| 1 | 14/8/2021 | 65-0 v NEC NijmegenAjax 5-0 NEC Nijmegen | Dutch Eredivisie |
| 2 | 22/8/2021 | 6 1-1 v FC TwenteFC Twente 1-1 Ajax | Dutch Eredivisie |
| 3 | 29/8/2021 | 65-0 v VitesseAjax 5-0 Vitesse | Dutch Eredivisie |
| 4 | 25/9/2021 | 63-0 v FC GroningenAjax 3-0 FC Groningen | Dutch Eredivisie |
| 5 | 28/9/2021 | 62-0 v BeşiktaşAjax 2-0 Beşiktaş | UEFA Champions League Group C |
| 6 | 3/10/2021 | 60-1 v FC UtrechtAjax 0-1 FC Utrecht | Dutch Eredivisie |
| 7 | 16/10/2021 | 62-0 v sc Heerenveensc Heerenveen 0-2 Ajax | Dutch Eredivisie |
| 8 | 19/10/2021 | 64-0 v Borussia DortmundAjax 4-0 Borussia Dortmund | UEFA Champions League Group C |
| 9 | 24/10/2021 | 65-0 v PSV EindhovenAjax 5-0 PSV Eindhoven | Dutch Eredivisie |
| 10 | 30/10/2021 | 60-0 v Heracles AlmeloHeracles Almelo 0-0 Ajax | Dutch Eredivisie |
| 11 | 3/11/2021 | 63-1 v Borussia DortmundBorussia Dortmund 1-3 Ajax | UEFA Champions League Group C |
| 12 | 7/11/2021 | 60-0 v Go Ahead EaglesAjax 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 13 | 21/11/2021 | 65-0 v RKC WaalwijkRKC Waalwijk 0-5 Ajax | Dutch Eredivisie |
| 14 | 24/11/2021 | 62-1 v BeşiktaşBeşiktaş 1-2 Ajax | UEFA Champions League Group C |
| 15 | 28/11/2021 | 61-0 v Sparta RotterdamSparta Rotterdam 0-1 Ajax | Dutch Eredivisie |
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