| 1 | Sat 28 Aug 2021 | 71-3 v SunderlandSunderland 3-1 Wycombe Wanderers | Sky Bet League One |
| 2 | Sat 11 Sep 2021 | 70-0 v Oxford UnitedOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 3 | Tue 21 Sep 2021 | 71-6 v Manchester CityManchester City 6-1 Wycombe Wanderers | Carabao Cup Third Round |
| 4 | Sat 25 Sep 2021 | 70-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One |
| 5 | Tue 28 Sep 2021 | 72-1 v Shrewsbury TownShrewsbury Town 1-2 Wycombe Wanderers | Sky Bet League One |
| 6 | Sat 2 Oct 2021 | 74-3 v MorecambeWycombe Wanderers 4-3 Morecambe | Sky Bet League One |
| 7 | Tue 5 Oct 2021 | 7 1-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Wycombe Wanderers | Papa John’s Trophy |
| 8 | Sat 9 Oct 2021 | 72-0 v GillinghamWycombe Wanderers 2-0 Gillingham | Sky Bet League One |
| 9 | Sat 16 Oct 2021 | 72-0 v Doncaster RoversDoncaster Rovers 0-2 Wycombe Wanderers | Sky Bet League One |
| 10 | Sat 30 Oct 2021 | 73-3 v Fleetwood TownFleetwood Town 3-3 Wycombe Wanderers | Sky Bet League One |
| 11 | Tue 2 Nov 2021 | 71-4 v Ipswich TownWycombe Wanderers 1-4 Ipswich Town | Sky Bet League One |
| 12 | Sat 6 Nov 2021 | 72-2 v Hartlepool UnitedHartlepool United 2-2 Wycombe Wanderers | Emirates FA Cup First Round |
| 13 | Sat 13 Nov 2021 | 70-1 v PortsmouthWycombe Wanderers 0-1 Portsmouth | Sky Bet League One |
| 14 | Tue 16 Nov 2021 | 7 0-1 v Hartlepool UnitedWycombe Wanderers 0-1 Hartlepool United | Emirates FA Cup First Round Replay |
| 15 | Sat 20 Nov 2021 | 7 1-0 v Bolton WanderersWycombe Wanderers 1-0 Bolton Wanderers | Sky Bet League One |
| 16 | Tue 23 Nov 2021 | 7 3-0 v Plymouth ArgylePlymouth Argyle 0-3 Wycombe Wanderers | Sky Bet League One |
| 17 | Sat 27 Nov 2021 | 72-2 v Sheffield WednesdaySheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
| 18 | Tue 7 Dec 2021 | 72-1 v Burton AlbionWycombe Wanderers 2-1 Burton Albion | Sky Bet League One |
| 19 | Wed 29 Dec 2021 | 70-1 v Ipswich TownIpswich Town 1-0 Wycombe Wanderers | Sky Bet League One |
| 20 | Sat 1 Jan 2022 | 7 1-0 v Charlton AthleticCharlton Athletic 0-1 Wycombe Wanderers | Sky Bet League One |
| 21 | Sat 15 Jan 2022 | 72-0 v Oxford UnitedWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 22 | Sat 22 Jan 2022 | 72-3 v MorecambeMorecambe 3-2 Wycombe Wanderers | Sky Bet League One |
| 23 | Sat 29 Jan 2022 | 70-1 v Milton Keynes DonsWycombe Wanderers 0-1 Milton Keynes Dons | Sky Bet League One |
| 24 | Sat 12 Feb 2022 | 71-1 v Lincoln CityLincoln City 1-1 Wycombe Wanderers | Sky Bet League One |
| 25 | Sat 19 Feb 2022 | 7 5-5 v Cheltenham TownWycombe Wanderers 5-5 Cheltenham Town | Sky Bet League One |
| 26 | Tue 22 Feb 2022 | 71-3 v Wigan AthleticWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 27 | Tue 1 Mar 2022 | 73-0 v Cambridge UnitedWycombe Wanderers 3-0 Cambridge United | Sky Bet League One |
| 28 | Sat 5 Mar 2022 | 73-1 v Crewe AlexandraCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 29 | Sat 2 Apr 2022 | 72-0 v Doncaster RoversWycombe Wanderers 2-0 Doncaster Rovers | Sky Bet League One |
| 30 | Tue 5 Apr 2022 | 74-1 v Cambridge UnitedCambridge United 1-4 Wycombe Wanderers | Sky Bet League One |
| 31 | Sat 9 Apr 2022 | 71-1 v GillinghamGillingham 1-1 Wycombe Wanderers | Sky Bet League One |
| 32 | Fri 15 Apr 2022 | 72-0 v Plymouth ArgyleWycombe Wanderers 2-0 Plymouth Argyle | Sky Bet League One |
| 33 | Sat 23 Apr 2022 | 71-0 v Sheffield WednesdayWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
| 34 | Sat 30 Apr 2022 | 72-1 v Burton AlbionBurton Albion 1-2 Wycombe Wanderers | Sky Bet League One |
| 35 | Sun 8 May 2022 | 70-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One Play-off Semi Final |
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