| 1 | Sat 19 Aug | 253-2 v RB LeipzigBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 2 | Sat 26 Aug | 253-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 3 | Sat 2 Sep | 25 5-1 v Darmstadt 98Bayer 04 Leverkusen 5-1 Darmstadt 98 | German Bundesliga |
| 4 | Fri 15 Sep | 252-2 v Bayern MunichBayern Munich 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Thu 21 Sep | 254-0 v HäckenBayer 04 Leverkusen 4-0 Häcken | UEFA Europa League Group H |
| 6 | Sun 24 Sep | 25 4-1 v 1 FC HeidenheimBayer 04 Leverkusen 4-1 1 FC Heidenheim | German Bundesliga |
| 7 | Sat 30 Sep | 253-0 v Mainz 05Mainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 8 | Sun 8 Oct | 253-0 v 1 FC KölnBayer 04 Leverkusen 3-0 1 FC Köln | German Bundesliga |
| 9 | Sat 21 Oct | 25 2-1 v VfL WolfsburgVfL Wolfsburg 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 10 | Thu 26 Oct | 255-1 v FK QarabağBayer 04 Leverkusen 5-1 FK Qarabağ | UEFA Europa League Group H |
| 11 | Sun 29 Oct | 252-1 v SC FreiburgBayer 04 Leverkusen 2-1 SC Freiburg | German Bundesliga |
| 12 | Sat 4 Nov | 253-2 v 1899 Hoffenheim1899 Hoffenheim 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Sun 12 Nov | 254-0 v 1 FC Union BerlinBayer 04 Leverkusen 4-0 1 FC Union Berlin | German Bundesliga |
| 14 | Sat 25 Nov | 253-0 v Werder BremenWerder Bremen 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 15 | Sun 3 Dec | 25 1-1 v Borussia DortmundBayer 04 Leverkusen 1-1 Borussia Dortmund | German Bundesliga |
| 16 | Sun 10 Dec | 251-1 v VfB StuttgartVfB Stuttgart 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 17 | Sun 17 Dec | 25 3-0 v Eintracht FrankfurtBayer 04 Leverkusen 3-0 Eintracht Frankfurt | German Bundesliga |
| 18 | Sat 13 Jan | 251-0 v FC AugsburgFC Augsburg 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 19 | Sat 20 Jan | 253-2 v RB LeipzigRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 20 | Sun 3 Mar | 252-0 v 1 FC Köln1 FC Köln 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 21 | Thu 7 Mar | 252-2 v FK QarabağFK Qarabağ 2-2 Bayer 04 Leverkusen | UEFA Europa League Round of 16 |
| 22 | Sun 10 Mar | 252-0 v VfL WolfsburgBayer 04 Leverkusen 2-0 VfL Wolfsburg | German Bundesliga |
| 23 | Thu 14 Mar | 253-2 v FK QarabağBayer 04 Leverkusen 3-2 FK Qarabağ | UEFA Europa League Round of 16 |
| 24 | Sun 17 Mar | 253-2 v SC FreiburgSC Freiburg 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 25 | Thu 11 Apr | 252-0 v West Ham UnitedBayer 04 Leverkusen 2-0 West Ham United | UEFA Europa League Quarter Final |
| 26 | Sun 14 Apr | 255-0 v Werder BremenBayer 04 Leverkusen 5-0 Werder Bremen | German Bundesliga |
| 27 | Thu 18 Apr | 25 1-1 v West Ham UnitedWest Ham United 1-1 Bayer 04 Leverkusen | UEFA Europa League Quarter Final |
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