| 1 | Sat 7 Aug 2021 | 282-1 v Accrington StanleyWycombe Wanderers 2-1 Accrington Stanley | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 283-1 v Cheltenham TownCheltenham Town 1-3 Wycombe Wanderers | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 281-1 v Wigan AthleticWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 281-0 v Lincoln CityWycombe Wanderers 1-0 Lincoln City | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 28 1-3 v SunderlandSunderland 3-1 Wycombe Wanderers | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 280-0 v Oxford UnitedOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 282-1 v Charlton AthleticWycombe Wanderers 2-1 Charlton Athletic | Sky Bet League One |
| 8 | Tue 21 Sep 2021 | 281-6 v Manchester CityManchester City 6-1 Wycombe Wanderers | Carabao Cup Third Round |
| 9 | Sat 25 Sep 2021 | 280-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One |
| 10 | Tue 28 Sep 2021 | 282-1 v Shrewsbury TownShrewsbury Town 1-2 Wycombe Wanderers | Sky Bet League One |
| 11 | Sat 2 Oct 2021 | 284-3 v MorecambeWycombe Wanderers 4-3 Morecambe | Sky Bet League One |
| 12 | Sat 9 Oct 2021 | 282-0 v GillinghamWycombe Wanderers 2-0 Gillingham | Sky Bet League One |
| 13 | Sat 16 Oct 2021 | 282-0 v Doncaster RoversDoncaster Rovers 0-2 Wycombe Wanderers | Sky Bet League One |
| 14 | Tue 19 Oct 2021 | 280-0 v Rotherham UnitedRotherham United 0-0 Wycombe Wanderers | Sky Bet League One |
| 15 | Sat 23 Oct 2021 | 282-1 v Crewe AlexandraWycombe Wanderers 2-1 Crewe Alexandra | Sky Bet League One |
| 16 | Sat 30 Oct 2021 | 28 3-3 v Fleetwood TownFleetwood Town 3-3 Wycombe Wanderers | Sky Bet League One |
| 17 | Tue 2 Nov 2021 | 28 1-4 v Ipswich TownWycombe Wanderers 1-4 Ipswich Town | Sky Bet League One |
| 18 | Sat 6 Nov 2021 | 282-2 v Hartlepool UnitedHartlepool United 2-2 Wycombe Wanderers | Emirates FA Cup First Round |
| 19 | Sat 13 Nov 2021 | 280-1 v PortsmouthWycombe Wanderers 0-1 Portsmouth | Sky Bet League One |
| 20 | Tue 16 Nov 2021 | 280-1 v Hartlepool UnitedWycombe Wanderers 0-1 Hartlepool United | Emirates FA Cup First Round Replay |
| 21 | Wed 29 Dec 2021 | 28 0-1 v Ipswich TownIpswich Town 1-0 Wycombe Wanderers | Sky Bet League One |
| 22 | Sat 1 Jan 2022 | 281-0 v Charlton AthleticCharlton Athletic 0-1 Wycombe Wanderers | Sky Bet League One |
| 23 | Sat 8 Jan 2022 | 28 3-3 v SunderlandWycombe Wanderers 3-3 Sunderland | Sky Bet League One |
| 24 | Tue 11 Jan 2022 | 28 2-0 v Bolton WanderersBolton Wanderers 0-2 Wycombe Wanderers | Sky Bet League One |
| 25 | Sat 15 Jan 2022 | 282-0 v Oxford UnitedWycombe Wanderers 2-0 Oxford United | Sky Bet League One |
| 26 | Sat 12 Feb 2022 | 28 1-1 v Lincoln CityLincoln City 1-1 Wycombe Wanderers | Sky Bet League One |
| 27 | Tue 22 Feb 2022 | 281-3 v Wigan AthleticWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 28 | Sat 26 Feb 2022 | 282-3 v Accrington StanleyAccrington Stanley 3-2 Wycombe Wanderers | Sky Bet League One |
| 29 | Tue 1 Mar 2022 | 283-0 v Cambridge UnitedWycombe Wanderers 3-0 Cambridge United | Sky Bet League One |
| 30 | Sat 5 Mar 2022 | 283-1 v Crewe AlexandraCrewe Alexandra 1-3 Wycombe Wanderers | Sky Bet League One |
| 31 | Sat 12 Mar 2022 | 280-0 v Rotherham UnitedWycombe Wanderers 0-0 Rotherham United | Sky Bet League One |
| 32 | Tue 15 Mar 2022 | 28 1-0 v Fleetwood TownWycombe Wanderers 1-0 Fleetwood Town | Sky Bet League One |
| 33 | Sat 19 Mar 2022 | 280-0 v PortsmouthPortsmouth 0-0 Wycombe Wanderers | Sky Bet League One |
| 34 | Sat 2 Apr 2022 | 282-0 v Doncaster RoversWycombe Wanderers 2-0 Doncaster Rovers | Sky Bet League One |
| 35 | Tue 5 Apr 2022 | 284-1 v Cambridge UnitedCambridge United 1-4 Wycombe Wanderers | Sky Bet League One |
| 36 | Sat 9 Apr 2022 | 28 1-1 v GillinghamGillingham 1-1 Wycombe Wanderers | Sky Bet League One |
| 37 | Fri 15 Apr 2022 | 28 2-0 v Plymouth ArgyleWycombe Wanderers 2-0 Plymouth Argyle | Sky Bet League One |
| 38 | Mon 18 Apr 2022 | 28 1-1 v AFC WimbledonAFC Wimbledon 1-1 Wycombe Wanderers | Sky Bet League One |
| 39 | Sat 23 Apr 2022 | 281-0 v Sheffield WednesdayWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
| 40 | Sat 30 Apr 2022 | 282-1 v Burton AlbionBurton Albion 1-2 Wycombe Wanderers | Sky Bet League One |
| 41 | Thu 5 May 2022 | 282-0 v Milton Keynes DonsWycombe Wanderers 2-0 Milton Keynes Dons | Sky Bet League One Play-off Semi Final |
| 42 | Sun 8 May 2022 | 28 0-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One Play-off Semi Final |
| 43 | Sat 21 May 2022 | 280-2 v SunderlandSunderland 2-0 Wycombe Wanderers | Sky Bet League One Play-off Final |
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