| 1 | Thu 19 Sep | 254-0 v FeyenoordFeyenoord 0-4 Bayer 04 Leverkusen | UEFA Champions League Matchday 1 |
| 2 | Sun 22 Sep | 254-3 v VfL WolfsburgBayer 04 Leverkusen 4-3 VfL Wolfsburg | German Bundesliga |
| 3 | Sat 28 Sep | 251-1 v Bayern MunichBayern Munich 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Tue 1 Oct | 251-0 v AC MilanBayer 04 Leverkusen 1-0 AC Milan | UEFA Champions League Matchday 2 |
| 5 | Sat 5 Oct | 252-2 v Holstein KielBayer 04 Leverkusen 2-2 Holstein Kiel | German Bundesliga |
| 6 | Wed 23 Oct | 251-1 v BrestBrest 1-1 Bayer 04 Leverkusen | UEFA Champions League Matchday 3 |
| 7 | Fri 1 Nov | 250-0 v VfB StuttgartBayer 04 Leverkusen 0-0 VfB Stuttgart | German Bundesliga |
| 8 | Tue 5 Nov | 250-4 v LiverpoolLiverpool 4-0 Bayer 04 Leverkusen | UEFA Champions League Matchday 4 |
| 9 | Sat 23 Nov | 255-2 v 1 FC HeidenheimBayer 04 Leverkusen 5-2 1 FC Heidenheim | German Bundesliga |
| 10 | Tue 26 Nov | 255-0 v SV Red Bull SalzburgBayer 04 Leverkusen 5-0 SV Red Bull Salzburg | UEFA Champions League Matchday 5 |
| 11 | Sat 30 Nov | 252-1 v 1 FC Union Berlin1 FC Union Berlin 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 12 | Sat 7 Dec | 252-1 v FC St PauliBayer 04 Leverkusen 2-1 FC St Pauli | German Bundesliga |
| 13 | Tue 10 Dec | 251-0 v Inter MilanBayer 04 Leverkusen 1-0 Inter Milan | UEFA Champions League Matchday 6 |
| 14 | Sat 14 Dec | 252-0 v FC AugsburgFC Augsburg 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 15 | Sat 21 Dec | 255-1 v SC FreiburgBayer 04 Leverkusen 5-1 SC Freiburg | German Bundesliga |
| 16 | Fri 10 Jan | 253-2 v Borussia DortmundBorussia Dortmund 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 17 | Tue 14 Jan | 251-0 v Mainz 05Bayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
| 18 | Sat 18 Jan | 253-1 v Borussia MönchengladbachBayer 04 Leverkusen 3-1 Borussia Mönchengladbach | German Bundesliga |
| 19 | Tue 21 Jan | 251-2 v Atlético MadridAtlético Madrid 2-1 Bayer 04 Leverkusen | UEFA Champions League Matchday 7 |
| 20 | Sat 25 Jan | 252-2 v RB LeipzigRB Leipzig 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 21 | Wed 29 Jan | 252-0 v Sparta PragueBayer 04 Leverkusen 2-0 Sparta Prague | UEFA Champions League Matchday 8 |
| 22 | Sun 2 Feb | 253-1 v 1899 HoffenheimBayer 04 Leverkusen 3-1 1899 Hoffenheim | German Bundesliga |
| 23 | Sat 15 Feb | 250-0 v Bayern MunichBayer 04 Leverkusen 0-0 Bayern Munich | German Bundesliga |
| 24 | Sat 1 Mar | 254-1 v Eintracht FrankfurtEintracht Frankfurt 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 25 | Wed 5 Mar | 250-3 v Bayern MunichBayern Munich 3-0 Bayer 04 Leverkusen | UEFA Champions League Round of 16 |
| 26 | Sat 8 Mar | 25 0-2 v Werder BremenBayer 04 Leverkusen 0-2 Werder Bremen | German Bundesliga |
| 27 | Tue 11 Mar | 250-2 v Bayern MunichBayer 04 Leverkusen 0-2 Bayern Munich | UEFA Champions League Round of 16 |
| 28 | Sun 16 Mar | 254-3 v VfB StuttgartVfB Stuttgart 3-4 Bayer 04 Leverkusen | German Bundesliga |
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