| 1 | Sat 7 Aug 2021 | 71-1 v Cardiff CityCardiff City 1-1 Barnsley | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 71-0 v Coventry CityBarnsley 1-0 Coventry City | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 70-1 v Luton TownBarnsley 0-1 Luton Town | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 72-2 v Queens Park RangersQueens Park Rangers 2-2 Barnsley | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 71-1 v Birmingham CityBarnsley 1-1 Birmingham City | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 7 0-3 v AFC BournemouthAFC Bournemouth 3-0 Barnsley | Sky Bet Championship |
| 7 | Wed 15 Sep 2021 | 7 1-1 v Stoke CityStoke City 1-1 Barnsley | Sky Bet Championship |
| 8 | Sat 18 Sep 2021 | 70-0 v Blackburn RoversBarnsley 0-0 Blackburn Rovers | Sky Bet Championship |
| 9 | Sat 25 Sep 2021 | 70-1 v BlackpoolBlackpool 1-0 Barnsley | Sky Bet Championship |
| 10 | Wed 29 Sep 2021 | 71-3 v Nottingham ForestBarnsley 1-3 Nottingham Forest | Sky Bet Championship |
| 11 | Sat 2 Oct 2021 | 70-1 v MillwallBarnsley 0-1 Millwall | Sky Bet Championship |
| 12 | Sat 16 Oct 2021 | 7 0-1 v ReadingReading 1-0 Barnsley | Sky Bet Championship |
| 13 | Wed 20 Oct 2021 | 70-2 v MiddlesbroughMiddlesbrough 2-0 Barnsley | Sky Bet Championship |
| 14 | Sun 24 Oct 2021 | 72-3 v Sheffield UnitedBarnsley 2-3 Sheffield United | Sky Bet Championship |
| 15 | Sat 30 Oct 2021 | 71-2 v Bristol CityBristol City 2-1 Barnsley | Sky Bet Championship |
| 16 | Wed 3 Nov 2021 | 7 2-1 v Derby CountyBarnsley 2-1 Derby County | Sky Bet Championship |
| 17 | Sat 6 Nov 2021 | 7 0-2 v Hull CityBarnsley 0-2 Hull City | Sky Bet Championship |
| 18 | Wed 24 Nov 2021 | 7 0-2 v Swansea CityBarnsley 0-2 Swansea City | Sky Bet Championship |
| 19 | Sat 4 Dec 2021 | 71-1 v Huddersfield TownBarnsley 1-1 Huddersfield Town | Sky Bet Championship |
| 20 | Sat 11 Dec 2021 | 71-2 v Preston North EndPreston North End 2-1 Barnsley | Sky Bet Championship |
| 21 | Fri 17 Dec 2021 | 70-0 v West Bromwich AlbionBarnsley 0-0 West Bromwich Albion | Sky Bet Championship |
| 22 | Wed 29 Dec 2021 | 71-2 v Blackburn RoversBlackburn Rovers 2-1 Barnsley | Sky Bet Championship |
| 23 | Sat 8 Jan 2022 | 75-4 v BarrowBarnsley 5-4 Barrow | Emirates FA Cup Third Round |
| 24 | Sat 19 Feb 2022 | 70-1 v Coventry CityCoventry City 1-0 Barnsley | Sky Bet Championship |
| 25 | Tue 22 Feb 2022 | 72-0 v Hull CityHull City 0-2 Barnsley | Sky Bet Championship |
| 26 | Sat 26 Feb 2022 | 73-2 v MiddlesbroughBarnsley 3-2 Middlesbrough | Sky Bet Championship |
| 27 | Sat 5 Mar 2022 | 70-2 v Derby CountyDerby County 2-0 Barnsley | Sky Bet Championship |
| 28 | Tue 8 Mar 2022 | 71-1 v Stoke CityBarnsley 1-1 Stoke City | Sky Bet Championship |
| 29 | Sat 12 Mar 2022 | 71-1 v FulhamBarnsley 1-1 Fulham | Sky Bet Championship |
| 30 | Tue 15 Mar 2022 | 72-0 v Bristol CityBarnsley 2-0 Bristol City | Sky Bet Championship |
| 31 | Sat 19 Mar 2022 | 7 0-2 v Sheffield UnitedSheffield United 2-0 Barnsley | Sky Bet Championship |
| 32 | Sat 2 Apr 2022 | 7 1-1 v ReadingBarnsley 1-1 Reading | Sky Bet Championship |
| 33 | Sat 9 Apr 2022 | 71-4 v MillwallMillwall 4-1 Barnsley | Sky Bet Championship |
| 34 | Fri 15 Apr 2022 | 71-1 v Swansea CitySwansea City 1-1 Barnsley | Sky Bet Championship |
| 35 | Mon 18 Apr 2022 | 70-2 v Peterborough UnitedBarnsley 0-2 Peterborough United | Sky Bet Championship |
| 36 | Fri 22 Apr 2022 | 71-2 v Huddersfield TownHuddersfield Town 2-1 Barnsley | Sky Bet Championship |
| 37 | Tue 26 Apr 2022 | 70-2 v BlackpoolBarnsley 0-2 Blackpool | Sky Bet Championship |
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