| 1 | 15/8/2021 | 81-0 v PEC ZwollePEC Zwolle 0-1 Vitesse | Dutch Eredivisie |
| 2 | 22/8/2021 | 80-3 v Willem IIVitesse 0-3 Willem II | Dutch Eredivisie |
| 3 | 26/8/2021 | 82-1 v RSC AnderlechtVitesse 2-1 RSC Anderlecht | UEFA Europa Conference League |
| 4 | 29/8/2021 | 80-5 v AjaxAjax 5-0 Vitesse | Dutch Eredivisie |
| 5 | 12/9/2021 | 82-1 v RKC WaalwijkRKC Waalwijk 1-2 Vitesse | Dutch Eredivisie |
| 6 | 16/9/2021 | 82-0 v Mura Murska SobotaMura Murska Sobota 0-2 Vitesse | UEFA Europa Conference League |
| 7 | 19/9/2021 | 81-4 v FC TwenteVitesse 1-4 FC Twente | Dutch Eredivisie |
| 8 | 22/9/2021 | 81-0 v FC GroningenFC Groningen 0-1 Vitesse | Dutch Eredivisie |
| 9 | 25/9/2021 | 81-1 v Fortuna SittardVitesse 1-1 Fortuna Sittard | Dutch Eredivisie |
| 10 | 30/9/2021 | 8 1-2 v RennesVitesse 1-2 Rennes | UEFA Europa Conference League |
| 11 | 3/10/2021 | 82-1 v FeyenoordVitesse 2-1 Feyenoord | Dutch Eredivisie |
| 12 | 17/10/2021 | 8 1-0 v NEC NijmegenNEC Nijmegen 0-1 Vitesse | Dutch Eredivisie |
| 13 | 21/10/2021 | 81-0 v Tottenham HotspurVitesse 1-0 Tottenham Hotspur | UEFA Europa Conference League |
| 14 | 24/10/2021 | 8 1-2 v Go Ahead EaglesVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 15 | 30/10/2021 | 8 2-1 v sc Heerenveensc Heerenveen 1-2 Vitesse | Dutch Eredivisie |
| 16 | 4/11/2021 | 82-3 v Tottenham HotspurTottenham Hotspur 3-2 Vitesse | UEFA Europa Conference League |
| 17 | 7/11/2021 | 82-1 v FC UtrechtVitesse 2-1 FC Utrecht | Dutch Eredivisie |
| 18 | 20/11/2021 | 80-2 v PSV EindhovenPSV Eindhoven 2-0 Vitesse | Dutch Eredivisie |
| 19 | 25/11/2021 | 83-3 v RennesRennes 3-3 Vitesse | UEFA Europa Conference League |
| 20 | 28/11/2021 | 80-0 v AZ AlkmaarVitesse 0-0 AZ Alkmaar | Dutch Eredivisie |
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