| 1 | Fri 23 Aug | 113-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sat 31 Aug | 112-3 v RB LeipzigBayer 04 Leverkusen 2-3 RB Leipzig | German Bundesliga |
| 3 | Sat 14 Sep | 11 4-1 v 1899 Hoffenheim1899 Hoffenheim 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Thu 19 Sep | 114-0 v FeyenoordFeyenoord 0-4 Bayer 04 Leverkusen | UEFA Champions League Matchday 1 |
| 5 | Sun 22 Sep | 114-3 v VfL WolfsburgBayer 04 Leverkusen 4-3 VfL Wolfsburg | German Bundesliga |
| 6 | Sat 28 Sep | 111-1 v Bayern MunichBayern Munich 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Tue 1 Oct | 111-0 v AC MilanBayer 04 Leverkusen 1-0 AC Milan | UEFA Champions League Matchday 2 |
| 8 | Sat 5 Oct | 112-2 v Holstein KielBayer 04 Leverkusen 2-2 Holstein Kiel | German Bundesliga |
| 9 | Sat 19 Oct | 112-1 v Eintracht FrankfurtBayer 04 Leverkusen 2-1 Eintracht Frankfurt | German Bundesliga |
| 10 | Wed 23 Oct | 111-1 v BrestBrest 1-1 Bayer 04 Leverkusen | UEFA Champions League Matchday 3 |
| 11 | Sat 26 Oct | 112-2 v Werder BremenWerder Bremen 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 12 | Sat 23 Nov | 115-2 v 1 FC HeidenheimBayer 04 Leverkusen 5-2 1 FC Heidenheim | German Bundesliga |
| 13 | Sat 7 Dec | 112-1 v FC St PauliBayer 04 Leverkusen 2-1 FC St Pauli | German Bundesliga |
| 14 | Tue 10 Dec | 111-0 v Inter MilanBayer 04 Leverkusen 1-0 Inter Milan | UEFA Champions League Matchday 6 |
| 15 | Sat 14 Dec | 112-0 v FC AugsburgFC Augsburg 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 16 | Sat 21 Dec | 115-1 v SC FreiburgBayer 04 Leverkusen 5-1 SC Freiburg | German Bundesliga |
| 17 | Fri 10 Jan | 113-2 v Borussia DortmundBorussia Dortmund 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Tue 14 Jan | 111-0 v Mainz 05Bayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
| 19 | Sat 18 Jan | 113-1 v Borussia MönchengladbachBayer 04 Leverkusen 3-1 Borussia Mönchengladbach | German Bundesliga |
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