| 1 | Sun 6 Sep 2020 | 31-1 v BrentfordBrentford 1-1 Wycombe Wanderers | Carabao Cup First Round |
| 2 | Sat 12 Sep 2020 | 30-1 v Rotherham UnitedWycombe Wanderers 0-1 Rotherham United | Sky Bet Championship |
| 3 | Sat 19 Sep 2020 | 30-5 v Blackburn RoversBlackburn Rovers 5-0 Wycombe Wanderers | Sky Bet Championship |
| 4 | Sat 3 Oct 2020 | 30-2 v Luton TownLuton Town 2-0 Wycombe Wanderers | Sky Bet Championship |
| 5 | Sat 17 Oct 2020 | 31-2 v MillwallWycombe Wanderers 1-2 Millwall | Sky Bet Championship |
| 6 | Tue 20 Oct 2020 | 30-1 v ReadingReading 1-0 Wycombe Wanderers | Sky Bet Championship |
| 7 | Sat 24 Oct 2020 | 31-2 v Norwich CityNorwich City 2-1 Wycombe Wanderers | Sky Bet Championship |
| 8 | Tue 27 Oct 2020 | 31-1 v WatfordWycombe Wanderers 1-1 Watford | Sky Bet Championship |
| 9 | Sat 31 Oct 2020 | 3 1-0 v Sheffield WednesdayWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet Championship |
| 10 | Wed 4 Nov 2020 | 32-1 v Birmingham CityBirmingham City 1-2 Wycombe Wanderers | Sky Bet Championship |
| 11 | Sat 7 Nov 2020 | 30-2 v Nottingham ForestNottingham Forest 2-0 Wycombe Wanderers | Sky Bet Championship |
| 12 | Sat 21 Nov 2020 | 30-0 v BrentfordWycombe Wanderers 0-0 Brentford | Sky Bet Championship |
| 13 | Tue 24 Nov 2020 | 30-0 v Huddersfield TownWycombe Wanderers 0-0 Huddersfield Town | Sky Bet Championship |
| 14 | Sat 28 Nov 2020 | 31-1 v Derby CountyDerby County 1-1 Wycombe Wanderers | Sky Bet Championship |
| 15 | Wed 2 Dec 2020 | 3 0-1 v Stoke CityWycombe Wanderers 0-1 Stoke City | Sky Bet Championship |
| 16 | Sat 5 Dec 2020 | 32-2 v Preston North EndPreston North End 2-2 Wycombe Wanderers | Sky Bet Championship |
| 17 | Wed 9 Dec 2020 | 3 1-2 v BarnsleyBarnsley 2-1 Wycombe Wanderers | Sky Bet Championship |
| 18 | Sat 12 Dec 2020 | 31-2 v Coventry CityWycombe Wanderers 1-2 Coventry City | Sky Bet Championship |
| 19 | Tue 15 Dec 2020 | 30-1 v AFC BournemouthAFC Bournemouth 1-0 Wycombe Wanderers | Sky Bet Championship |
| 20 | Sat 19 Dec 2020 | 3 1-1 v Queens Park RangersWycombe Wanderers 1-1 Queens Park Rangers | Sky Bet Championship |
| 21 | Sat 26 Dec 2020 | 3 1-2 v Bristol CityBristol City 2-1 Wycombe Wanderers | Sky Bet Championship |
| 22 | Tue 29 Dec 2020 | 32-1 v Cardiff CityWycombe Wanderers 2-1 Cardiff City | Sky Bet Championship |
| 23 | Sat 2 Jan 2021 | 31-3 v MiddlesbroughWycombe Wanderers 1-3 Middlesbrough | Sky Bet Championship |
| 24 | Sat 9 Jan 2021 | 34-1 v Preston North EndWycombe Wanderers 4-1 Preston North End | Emirates FA Cup Third Round |
| 25 | Mon 25 Jan 2021 | 31-4 v Tottenham HotspurWycombe Wanderers 1-4 Tottenham Hotspur | Emirates FA Cup Fourth Round |
| 26 | Sat 13 Feb 2021 | 33-2 v Huddersfield TownHuddersfield Town 2-3 Wycombe Wanderers | Sky Bet Championship |
| 27 | Sun 28 Feb 2021 | 30-2 v Norwich CityWycombe Wanderers 0-2 Norwich City | Sky Bet Championship |
| 28 | Wed 3 Mar 2021 | 30-2 v WatfordWatford 2-0 Wycombe Wanderers | Sky Bet Championship |
| 29 | Sat 6 Mar 2021 | 30-2 v Stoke CityStoke City 2-0 Wycombe Wanderers | Sky Bet Championship |
| 30 | Tue 9 Mar 2021 | 30-1 v Queens Park RangersQueens Park Rangers 1-0 Wycombe Wanderers | Sky Bet Championship |
| 31 | Sat 13 Mar 2021 | 31-0 v Preston North EndWycombe Wanderers 1-0 Preston North End | Sky Bet Championship |
| 32 | Wed 17 Mar 2021 | 3 1-3 v BarnsleyWycombe Wanderers 1-3 Barnsley | Sky Bet Championship |
| 33 | Sat 20 Mar 2021 | 30-0 v Coventry CityCoventry City 0-0 Wycombe Wanderers | Sky Bet Championship |
| 34 | Fri 2 Apr 2021 | 31-0 v Blackburn RoversWycombe Wanderers 1-0 Blackburn Rovers | Sky Bet Championship |
| 35 | Mon 5 Apr 2021 | 33-0 v Rotherham UnitedRotherham United 0-3 Wycombe Wanderers | Sky Bet Championship |
| 36 | Sat 17 Apr 2021 | 32-2 v Swansea CitySwansea City 2-2 Wycombe Wanderers | Sky Bet Championship |
| 37 | Wed 21 Apr 2021 | 32-1 v Bristol CityWycombe Wanderers 2-1 Bristol City | Sky Bet Championship |
| 38 | Sat 24 Apr 2021 | 31-2 v Cardiff CityCardiff City 2-1 Wycombe Wanderers | Sky Bet Championship |
| 39 | Sat 1 May 2021 | 3 1-0 v AFC BournemouthWycombe Wanderers 1-0 AFC Bournemouth | Sky Bet Championship |
| 40 | Sat 8 May 2021 | 33-0 v MiddlesbroughMiddlesbrough 0-3 Wycombe Wanderers | Sky Bet Championship |
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