| 1 | Sat 19 Aug | 31-2 v SC Freiburg1899 Hoffenheim 1-2 SC Freiburg | German Bundesliga |
| 2 | Sat 26 Aug | 3 3-2 v 1 FC Heidenheim1 FC Heidenheim 2-3 1899 Hoffenheim | German Bundesliga |
| 3 | Sat 16 Sep | 3 3-1 v 1 FC Köln1 FC Köln 1-3 1899 Hoffenheim | German Bundesliga |
| 4 | Sat 23 Sep | 32-0 v 1 FC Union Berlin1 FC Union Berlin 0-2 1899 Hoffenheim | German Bundesliga |
| 5 | Sat 7 Oct | 33-2 v Werder BremenWerder Bremen 2-3 1899 Hoffenheim | German Bundesliga |
| 6 | Sat 21 Oct | 31-3 v Eintracht Frankfurt1899 Hoffenheim 1-3 Eintracht Frankfurt | German Bundesliga |
| 7 | Sat 28 Oct | 33-2 v VfB StuttgartVfB Stuttgart 2-3 1899 Hoffenheim | German Bundesliga |
| 8 | Sun 26 Nov | 31-1 v Mainz 051899 Hoffenheim 1-1 Mainz 05 | German Bundesliga |
| 9 | Sat 2 Dec | 31-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-1 1899 Hoffenheim | German Bundesliga |
| 10 | Fri 8 Dec | 33-1 v VfL Bochum1899 Hoffenheim 3-1 VfL Bochum | German Bundesliga |
| 11 | Sat 16 Dec | 31-3 v RB LeipzigRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 12 | Tue 19 Dec | 33-3 v Darmstadt 981899 Hoffenheim 3-3 Darmstadt 98 | German Bundesliga |
| 13 | Fri 12 Jan | 30-3 v Bayern MunichBayern Munich 3-0 1899 Hoffenheim | German Bundesliga |
| 14 | Sat 20 Jan | 3 2-3 v SC FreiburgSC Freiburg 3-2 1899 Hoffenheim | German Bundesliga |
| 15 | Sat 27 Jan | 31-1 v 1 FC Heidenheim1899 Hoffenheim 1-1 1 FC Heidenheim | German Bundesliga |
| 16 | Sun 4 Feb | 32-2 v VfL WolfsburgVfL Wolfsburg 2-2 1899 Hoffenheim | German Bundesliga |
| 17 | Sun 11 Feb | 31-1 v 1 FC Köln1899 Hoffenheim 1-1 1 FC Köln | German Bundesliga |
| 18 | Sat 17 Feb | 3 0-1 v 1 FC Union Berlin1899 Hoffenheim 0-1 1 FC Union Berlin | German Bundesliga |
| 19 | Sun 25 Feb | 33-2 v Borussia DortmundBorussia Dortmund 2-3 1899 Hoffenheim | German Bundesliga |
| 20 | Sun 3 Mar | 3 2-1 v Werder Bremen1899 Hoffenheim 2-1 Werder Bremen | German Bundesliga |
| 21 | Sat 16 Mar | 3 0-3 v VfB Stuttgart1899 Hoffenheim 0-3 VfB Stuttgart | German Bundesliga |
| 22 | Sat 30 Mar | 31-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-1 1899 Hoffenheim | German Bundesliga |
| 23 | Sun 7 Apr | 3 3-1 v FC Augsburg1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
| 24 | Sat 13 Apr | 31-4 v Mainz 05Mainz 05 4-1 1899 Hoffenheim | German Bundesliga |
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