| 1 | Sat 11 Sep 2021 | 28 2-0 v Greuther FürthGreuther Fürth 0-2 VfL Wolfsburg | German Bundesliga |
| 2 | Tue 14 Sep 2021 | 280-0 v LilleLille 0-0 VfL Wolfsburg | UEFA Champions League Group G |
| 3 | Sun 19 Sep 2021 | 281-1 v Eintracht FrankfurtVfL Wolfsburg 1-1 Eintracht Frankfurt | German Bundesliga |
| 4 | Sat 25 Sep 2021 | 281-3 v 1899 Hoffenheim1899 Hoffenheim 3-1 VfL Wolfsburg | German Bundesliga |
| 5 | Wed 29 Sep 2021 | 281-1 v SevillaVfL Wolfsburg 1-1 Sevilla | UEFA Champions League Group G |
| 6 | Sat 2 Oct 2021 | 281-3 v Borussia MönchengladbachVfL Wolfsburg 1-3 Borussia Mönchengladbach | German Bundesliga |
| 7 | Sat 16 Oct 2021 | 280-2 v 1. FC Union Berlin1. FC Union Berlin 2-0 VfL Wolfsburg | German Bundesliga |
| 8 | Wed 20 Oct 2021 | 281-3 v SV Red Bull SalzburgSV Red Bull Salzburg 3-1 VfL Wolfsburg | UEFA Champions League Group G |
| 9 | Sat 23 Oct 2021 | 280-2 v SC FreiburgVfL Wolfsburg 0-2 SC Freiburg | German Bundesliga |
| 10 | Sat 30 Oct 2021 | 282-0 v Bayer 04 LeverkusenBayer 04 Leverkusen 0-2 VfL Wolfsburg | German Bundesliga |
| 11 | Tue 2 Nov 2021 | 282-1 v SV Red Bull SalzburgVfL Wolfsburg 2-1 SV Red Bull Salzburg | UEFA Champions League Group G |
| 12 | Sat 6 Nov 2021 | 281-0 v FC AugsburgVfL Wolfsburg 1-0 FC Augsburg | German Bundesliga |
| 13 | Sat 20 Nov 2021 | 282-2 v Arminia BielefeldArminia Bielefeld 2-2 VfL Wolfsburg | German Bundesliga |
| 14 | Tue 23 Nov 2021 | 280-2 v SevillaSevilla 2-0 VfL Wolfsburg | UEFA Champions League Group G |
| 15 | Sat 27 Nov 2021 | 28 1-3 v Borussia DortmundVfL Wolfsburg 1-3 Borussia Dortmund | German Bundesliga |
| 16 | Sat 4 Dec 2021 | 280-3 v Mainz 05Mainz 05 3-0 VfL Wolfsburg | German Bundesliga |
| 17 | Wed 8 Dec 2021 | 281-3 v LilleVfL Wolfsburg 1-3 Lille | UEFA Champions League Group G |
| 18 | Sat 11 Dec 2021 | 280-2 v VfB StuttgartVfL Wolfsburg 0-2 VfB Stuttgart | German Bundesliga |
| 19 | Tue 14 Dec 2021 | 282-3 v 1. FC KölnVfL Wolfsburg 2-3 1. FC Köln | German Bundesliga |
| 20 | Sat 15 Jan 2022 | 280-0 v Hertha BerlinVfL Wolfsburg 0-0 Hertha Berlin | German Bundesliga |
| 21 | Sun 23 Jan 2022 | 280-2 v RB LeipzigRB Leipzig 2-0 VfL Wolfsburg | German Bundesliga |
| 22 | Sat 12 Feb 2022 | 282-0 v Eintracht FrankfurtEintracht Frankfurt 0-2 VfL Wolfsburg | German Bundesliga |
| 23 | Sat 19 Feb 2022 | 281-2 v 1899 HoffenheimVfL Wolfsburg 1-2 1899 Hoffenheim | German Bundesliga |
| 24 | Sun 3 Apr 2022 | 280-3 v FC AugsburgFC Augsburg 3-0 VfL Wolfsburg | German Bundesliga |
| 25 | Sat 7 May 2022 | 281-0 v 1. FC Köln1. FC Köln 0-1 VfL Wolfsburg | German Bundesliga |
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