| 1 | Sat 19 Sep 2020 | 203-2 v 1. FC Köln1. FC Köln 2-3 1899 Hoffenheim | German Bundesliga |
| 2 | Sun 27 Sep 2020 | 204-1 v Bayern Munich1899 Hoffenheim 4-1 Bayern Munich | German Bundesliga |
| 3 | Sat 3 Oct 2020 | 201-2 v Eintracht FrankfurtEintracht Frankfurt 2-1 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 17 Oct 2020 | 200-1 v Borussia Dortmund1899 Hoffenheim 0-1 Borussia Dortmund | German Bundesliga |
| 5 | Thu 22 Oct 2020 | 202-0 v Red Star Belgrade1899 Hoffenheim 2-0 Red Star Belgrade | Europa League Group L |
| 6 | Sun 25 Oct 2020 | 20 1-1 v Werder BremenWerder Bremen 1-1 1899 Hoffenheim | German Bundesliga |
| 7 | Thu 29 Oct 2020 | 204-1 v KAA GentKAA Gent 1-4 1899 Hoffenheim | Europa League Group L |
| 8 | Mon 2 Nov 2020 | 201-3 v 1. FC Union Berlin1899 Hoffenheim 1-3 1. FC Union Berlin | German Bundesliga |
| 9 | Thu 5 Nov 2020 | 205-0 v Slovan Liberec1899 Hoffenheim 5-0 Slovan Liberec | Europa League Group L |
| 10 | Sun 8 Nov 2020 | 201-2 v VfL WolfsburgVfL Wolfsburg 2-1 1899 Hoffenheim | German Bundesliga |
| 11 | Sat 21 Nov 2020 | 203-3 v VfB Stuttgart1899 Hoffenheim 3-3 VfB Stuttgart | German Bundesliga |
| 12 | Thu 26 Nov 2020 | 20 2-0 v Slovan LiberecSlovan Liberec 0-2 1899 Hoffenheim | Europa League Group L |
| 13 | Sun 29 Nov 2020 | 201-1 v Mainz 05Mainz 05 1-1 1899 Hoffenheim | German Bundesliga |
| 14 | Thu 3 Dec 2020 | 200-0 v Red Star BelgradeRed Star Belgrade 0-0 1899 Hoffenheim | Europa League Group L |
| 15 | Mon 7 Dec 2020 | 203-1 v FC Augsburg1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
| 16 | Thu 10 Dec 2020 | 204-1 v KAA Gent1899 Hoffenheim 4-1 KAA Gent | Europa League Group L |
| 17 | Sun 13 Dec 2020 | 201-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-1 1899 Hoffenheim | German Bundesliga |
| 18 | Wed 16 Dec 2020 | 200-1 v RB Leipzig1899 Hoffenheim 0-1 RB Leipzig | German Bundesliga |
| 19 | Sat 9 Jan 2021 | 20 0-4 v FC Schalke 04FC Schalke 04 4-0 1899 Hoffenheim | German Bundesliga |
| 20 | Sat 16 Jan 2021 | 200-0 v Arminia Bielefeld1899 Hoffenheim 0-0 Arminia Bielefeld | German Bundesliga |
| 21 | Tue 19 Jan 2021 | 20 3-0 v Hertha BerlinHertha Berlin 0-3 1899 Hoffenheim | German Bundesliga |
| 22 | Sun 24 Jan 2021 | 203-0 v 1. FC Köln1899 Hoffenheim 3-0 1. FC Köln | German Bundesliga |
| 23 | Sat 30 Jan 2021 | 201-4 v Bayern MunichBayern Munich 4-1 1899 Hoffenheim | German Bundesliga |
| 24 | Sun 7 Feb 2021 | 201-3 v Eintracht Frankfurt1899 Hoffenheim 1-3 Eintracht Frankfurt | German Bundesliga |
| 25 | Sat 13 Feb 2021 | 20 2-2 v Borussia DortmundBorussia Dortmund 2-2 1899 Hoffenheim | German Bundesliga |
| 26 | Thu 18 Feb 2021 | 203-3 v MoldeMolde 3-3 1899 Hoffenheim | Europa League Round of 32 |
| 27 | Sat 3 Apr 2021 | 201-2 v FC AugsburgFC Augsburg 2-1 1899 Hoffenheim | German Bundesliga |
| 28 | Fri 16 Apr 2021 | 200-0 v RB LeipzigRB Leipzig 0-0 1899 Hoffenheim | German Bundesliga |
| 29 | Sat 8 May 2021 | 204-2 v FC Schalke 041899 Hoffenheim 4-2 FC Schalke 04 | German Bundesliga |
| 30 | Sat 15 May 2021 | 20 1-1 v Arminia BielefeldArminia Bielefeld 1-1 1899 Hoffenheim | German Bundesliga |
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