0 v Colchester UnitedTranmere Rovers 2-0 Colchester United | Sky Bet League Two |
| 12 | Sat 16 Oct 2021 | 71-0 v Carlisle UnitedCarlisle United 0-1 Tranmere Rovers | Sky Bet League Two |
| 13 | Tue 19 Oct 2021 | 72-2 v Harrogate TownHarrogate Town 2-2 Tranmere Rovers | Sky Bet League Two |
| 14 | Sat 23 Oct 2021 | 70-2 v Northampton TownTranmere Rovers 0-2 Northampton Town | Sky Bet League Two |
| 15 | Sat 30 Oct 2021 | 70-2 v Mansfield TownMansfield Town 2-0 Tranmere Rovers | Sky Bet League Two |
| 16 | Tue 9 Nov 2021 | 73-2 v Oldham AthleticTranmere Rovers 3-2 Oldham Athletic | Papa John’s Trophy |
| 17 | Sat 13 Nov 2021 | 70-1 v Sutton UnitedTranmere Rovers 0-1 Sutton United | Sky Bet League Two |
| 18 | Sat 20 Nov 2021 | 72-2 v Bristol RoversBristol Rovers 2-2 Tranmere Rovers | Sky Bet League Two |
| 19 | Tue 23 Nov 2021 | 72-1 v Bradford CityTranmere Rovers 2-1 Bradford City | Sky Bet League Two |
| 20 | Sat 4 Dec 2021 | 70-4 v Leyton OrientLeyton Orient 4-0 Tranmere Rovers | Emirates FA Cup Second Round |
| 21 | Tue 7 Dec 2021 | 71-0 v Oldham AthleticOldham Athletic 0-1 Tranmere Rovers | Sky Bet League Two |
| 22 | Sat 11 Dec 2021 | 71-0 v Exeter CityExeter City 0-1 Tranmere Rovers | Sky Bet League Two |
| 23 | Sat 18 Dec 2021 | 71-0 v Leyton OrientTranmere Rovers 1-0 Leyton Orient | Sky Bet League Two |
| 24 | Sun 26 Dec 2021 | 72-0 v BarrowTranmere Rovers 2-0 Barrow | Sky Bet League Two |
| 25 | Sat 15 Jan 2022 | 72-0 v RochdaleTranmere Rovers 2-0 Rochdale | Sky Bet League Two |
| 26 | Sat 22 Jan 2022 | 71-0 v Crawley TownCrawley Town 0-1 Tranmere Rovers | Sky Bet League Two |
| 27 | Sat 29 Jan 2022 | 70-4 v Forest Green RoversTranmere Rovers 0-4 Forest Green Rovers | Sky Bet League Two |
| 28 | Tue 1 Feb 2022 | 71-0 v StevenageTranmere Rovers 1-0 Stevenage | Sky Bet League Two |
| 29 | Sat 5 Feb 2022 | 71-1 v BarrowBarrow 1-1 Tranmere Rovers | Sky Bet League Two |
| 30 | Tue 8 Feb 2022 | 73-0 v Swindon TownTranmere Rovers 3-0 Swindon Town | Sky Bet League Two |
| 31 | Sat 12 Feb 2022 | 70-1 v WalsallWalsall 1-0 Tranmere Rovers | Sky Bet League Two |
| 32 | Tue 15 Feb 2022 | 70-1 v Hartlepool UnitedHartlepool United 1-0 Tranmere Rovers | Sky Bet League Two |
| 33 | Sat 19 Feb 2022 | 7 1-1 v Port ValeTranmere Rovers 1-1 Port Vale | Sky Bet League Two |
| 34 | Sat 26 Feb 2022 | 72-4 v Newport CountyNewport County 4-2 Tranmere Rovers | Sky Bet League Two |
| 35 | Sat 5 Mar 2022 | 72-3 v Northampton TownNorthampton Town 3-2 Tranmere Rovers | Sky Bet League Two |
| 36 | Fri 11 Mar 2022 | 73-2 v Mansfield TownTranmere Rovers 3-2 Mansfield Town | Sky Bet League Two |
| 37 | Sat 2 Apr 2022 | 7 2-2 v Carlisle UnitedTranmere Rovers 2-2 Carlisle United | Sky Bet League Two |
| 38 | Sat 30 Apr 2022 | 72-0 v Oldham AthleticTranmere Rovers 2-0 Oldham Athletic | Sky Bet League Two |
| 39 | Sat 7 May 2022 | 71-0 v Leyton OrientLeyton Orient 0-1 Tranmere Rovers | Sky Bet League Two |
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