| 1 | Sun 15 Aug 2021 | 271-0 v PEC ZwollePEC Zwolle 0-1 Vitesse | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 270-3 v Willem IIVitesse 0-3 Willem II | Dutch Eredivisie |
| 3 | Thu 16 Sep 2021 | 272-0 v Mura Murska SobotaMura Murska Sobota 0-2 Vitesse | UEFA Europa Conference League |
| 4 | Sun 24 Oct 2021 | 271-2 v Go Ahead EaglesVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 5 | Sat 20 Nov 2021 | 270-2 v PSV EindhovenPSV Eindhoven 2-0 Vitesse | Dutch Eredivisie |
| 6 | Thu 25 Nov 2021 | 273-3 v RennesRennes 3-3 Vitesse | UEFA Europa Conference League |
| 7 | Sun 12 Dec 2021 | 272-1 v Heracles AlmeloVitesse 2-1 Heracles Almelo | Dutch Eredivisie |
| 8 | Sat 18 Dec 2021 | 272-2 v Sparta RotterdamSparta Rotterdam 2-2 Vitesse | Dutch Eredivisie |
| 9 | Sat 5 Feb 2022 | 270-3 v FC TwenteFC Twente 3-0 Vitesse | Dutch Eredivisie |
| 10 | Thu 24 Feb 2022 | 272-0 v Rapid ViennaVitesse 2-0 Rapid Vienna | UEFA Europa Conference League |
| 11 | Sat 2 Apr 2022 | 271-3 v AZ AlkmaarAZ Alkmaar 3-1 Vitesse | Dutch Eredivisie |
| 12 | Sun 1 May 2022 | 272-1 v Go Ahead EaglesGo Ahead Eagles 1-2 Vitesse | Dutch Eredivisie |
| 13 | Wed 11 May 2022 | 272-1 v Fortuna SittardFortuna Sittard 1-2 Vitesse | Dutch Eredivisie |
| 14 | Sun 15 May 2022 | 272-2 v AjaxVitesse 2-2 Ajax | Dutch Eredivisie |
| 15 | Sun 22 May 2022 | 273-0 v FC UtrechtVitesse 3-0 FC Utrecht | Dutch Eredivisie Play-off |
| 16 | Thu 26 May 2022 | 272-1 v AZ AlkmaarVitesse 2-1 AZ Alkmaar | Dutch Eredivisie Play-off |
| 17 | Sun 29 May 2022 | 271-6 v AZ AlkmaarAZ Alkmaar 6-1 Vitesse | Dutch Eredivisie Play-off |
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