| 1 | Sun 15 Aug 2021 | 4 3-1 v Hertha Berlin1. FC Köln 3-1 Hertha Berlin | German Bundesliga |
| 2 | Sat 30 Oct 2021 | 4 0-2 v Borussia DortmundBorussia Dortmund 2-0 1. FC Köln | German Bundesliga |
| 3 | Sun 7 Nov 2021 | 42-2 v 1. FC Union Berlin1. FC Köln 2-2 1. FC Union Berlin | German Bundesliga |
| 4 | Tue 14 Dec 2021 | 43-2 v VfL WolfsburgVfL Wolfsburg 2-3 1. FC Köln | German Bundesliga |
| 5 | Sun 19 Dec 2021 | 41-0 v VfB Stuttgart1. FC Köln 1-0 VfB Stuttgart | German Bundesliga |
| 6 | Sun 9 Jan 2022 | 4 3-1 v Hertha BerlinHertha Berlin 1-3 1. FC Köln | German Bundesliga |
| 7 | Sat 15 Jan 2022 | 40-4 v Bayern Munich1. FC Köln 0-4 Bayern Munich | German Bundesliga |
| 8 | Sat 22 Jan 2022 | 42-2 v VfL BochumVfL Bochum 2-2 1. FC Köln | German Bundesliga |
| 9 | Sat 5 Feb 2022 | 41-0 v SC Freiburg1. FC Köln 1-0 SC Freiburg | German Bundesliga |
| 10 | Fri 11 Feb 2022 | 4 1-3 v RB LeipzigRB Leipzig 3-1 1. FC Köln | German Bundesliga |
| 11 | Sat 19 Feb 2022 | 41-0 v Eintracht Frankfurt1. FC Köln 1-0 Eintracht Frankfurt | German Bundesliga |
| 12 | Sat 26 Feb 2022 | 41-1 v Greuther FürthGreuther Fürth 1-1 1. FC Köln | German Bundesliga |
| 13 | Sun 13 Mar 2022 | 41-0 v Bayer 04 LeverkusenBayer 04 Leverkusen 0-1 1. FC Köln | German Bundesliga |
| 14 | Sun 20 Mar 2022 | 41-1 v Borussia Dortmund1. FC Köln 1-1 Borussia Dortmund | German Bundesliga |
| 15 | Fri 1 Apr 2022 | 4 0-1 v 1. FC Union Berlin1. FC Union Berlin 1-0 1. FC Köln | German Bundesliga |
| 16 | Sat 16 Apr 2022 | 4 3-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-3 1. FC Köln | German Bundesliga |
| 17 | Sat 23 Apr 2022 | 43-1 v Arminia Bielefeld1. FC Köln 3-1 Arminia Bielefeld | German Bundesliga |
| 18 | Sat 30 Apr 2022 | 4 4-1 v FC AugsburgFC Augsburg 1-4 1. FC Köln | German Bundesliga |
| 19 | Sat 7 May 2022 | 40-1 v VfL Wolfsburg1. FC Köln 0-1 VfL Wolfsburg | German Bundesliga |
| 20 | Sat 14 May 2022 | 41-2 v VfB StuttgartVfB Stuttgart 2-1 1. FC Köln | German Bundesliga |
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