| 1 | Sat 6 Nov 2021 | 382-2 v Hartlepool UnitedHartlepool United 2-2 Wycombe Wanderers | Emirates FA Cup First Round |
| 2 | Tue 9 Nov 2021 | 380-5 v Burton AlbionWycombe Wanderers 0-5 Burton Albion | Papa John’s Trophy |
| 3 | Tue 7 Dec 2021 | 38 2-1 v Burton AlbionWycombe Wanderers 2-1 Burton Albion | Sky Bet League One |
| 4 | Wed 29 Dec 2021 | 380-1 v Ipswich TownIpswich Town 1-0 Wycombe Wanderers | Sky Bet League One |
| 5 | Sat 1 Jan 2022 | 381-0 v Charlton AthleticCharlton Athletic 0-1 Wycombe Wanderers | Sky Bet League One |
| 6 | Sat 8 Jan 2022 | 383-3 v SunderlandWycombe Wanderers 3-3 Sunderland | Sky Bet League One |
| 7 | Tue 8 Feb 2022 | 380-0 v Shrewsbury TownWycombe Wanderers 0-0 Shrewsbury Town | Sky Bet League One |
| 8 | Sat 12 Feb 2022 | 381-1 v Lincoln CityLincoln City 1-1 Wycombe Wanderers | Sky Bet League One |
| 9 | Sat 19 Feb 2022 | 385-5 v Cheltenham TownWycombe Wanderers 5-5 Cheltenham Town | Sky Bet League One |
| 10 | Sat 26 Feb 2022 | 382-3 v Accrington StanleyAccrington Stanley 3-2 Wycombe Wanderers | Sky Bet League One |
| 11 | Sat 5 Mar 2022 | 383-1 v Crewe AlexandraCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 12 | Tue 5 Apr 2022 | 384-1 v Cambridge UnitedCambridge United 1-4 Wycombe Wanderers | Sky Bet League One |
| 13 | Sat 9 Apr 2022 | 381-1 v GillinghamGillingham 1-1 Wycombe Wanderers | Sky Bet League One |
| 14 | Fri 15 Apr 2022 | 382-0 v Plymouth ArgyleWycombe Wanderers 2-0 Plymouth Argyle | Sky Bet League One |
| 15 | Mon 18 Apr 2022 | 381-1 v AFC WimbledonAFC Wimbledon 1-1 Wycombe Wanderers | Sky Bet League One |
| 16 | Sat 23 Apr 2022 | 381-0 v Sheffield WednesdayWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
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