| 1 | 15/8/2021 | 270-4 v FeyenoordWillem II 0-4 Feyenoord | Dutch Eredivisie |
| 2 | 22/8/2021 | 273-0 v VitesseVitesse 0-3 Willem II | Dutch Eredivisie |
| 3 | 28/8/2021 | 271-0 v PEC ZwolleWillem II 1-0 PEC Zwolle | Dutch Eredivisie |
| 4 | 12/9/2021 | 270-0 v NEC NijmegenNEC Nijmegen 0-0 Willem II | Dutch Eredivisie |
| 5 | 18/9/2021 | 272-1 v FC GroningenWillem II 2-1 FC Groningen | Dutch Eredivisie |
| 6 | 21/9/2021 | 272-1 v RKC WaalwijkRKC Waalwijk 1-2 Willem II | Dutch Eredivisie |
| 7 | 25/9/2021 | 272-1 v PSV EindhovenWillem II 2-1 PSV Eindhoven | Dutch Eredivisie |
| 8 | 2/10/2021 | 272-3 v Heracles AlmeloHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 9 | 17/10/2021 | 27 1-1 v FC TwenteFC Twente 1-1 Willem II | Dutch Eredivisie |
| 10 | 31/10/2021 | 271-5 v FC UtrechtFC Utrecht 5-1 Willem II | Dutch Eredivisie |
| 11 | 6/11/2021 | 270-3 v Sparta RotterdamWillem II 0-3 Sparta Rotterdam | Dutch Eredivisie |
| 12 | 21/11/2021 | 271-2 v sc Heerenveensc Heerenveen 2-1 Willem II | Dutch Eredivisie |
| 13 | 27/11/2021 | 270-1 v Go Ahead EaglesWillem II 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 14 | 2/12/2021 | 27 0-5 v AjaxAjax 5-0 Willem II | Dutch Eredivisie |
| 15 | 18/12/2021 | 271-4 v AZ AlkmaarAZ Alkmaar 4-1 Willem II | Dutch Eredivisie |
| 16 | 22/12/2021 | 270-1 v NEC NijmegenWillem II 0-1 NEC Nijmegen | Dutch Eredivisie |
| 17 | 14/1/2022 | 270-2 v PEC ZwollePEC Zwolle 2-0 Willem II | Dutch Eredivisie |
| 18 | 22/1/2022 | 270-1 v FC TwenteWillem II 0-1 FC Twente | Dutch Eredivisie |
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