| 1 | Sat 7 Aug 2021 | 22-1 v Accrington StanleyWycombe Wanderers 2-1 Accrington Stanley | Sky Bet League One |
| 2 | Tue 10 Aug 2021 | 20-0 v Exeter CityExeter City 0-0 Wycombe Wanderers | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 23-1 v Cheltenham TownCheltenham Town 1-3 Wycombe Wanderers | Sky Bet League One |
| 4 | Tue 17 Aug 2021 | 21-1 v Wigan AthleticWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 5 | Sat 21 Aug 2021 | 2 1-0 v Lincoln CityWycombe Wanderers 1-0 Lincoln City | Sky Bet League One |
| 6 | Sat 28 Aug 2021 | 21-3 v SunderlandSunderland 3-1 Wycombe Wanderers | Sky Bet League One |
| 7 | Sat 11 Sep 2021 | 20-0 v Oxford UnitedOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 8 | Sat 18 Sep 2021 | 22-1 v Charlton AthleticWycombe Wanderers 2-1 Charlton Athletic | Sky Bet League One |
| 9 | Sat 25 Sep 2021 | 20-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One |
| 10 | Tue 28 Sep 2021 | 2 2-1 v Shrewsbury TownShrewsbury Town 1-2 Wycombe Wanderers | Sky Bet League One |
| 11 | Tue 5 Oct 2021 | 21-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Wycombe Wanderers | Papa John’s Trophy |
| 12 | Sat 30 Oct 2021 | 23-3 v Fleetwood TownFleetwood Town 3-3 Wycombe Wanderers | Sky Bet League One |
| 13 | Tue 16 Nov 2021 | 20-1 v Hartlepool UnitedWycombe Wanderers 0-1 Hartlepool United | Emirates FA Cup First Round Replay |
| 14 | Tue 7 Dec 2021 | 22-1 v Burton AlbionWycombe Wanderers 2-1 Burton Albion | Sky Bet League One |
| 15 | Sat 11 Dec 2021 | 22-2 v AFC WimbledonWycombe Wanderers 2-2 AFC Wimbledon | Sky Bet League One |
| 16 | Sat 1 Jan 2022 | 21-0 v Charlton AthleticCharlton Athletic 0-1 Wycombe Wanderers | Sky Bet League One |
| 17 | Sat 8 Jan 2022 | 23-3 v SunderlandWycombe Wanderers 3-3 Sunderland | Sky Bet League One |
| 18 | Tue 11 Jan 2022 | 22-0 v Bolton WanderersBolton Wanderers 0-2 Wycombe Wanderers | Sky Bet League One |
| 19 | Sat 15 Jan 2022 | 22-0 v Oxford UnitedWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 20 | Sat 22 Jan 2022 | 22-3 v MorecambeMorecambe 3-2 Wycombe Wanderers | Sky Bet League One |
| 21 | Sat 29 Jan 2022 | 20-1 v Milton Keynes DonsWycombe Wanderers 0-1 Milton Keynes Dons | Sky Bet League One |
| 22 | Tue 8 Feb 2022 | 20-0 v Shrewsbury TownWycombe Wanderers 0-0 Shrewsbury Town | Sky Bet League One |
| 23 | Sat 12 Feb 2022 | 21-1 v Lincoln CityLincoln City 1-1 Wycombe Wanderers | Sky Bet League One |
| 24 | Sat 19 Feb 2022 | 2 5-5 v Cheltenham TownWycombe Wanderers 5-5 Cheltenham Town | Sky Bet League One |
| 25 | Tue 22 Feb 2022 | 21-3 v Wigan AthleticWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 26 | Sat 26 Feb 2022 | 22-3 v Accrington StanleyAccrington Stanley 3-2 Wycombe Wanderers | Sky Bet League One |
| 27 | Tue 1 Mar 2022 | 23-0 v Cambridge UnitedWycombe Wanderers 3-0 Cambridge United | Sky Bet League One |
| 28 | Fri 15 Apr 2022 | 22-0 v Plymouth ArgyleWycombe Wanderers 2-0 Plymouth Argyle | Sky Bet League One |
| 29 | Sat 23 Apr 2022 | 21-0 v Sheffield WednesdayWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
| 30 | Sun 8 May 2022 | 20-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One Play-off Semi Final |
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