| 1 | Sat 14 Aug 2021 | 10-1 v Leicester CityLeicester City 1-0 Wolverhampton Wanderers | Premier League |
| 2 | Sun 22 Aug 2021 | 10-1 v Tottenham HotspurWolverhampton Wanderers 0-1 Tottenham Hotspur | Premier League |
| 3 | Sun 29 Aug 2021 | 10-1 v Manchester UnitedWolverhampton Wanderers 0-1 Manchester United | Premier League |
| 4 | Sat 11 Sep 2021 | 12-0 v WatfordWatford 0-2 Wolverhampton Wanderers | Premier League |
| 5 | Sat 18 Sep 2021 | 1 0-2 v BrentfordWolverhampton Wanderers 0-2 Brentford | Premier League |
| 6 | Sun 26 Sep 2021 | 11-0 v SouthamptonSouthampton 0-1 Wolverhampton Wanderers | Premier League |
| 7 | Sat 2 Oct 2021 | 12-1 v Newcastle UnitedWolverhampton Wanderers 2-1 Newcastle United | Premier League |
| 8 | Sat 16 Oct 2021 | 13-2 v Aston VillaAston Villa 2-3 Wolverhampton Wanderers | Premier League |
| 9 | Sat 23 Oct 2021 | 11-1 v Leeds UnitedLeeds United 1-1 Wolverhampton Wanderers | Premier League |
| 10 | Mon 1 Nov 2021 | 12-1 v EvertonWolverhampton Wanderers 2-1 Everton | Premier League |
| 11 | Sat 6 Nov 2021 | 10-2 v Crystal PalaceCrystal Palace 2-0 Wolverhampton Wanderers | Premier League |
| 12 | Sat 20 Nov 2021 | 11-0 v West Ham UnitedWolverhampton Wanderers 1-0 West Ham United | Premier League |
| 13 | Sat 27 Nov 2021 | 10-0 v Norwich CityNorwich City 0-0 Wolverhampton Wanderers | Premier League |
| 14 | Wed 1 Dec 2021 | 10-0 v BurnleyWolverhampton Wanderers 0-0 Burnley | Premier League |
| 15 | Sat 4 Dec 2021 | 10-1 v LiverpoolWolverhampton Wanderers 0-1 Liverpool | Premier League |
| 16 | Sat 11 Dec 2021 | 10-1 v Manchester CityManchester City 1-0 Wolverhampton Wanderers | Premier League |
| 17 | Wed 15 Dec 2021 | 11-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-1 Wolverhampton Wanderers | Premier League |
| 18 | Sun 19 Dec 2021 | 10-0 v ChelseaWolverhampton Wanderers 0-0 Chelsea | Premier League |
| 19 | Mon 3 Jan 2022 | 1 1-0 v Manchester UnitedManchester United 0-1 Wolverhampton Wanderers | Premier League |
| 20 | Sat 15 Jan 2022 | 13-1 v SouthamptonWolverhampton Wanderers 3-1 Southampton | Premier League |
| 21 | Sat 22 Jan 2022 | 1 2-1 v BrentfordBrentford 1-2 Wolverhampton Wanderers | Premier League |
| 22 | Thu 10 Feb 2022 | 10-1 v ArsenalWolverhampton Wanderers 0-1 Arsenal | Premier League |
| 23 | Sun 13 Feb 2022 | 12-0 v Tottenham HotspurTottenham Hotspur 0-2 Wolverhampton Wanderers | Premier League |
| 24 | Sun 20 Feb 2022 | 12-1 v Leicester CityWolverhampton Wanderers 2-1 Leicester City | Premier League |
| 25 | Thu 24 Feb 2022 | 11-2 v ArsenalArsenal 2-1 Wolverhampton Wanderers | Premier League |
| 26 | Sun 27 Feb 2022 | 10-1 v West Ham UnitedWest Ham United 1-0 Wolverhampton Wanderers | Premier League |
| 27 | Sat 5 Mar 2022 | 10-2 v Crystal PalaceWolverhampton Wanderers 0-2 Crystal Palace | Premier League |
| 28 | Thu 10 Mar 2022 | 14-0 v WatfordWolverhampton Wanderers 4-0 Watford | Premier League |
| 29 | Sun 13 Mar 2022 | 11-0 v EvertonEverton 0-1 Wolverhampton Wanderers | Premier League |
| 30 | Fri 18 Mar 2022 | 12-3 v Leeds UnitedWolverhampton Wanderers 2-3 Leeds United | Premier League |
| 31 | Sat 2 Apr 2022 | 12-1 v Aston VillaWolverhampton Wanderers 2-1 Aston Villa | Premier League |
| 32 | Fri 8 Apr 2022 | 10-1 v Newcastle UnitedNewcastle United 1-0 Wolverhampton Wanderers | Premier League |
| 33 | Sun 24 Apr 2022 | 10-1 v BurnleyBurnley 1-0 Wolverhampton Wanderers | Premier League |
| 34 | Sat 30 Apr 2022 | 10-3 v Brighton & Hove AlbionWolverhampton Wanderers 0-3 Brighton & Hove Albion | Premier League |
| 35 | Sat 7 May 2022 | 12-2 v ChelseaChelsea 2-2 Wolverhampton Wanderers | Premier League |
| 36 | Wed 11 May 2022 | 11-5 v Manchester CityWolverhampton Wanderers 1-5 Manchester City | Premier League |
| 37 | Sun 22 May 2022 | 11-3 v LiverpoolLiverpool 3-1 Wolverhampton Wanderers | Premier League |
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