| 1 | 7/8/2021 | 12-1 v Doncaster RoversDoncaster Rovers 1-2 AFC Wimbledon | Sky Bet League One |
| 2 | 10/8/2021 | 11-0 v Charlton AthleticCharlton Athletic 0-1 AFC Wimbledon | Carabao Cup First Round |
| 3 | 14/8/2021 | 1 3-3 v Bolton WanderersAFC Wimbledon 3-3 Bolton Wanderers | Sky Bet League One |
| 4 | 17/8/2021 | 11-1 v GillinghamAFC Wimbledon 1-1 Gillingham | Sky Bet League One |
| 5 | 21/8/2021 | 10-1 v SunderlandSunderland 1-0 AFC Wimbledon | Sky Bet League One |
| 6 | 24/8/2021 | 11-0 v Northampton TownNorthampton Town 0-1 AFC Wimbledon | Carabao Cup Second Round |
| 7 | 28/8/2021 | 12-2 v Ipswich TownIpswich Town 2-2 AFC Wimbledon | Sky Bet League One |
| 8 | 4/9/2021 | 13-1 v Oxford UnitedAFC Wimbledon 3-1 Oxford United | Sky Bet League One |
| 9 | 7/9/2021 | 15-3 v PortsmouthAFC Wimbledon 5-3 Portsmouth | Checkatrade Trophy |
| 10 | 11/9/2021 | 14-3 v MorecambeMorecambe 3-4 AFC Wimbledon | Sky Bet League One |
| 11 | 18/9/2021 | 10-1 v Plymouth ArgyleAFC Wimbledon 0-1 Plymouth Argyle | Sky Bet League One |
| 12 | 22/9/2021 | 10-3 v ArsenalArsenal 3-0 AFC Wimbledon | Carabao Cup Third Round |
| 13 | 25/9/2021 | 11-2 v Shrewsbury TownShrewsbury Town 2-1 AFC Wimbledon | Sky Bet League One |
| 14 | 28/9/2021 | 10-3 v Rotherham UnitedRotherham United 3-0 AFC Wimbledon | Sky Bet League One |
| 15 | 2/10/2021 | 11-1 v Burton AlbionAFC Wimbledon 1-1 Burton Albion | Sky Bet League One |
| 16 | 16/10/2021 | 12-2 v Sheffield WednesdayAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 17 | 19/10/2021 | 11-0 v Lincoln CityLincoln City 0-1 AFC Wimbledon | Sky Bet League One |
| 18 | 23/10/2021 | 10-2 v Wigan AthleticAFC Wimbledon 0-2 Wigan Athletic | Sky Bet League One |
| 19 | 30/10/2021 | 10-1 v Cambridge UnitedCambridge United 1-0 AFC Wimbledon | Sky Bet League One |
| 20 | 6/11/2021 | 11-0 v GuiseleyAFC Wimbledon 1-0 Guiseley | Emirates FA Cup First Round |
| 21 | 20/11/2021 | 11-2 v PortsmouthPortsmouth 2-1 AFC Wimbledon | Sky Bet League One |
| 22 | 23/11/2021 | 13-2 v Crewe AlexandraAFC Wimbledon 3-2 Crewe Alexandra | Sky Bet League One |
| 23 | 27/11/2021 | 12-2 v Fleetwood TownAFC Wimbledon 2-2 Fleetwood Town | Sky Bet League One |
| 24 | 4/12/2021 | 14-3 v Cheltenham TownAFC Wimbledon 4-3 Cheltenham Town | Emirates FA Cup Second Round |
| 25 | 7/12/2021 | 12-0 v Accrington StanleyAccrington Stanley 0-2 AFC Wimbledon | Sky Bet League One |
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