| 1 | Sat 14 Aug 2021 | 11 1-0 v Rotherham UnitedWigan Athletic 1-0 Rotherham United | Sky Bet League One |
| 2 | Tue 17 Aug 2021 | 111-1 v Wycombe WanderersWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 3 | Sat 21 Aug 2021 | 112-0 v Charlton AthleticCharlton Athletic 0-2 Wigan Athletic | Sky Bet League One |
| 4 | Tue 24 Aug 2021 | 110-0 v Bolton WanderersWigan Athletic 0-0 Bolton Wanderers | Carabao Cup Second Round |
| 5 | Sat 28 Aug 2021 | 111-0 v PortsmouthWigan Athletic 1-0 Portsmouth | Sky Bet League One |
| 6 | Tue 21 Sep 2021 | 110-2 v SunderlandWigan Athletic 0-2 Sunderland | Carabao Cup Third Round |
| 7 | Sat 25 Sep 2021 | 112-0 v Cheltenham TownWigan Athletic 2-0 Cheltenham Town | Sky Bet League One |
| 8 | Sat 2 Oct 2021 | 11 2-0 v GillinghamGillingham 0-2 Wigan Athletic | Sky Bet League One |
| 9 | Tue 5 Oct 2021 | 110-2 v Crewe AlexandraCrewe Alexandra 2-0 Wigan Athletic | Papa John’s Trophy |
| 10 | Sat 16 Oct 2021 | 11 4-0 v Bolton WanderersBolton Wanderers 0-4 Wigan Athletic | Sky Bet League One |
| 11 | Tue 19 Oct 2021 | 111-2 v Milton Keynes DonsWigan Athletic 1-2 Milton Keynes Dons | Sky Bet League One |
| 12 | Sat 23 Oct 2021 | 112-0 v AFC WimbledonAFC Wimbledon 0-2 Wigan Athletic | Sky Bet League One |
| 13 | Tue 26 Oct 2021 | 111-2 v Lincoln CityWigan Athletic 1-2 Lincoln City | Sky Bet League One |
| 14 | Sat 30 Oct 2021 | 112-0 v Burton AlbionWigan Athletic 2-0 Burton Albion | Sky Bet League One |
| 15 | Wed 10 Nov 2021 | 112-0 v Shrewsbury TownWigan Athletic 2-0 Shrewsbury Town | Papa John’s Trophy |
| 16 | Tue 16 Nov 2021 | 112-1 v Solihull MoorsSolihull Moors 1-2 Wigan Athletic | Emirates FA Cup First Round Replay |
| 17 | Tue 23 Nov 2021 | 112-2 v Cambridge UnitedCambridge United 2-2 Wigan Athletic | Sky Bet League One |
| 18 | Sat 27 Nov 2021 | 112-1 v Plymouth ArgylePlymouth Argyle 1-2 Wigan Athletic | Sky Bet League One |
| 19 | Sun 5 Dec 2021 | 112-1 v Colchester UnitedColchester United 1-2 Wigan Athletic | Emirates FA Cup Second Round |
| 20 | Wed 8 Dec 2021 | 112-1 v Shrewsbury TownWigan Athletic 2-1 Shrewsbury Town | Sky Bet League One |
| 21 | Sat 11 Dec 2021 | 111-1 v Ipswich TownWigan Athletic 1-1 Ipswich Town | Sky Bet League One |
| 22 | Sat 18 Dec 2021 | 113-2 v Oxford UnitedOxford United 2-3 Wigan Athletic | Sky Bet League One |
| 23 | Tue 4 Jan 2022 | 116-0 v Oldham AthleticOldham Athletic 0-6 Wigan Athletic | Papa John’s Trophy Third Round |
| 24 | Sat 8 Jan 2022 | 113-2 v Blackburn RoversWigan Athletic 3-2 Blackburn Rovers | Emirates FA Cup Third Round |
| 25 | Sat 15 Jan 2022 | 112-1 v Doncaster RoversDoncaster Rovers 1-2 Wigan Athletic | Sky Bet League One |
| 26 | Tue 18 Jan 2022 | 112-1 v MorecambeMorecambe 1-2 Wigan Athletic | Sky Bet League One |
| 27 | Sat 22 Jan 2022 | 113-2 v GillinghamWigan Athletic 3-2 Gillingham | Sky Bet League One |
| 28 | Sat 29 Jan 2022 | 110-0 v Cheltenham TownCheltenham Town 0-0 Wigan Athletic | Sky Bet League One |
| 29 | Tue 1 Feb 2022 | 111-1 v Oxford UnitedWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 30 | Sat 5 Feb 2022 | 110-2 v Stoke CityStoke City 2-0 Wigan Athletic | Emirates FA Cup Fourth Round |
| 31 | Tue 8 Feb 2022 | 110-1 v Sheffield WednesdaySheffield Wednesday 1-0 Wigan Athletic | Sky Bet League One |
| 32 | Fri 18 Feb 2022 | 11 1-1 v Rotherham UnitedRotherham United 1-1 Wigan Athletic | Sky Bet League One |
| 33 | Tue 22 Feb 2022 | 113-1 v Wycombe WanderersWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 34 | Sat 26 Feb 2022 | 110-3 v SunderlandWigan Athletic 0-3 Sunderland | Sky Bet League One |
| 35 | Tue 1 Mar 2022 | 112-0 v Fleetwood TownWigan Athletic 2-0 Fleetwood Town | Sky Bet League One |
| 36 | Sat 5 Mar 2022 | 111-0 v AFC WimbledonWigan Athletic 1-0 AFC Wimbledon | Sky Bet League One |
| 37 | Tue 8 Mar 2022 | 111-1 v Sutton UnitedWigan Athletic 1-1 Sutton United | Papa John’s Trophy Semi Final |
| 38 | Sat 12 Mar 2022 | 11 1-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Wigan Athletic | Sky Bet League One |
| 39 | Tue 5 Apr 2022 | 113-0 v Accrington StanleyWigan Athletic 3-0 Accrington Stanley | Sky Bet League One |
| 40 | Sat 9 Apr 2022 | 113-1 v Lincoln CityLincoln City 1-3 Wigan Athletic | Sky Bet League One |
| 41 | Tue 12 Apr 2022 | 110-0 v Burton AlbionBurton Albion 0-0 Wigan Athletic | Sky Bet League One |
| 42 | Sat 23 Apr 2022 | 111-1 v Plymouth ArgyleWigan Athletic 1-1 Plymouth Argyle | Sky Bet League One |
| 43 | Tue 26 Apr 2022 | 112-3 v PortsmouthPortsmouth 3-2 Wigan Athletic | Sky Bet League One |
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