| 1 | 17/8/2019 | 13-2 v SC Paderborn 07Bayer 04 Leverkusen 3-2 SC Paderborn 07 | German Bundesliga |
| 2 | 24/8/2019 | 13-1 v Fortuna DüsseldorfFortuna Düsseldorf 1-3 Bayer 04 Leverkusen | German Bundesliga |
| 3 | 31/8/2019 | 10-0 v 1899 HoffenheimBayer 04 Leverkusen 0-0 1899 Hoffenheim | German Bundesliga |
| 4 | 14/9/2019 | 10-4 v Borussia DortmundBorussia Dortmund 4-0 Bayer 04 Leverkusen | German Bundesliga |
| 5 | 18/9/2019 | 11-2 v Lokomotiv MoscowBayer 04 Leverkusen 1-2 Lokomotiv Moscow | UEFA Champions League Group D |
| 6 | 21/9/2019 | 12-0 v 1. FC Union BerlinBayer 04 Leverkusen 2-0 1. FC Union Berlin | German Bundesliga |
| 7 | 28/9/2019 | 13-0 v FC AugsburgFC Augsburg 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 8 | 1/10/2019 | 10-3 v JuventusJuventus 3-0 Bayer 04 Leverkusen | UEFA Champions League Group D |
| 9 | 5/10/2019 | 11-1 v RB LeipzigBayer 04 Leverkusen 1-1 RB Leipzig | German Bundesliga |
| 10 | 18/10/2019 | 10-3 v Eintracht FrankfurtEintracht Frankfurt 3-0 Bayer 04 Leverkusen | German Bundesliga |
| 11 | 22/10/2019 | 10-1 v Atlético MadridAtlético Madrid 1-0 Bayer 04 Leverkusen | UEFA Champions League Group D |
| 12 | 26/10/2019 | 12-2 v Werder BremenBayer 04 Leverkusen 2-2 Werder Bremen | German Bundesliga |
| 13 | 2/11/2019 | 11-2 v Borussia MönchengladbachBayer 04 Leverkusen 1-2 Borussia Mönchengladbach | German Bundesliga |
| 14 | 6/11/2019 | 12-1 v Atlético MadridBayer 04 Leverkusen 2-1 Atlético Madrid | UEFA Champions League Group D |
| 15 | 10/11/2019 | 1 2-0 v VfL WolfsburgVfL Wolfsburg 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 16 | 23/11/2019 | 11-1 v SC FreiburgBayer 04 Leverkusen 1-1 SC Freiburg | German Bundesliga |
| 17 | 26/11/2019 | 12-0 v Lokomotiv MoscowLokomotiv Moscow 0-2 Bayer 04 Leverkusen | UEFA Champions League Group D |
| 18 | 30/11/2019 | 12-1 v Bayern MunichBayern Munich 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 19 | 7/12/2019 | 12-1 v FC Schalke 04Bayer 04 Leverkusen 2-1 FC Schalke 04 | German Bundesliga |
| 20 | 11/12/2019 | 10-2 v JuventusBayer 04 Leverkusen 0-2 Juventus | UEFA Champions League Group D |
