| 1 | Sat 14 Sep | 234-1 v 1899 Hoffenheim1899 Hoffenheim 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sun 22 Sep | 234-3 v VfL WolfsburgBayer 04 Leverkusen 4-3 VfL Wolfsburg | German Bundesliga |
| 3 | Wed 23 Oct | 231-1 v BrestBrest 1-1 Bayer 04 Leverkusen | UEFA Champions League Matchday 3 |
| 4 | Fri 1 Nov | 23 0-0 v VfB StuttgartBayer 04 Leverkusen 0-0 VfB Stuttgart | German Bundesliga |
| 5 | Tue 10 Dec | 231-0 v Inter MilanBayer 04 Leverkusen 1-0 Inter Milan | UEFA Champions League Matchday 6 |
| 6 | Sat 21 Dec | 235-1 v SC FreiburgBayer 04 Leverkusen 5-1 SC Freiburg | German Bundesliga |
| 7 | Fri 10 Jan | 233-2 v Borussia DortmundBorussia Dortmund 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 8 | Tue 14 Jan | 23 1-0 v Mainz 05Bayer 04 Leverkusen 1-0 Mainz 05 | German Bundesliga |
| 9 | Tue 21 Jan | 231-2 v Atlético MadridAtlético Madrid 2-1 Bayer 04 Leverkusen | UEFA Champions League Matchday 7 |
| 10 | Sat 25 Jan | 232-2 v RB LeipzigRB Leipzig 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 11 | Wed 29 Jan | 232-0 v Sparta PragueBayer 04 Leverkusen 2-0 Sparta Prague | UEFA Champions League Matchday 8 |
| 12 | Sat 8 Feb | 23 0-0 v VfL WolfsburgVfL Wolfsburg 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Sat 15 Feb | 230-0 v Bayern MunichBayer 04 Leverkusen 0-0 Bayern Munich | German Bundesliga |
| 14 | Sat 22 Feb | 232-0 v Holstein KielHolstein Kiel 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 15 | Sat 1 Mar | 234-1 v Eintracht FrankfurtEintracht Frankfurt 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 16 | Wed 5 Mar | 23 0-3 v Bayern MunichBayern Munich 3-0 Bayer 04 Leverkusen | UEFA Champions League Round of 16 |
| 17 | Sat 8 Mar | 230-2 v Werder BremenBayer 04 Leverkusen 0-2 Werder Bremen | German Bundesliga |
| 18 | Sun 16 Mar | 234-3 v VfB StuttgartVfB Stuttgart 3-4 Bayer 04 Leverkusen | German Bundesliga |
| 19 | Fri 28 Mar | 233-1 v VfL BochumBayer 04 Leverkusen 3-1 VfL Bochum | German Bundesliga |
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