| 1 | Sat 19 Aug | 43-2 v RB LeipzigBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 2 | Sat 26 Aug | 4 3-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 3 | Sat 2 Sep | 4 5-1 v Darmstadt 98Bayer 04 Leverkusen 5-1 Darmstadt 98 | German Bundesliga |
| 4 | Fri 15 Sep | 42-2 v Bayern MunichBayern Munich 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Thu 21 Sep | 44-0 v HäckenBayer 04 Leverkusen 4-0 Häcken | UEFA Europa League Group H |
| 6 | Sun 24 Sep | 44-1 v 1 FC HeidenheimBayer 04 Leverkusen 4-1 1 FC Heidenheim | German Bundesliga |
| 7 | Sat 30 Sep | 43-0 v Mainz 05Mainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 8 | Thu 5 Oct | 42-1 v MoldeMolde 1-2 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 9 | Sun 8 Oct | 4 3-0 v 1 FC KölnBayer 04 Leverkusen 3-0 1 FC Köln | German Bundesliga |
| 10 | Sat 21 Oct | 42-1 v VfL WolfsburgVfL Wolfsburg 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 11 | Sun 29 Oct | 42-1 v SC FreiburgBayer 04 Leverkusen 2-1 SC Freiburg | German Bundesliga |
| 12 | Sat 4 Nov | 4 3-2 v 1899 Hoffenheim1899 Hoffenheim 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Thu 9 Nov | 41-0 v FK QarabağFK Qarabağ 0-1 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 14 | Sun 12 Nov | 44-0 v 1 FC Union BerlinBayer 04 Leverkusen 4-0 1 FC Union Berlin | German Bundesliga |
| 15 | Thu 30 Nov | 42-0 v HäckenHäcken 0-2 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 16 | Sun 3 Dec | 41-1 v Borussia DortmundBayer 04 Leverkusen 1-1 Borussia Dortmund | German Bundesliga |
| 17 | Sun 10 Dec | 41-1 v VfB StuttgartVfB Stuttgart 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Thu 14 Dec | 4 5-1 v MoldeBayer 04 Leverkusen 5-1 Molde | UEFA Europa League Group H |
| 19 | Sun 17 Dec | 43-0 v Eintracht FrankfurtBayer 04 Leverkusen 3-0 Eintracht Frankfurt | German Bundesliga |
| 20 | Wed 20 Dec | 44-0 v VfL BochumBayer 04 Leverkusen 4-0 VfL Bochum | German Bundesliga |
| 21 | Sat 20 Jan | 4 3-2 v RB LeipzigRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 22 | Sat 3 Feb | 42-0 v Darmstadt 98Darmstadt 98 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 23 | Sat 10 Feb | 43-0 v Bayern MunichBayer 04 Leverkusen 3-0 Bayern Munich | German Bundesliga |
| 24 | Sat 17 Feb | 42-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 25 | Fri 23 Feb | 4 2-1 v Mainz 05Bayer 04 Leverkusen 2-1 Mainz 05 | German Bundesliga |
| 26 | Sun 3 Mar | 42-0 v 1 FC Köln1 FC Köln 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 27 | Thu 7 Mar | 42-2 v FK QarabağFK Qarabağ 2-2 Bayer 04 Leverkusen | UEFA Europa League Round of 16 |
| 28 | Sun 10 Mar | 42-0 v VfL WolfsburgBayer 04 Leverkusen 2-0 VfL Wolfsburg | German Bundesliga |
| 29 | Sun 17 Mar | 43-2 v SC FreiburgSC Freiburg 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 30 | Sat 30 Mar | 42-1 v 1899 HoffenheimBayer 04 Leverkusen 2-1 1899 Hoffenheim | German Bundesliga |
| 31 | Sat 6 Apr | 41-0 v 1 FC Union Berlin1 FC Union Berlin 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 32 | Thu 11 Apr | 42-0 v West Ham UnitedBayer 04 Leverkusen 2-0 West Ham United | UEFA Europa League Quarter Final |
| 33 | Sun 14 Apr | 45-0 v Werder BremenBayer 04 Leverkusen 5-0 Werder Bremen | German Bundesliga |
| 34 | Thu 18 Apr | 4 1-1 v West Ham UnitedWest Ham United 1-1 Bayer 04 Leverkusen | UEFA Europa League Quarter Final |
| 35 | Sun 21 Apr | 41-1 v Borussia DortmundBorussia Dortmund 1-1 Bayer 04 Leverkusen | German Bundesliga |
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