| 1 | Sat 7 Aug 2021 | 7 1-2 v SunderlandSunderland 2-1 Wigan Athletic | Sky Bet League One |
| 2 | Tue 24 Aug 2021 | 70-0 v Bolton WanderersWigan Athletic 0-0 Bolton Wanderers | Carabao Cup Second Round |
| 3 | Sat 28 Aug 2021 | 71-0 v PortsmouthWigan Athletic 1-0 Portsmouth | Sky Bet League One |
| 4 | Sat 11 Sep 2021 | 72-1 v Doncaster RoversWigan Athletic 2-1 Doncaster Rovers | Sky Bet League One |
| 5 | Sat 18 Sep 2021 | 74-1 v Accrington StanleyAccrington Stanley 1-4 Wigan Athletic | Sky Bet League One |
| 6 | Tue 21 Sep 2021 | 7 0-2 v SunderlandWigan Athletic 0-2 Sunderland | Carabao Cup Third Round |
| 7 | Sat 25 Sep 2021 | 72-0 v Cheltenham TownWigan Athletic 2-0 Cheltenham Town | Sky Bet League One |
| 8 | Sat 2 Oct 2021 | 72-0 v GillinghamGillingham 0-2 Wigan Athletic | Sky Bet League One |
| 9 | Tue 5 Oct 2021 | 70-2 v Crewe AlexandraCrewe Alexandra 2-0 Wigan Athletic | Papa John’s Trophy |
| 10 | Sat 23 Oct 2021 | 72-0 v AFC WimbledonAFC Wimbledon 0-2 Wigan Athletic | Sky Bet League One |
| 11 | Tue 26 Oct 2021 | 71-2 v Lincoln CityWigan Athletic 1-2 Lincoln City | Sky Bet League One |
| 12 | Tue 2 Nov 2021 | 73-2 v Fleetwood TownFleetwood Town 2-3 Wigan Athletic | Sky Bet League One |
| 13 | Sat 6 Nov 2021 | 70-0 v Solihull MoorsWigan Athletic 0-0 Solihull Moors | Emirates FA Cup First Round |
| 14 | Wed 10 Nov 2021 | 72-0 v Shrewsbury TownWigan Athletic 2-0 Shrewsbury Town | Papa John’s Trophy |
| 15 | Tue 16 Nov 2021 | 72-1 v Solihull MoorsSolihull Moors 1-2 Wigan Athletic | Emirates FA Cup First Round Replay |
| 16 | Tue 23 Nov 2021 | 72-2 v Cambridge UnitedCambridge United 2-2 Wigan Athletic | Sky Bet League One |
| 17 | Sun 5 Dec 2021 | 7 2-1 v Colchester UnitedColchester United 1-2 Wigan Athletic | Emirates FA Cup Second Round |
| 18 | Wed 8 Dec 2021 | 72-1 v Shrewsbury TownWigan Athletic 2-1 Shrewsbury Town | Sky Bet League One |
| 19 | Sat 11 Dec 2021 | 71-1 v Ipswich TownWigan Athletic 1-1 Ipswich Town | Sky Bet League One |
| 20 | Sat 18 Dec 2021 | 73-2 v Oxford UnitedOxford United 2-3 Wigan Athletic | Sky Bet League One |
| 21 | Tue 4 Jan 2022 | 76-0 v Oldham AthleticOldham Athletic 0-6 Wigan Athletic | Papa John’s Trophy Third Round |
| 22 | Sat 8 Jan 2022 | 73-2 v Blackburn RoversWigan Athletic 3-2 Blackburn Rovers | Emirates FA Cup Third Round |
| 23 | Sat 15 Jan 2022 | 72-1 v Doncaster RoversDoncaster Rovers 1-2 Wigan Athletic | Sky Bet League One |
| 24 | Tue 18 Jan 2022 | 72-1 v MorecambeMorecambe 1-2 Wigan Athletic | Sky Bet League One |
| 25 | Sat 22 Jan 2022 | 73-2 v GillinghamWigan Athletic 3-2 Gillingham | Sky Bet League One |
| 26 | Sat 29 Jan 2022 | 70-0 v Cheltenham TownCheltenham Town 0-0 Wigan Athletic | Sky Bet League One |
| 27 | Tue 1 Feb 2022 | 71-1 v Oxford UnitedWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 28 | Sat 5 Feb 2022 | 7 0-2 v Stoke CityStoke City 2-0 Wigan Athletic | Emirates FA Cup Fourth Round |
| 29 | Sat 12 Feb 2022 | 72-1 v Charlton AthleticWigan Athletic 2-1 Charlton Athletic | Sky Bet League One |
| 30 | Tue 15 Feb 2022 | 72-0 v Crewe AlexandraWigan Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 31 | Tue 22 Feb 2022 | 73-1 v Wycombe WanderersWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 32 | Sat 26 Feb 2022 | 70-3 v SunderlandWigan Athletic 0-3 Sunderland | Sky Bet League One |
| 33 | Sat 5 Mar 2022 | 7 1-0 v AFC WimbledonWigan Athletic 1-0 AFC Wimbledon | Sky Bet League One |
| 34 | Tue 8 Mar 2022 | 71-1 v Sutton UnitedWigan Athletic 1-1 Sutton United | Papa John’s Trophy Semi Final |
| 35 | Sat 12 Mar 2022 | 71-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Wigan Athletic | Sky Bet League One |
| 36 | Tue 15 Mar 2022 | 72-0 v Crewe AlexandraCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 37 | Sat 19 Mar 2022 | 74-1 v MorecambeWigan Athletic 4-1 Morecambe | Sky Bet League One |
| 38 | Sat 2 Apr 2022 | 71-1 v Bolton WanderersWigan Athletic 1-1 Bolton Wanderers | Sky Bet League One |
| 39 | Sat 16 Apr 2022 | 71-2 v Cambridge UnitedWigan Athletic 1-2 Cambridge United | Sky Bet League One |
| 40 | Tue 19 Apr 2022 | 72-2 v Ipswich TownIpswich Town 2-2 Wigan Athletic | Sky Bet League One |
| 41 | Tue 26 Apr 2022 | 72-3 v PortsmouthPortsmouth 3-2 Wigan Athletic | Sky Bet League One |
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