| 1 | Sat 14 Aug 2021 | 5 0-1 v Leicester CityLeicester City 1-0 Wolverhampton Wanderers | Premier League |
| 2 | Sun 22 Aug 2021 | 50-1 v Tottenham HotspurWolverhampton Wanderers 0-1 Tottenham Hotspur | Premier League |
| 3 | Sun 29 Aug 2021 | 50-1 v Manchester UnitedWolverhampton Wanderers 0-1 Manchester United | Premier League |
| 4 | Sat 11 Sep 2021 | 5 2-0 v WatfordWatford 0-2 Wolverhampton Wanderers | Premier League |
| 5 | Sat 18 Sep 2021 | 50-2 v BrentfordWolverhampton Wanderers 0-2 Brentford | Premier League |
| 6 | Sun 26 Sep 2021 | 51-0 v SouthamptonSouthampton 0-1 Wolverhampton Wanderers | Premier League |
| 7 | Sat 2 Oct 2021 | 52-1 v Newcastle UnitedWolverhampton Wanderers 2-1 Newcastle United | Premier League |
| 8 | Sat 16 Oct 2021 | 53-2 v Aston VillaAston Villa 2-3 Wolverhampton Wanderers | Premier League |
| 9 | Sun 19 Dec 2021 | 50-0 v ChelseaWolverhampton Wanderers 0-0 Chelsea | Premier League |
| 10 | Mon 3 Jan 2022 | 51-0 v Manchester UnitedManchester United 0-1 Wolverhampton Wanderers | Premier League |
| 11 | Sun 9 Jan 2022 | 53-0 v Sheffield UnitedWolverhampton Wanderers 3-0 Sheffield United | Emirates FA Cup Third Round |
| 12 | Thu 10 Feb 2022 | 50-1 v ArsenalWolverhampton Wanderers 0-1 Arsenal | Premier League |
| 13 | Sun 20 Feb 2022 | 52-1 v Leicester CityWolverhampton Wanderers 2-1 Leicester City | Premier League |
| 14 | Sun 27 Feb 2022 | 50-1 v West Ham UnitedWest Ham United 1-0 Wolverhampton Wanderers | Premier League |
| 15 | Sat 5 Mar 2022 | 50-2 v Crystal PalaceWolverhampton Wanderers 0-2 Crystal Palace | Premier League |
| 16 | Sun 13 Mar 2022 | 51-0 v EvertonEverton 0-1 Wolverhampton Wanderers | Premier League |
| 17 | Sat 2 Apr 2022 | 5 2-1 v Aston VillaWolverhampton Wanderers 2-1 Aston Villa | Premier League |
| 18 | Fri 8 Apr 2022 | 50-1 v Newcastle UnitedNewcastle United 1-0 Wolverhampton Wanderers | Premier League |
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