| 1 | Sat 19 Aug | 83-2 v RB LeipzigBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 2 | Sat 26 Aug | 83-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 3 | Sat 2 Sep | 85-1 v Darmstadt 98Bayer 04 Leverkusen 5-1 Darmstadt 98 | German Bundesliga |
| 4 | Fri 15 Sep | 82-2 v Bayern MunichBayern Munich 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Thu 21 Sep | 84-0 v HäckenBayer 04 Leverkusen 4-0 Häcken | UEFA Europa League Group H |
| 6 | Sun 24 Sep | 84-1 v 1 FC HeidenheimBayer 04 Leverkusen 4-1 1 FC Heidenheim | German Bundesliga |
| 7 | Sat 30 Sep | 83-0 v Mainz 05Mainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 8 | Thu 5 Oct | 82-1 v MoldeMolde 1-2 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 9 | Thu 26 Oct | 8 5-1 v FK QarabağBayer 04 Leverkusen 5-1 FK Qarabağ | UEFA Europa League Group H |
| 10 | Sat 4 Nov | 83-2 v 1899 Hoffenheim1899 Hoffenheim 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 11 | Thu 9 Nov | 81-0 v FK QarabağFK Qarabağ 0-1 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 12 | Sun 12 Nov | 84-0 v 1 FC Union BerlinBayer 04 Leverkusen 4-0 1 FC Union Berlin | German Bundesliga |
| 13 | Sat 25 Nov | 83-0 v Werder BremenWerder Bremen 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 14 | Thu 30 Nov | 82-0 v HäckenHäcken 0-2 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 15 | Thu 14 Dec | 85-1 v MoldeBayer 04 Leverkusen 5-1 Molde | UEFA Europa League Group H |
| 16 | Wed 20 Dec | 84-0 v VfL BochumBayer 04 Leverkusen 4-0 VfL Bochum | German Bundesliga |
| 17 | Sat 13 Jan | 81-0 v FC AugsburgFC Augsburg 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Sat 20 Jan | 83-2 v RB LeipzigRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 19 | Sat 27 Jan | 80-0 v Borussia MönchengladbachBayer 04 Leverkusen 0-0 Borussia Mönchengladbach | German Bundesliga |
| 20 | Sat 3 Feb | 8 2-0 v Darmstadt 98Darmstadt 98 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 21 | Sat 10 Feb | 83-0 v Bayern MunichBayer 04 Leverkusen 3-0 Bayern Munich | German Bundesliga |
| 22 | Sat 17 Feb | 8 2-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 23 | Fri 23 Feb | 82-1 v Mainz 05Bayer 04 Leverkusen 2-1 Mainz 05 | German Bundesliga |
| 24 | Sun 3 Mar | 82-0 v 1 FC Köln1 FC Köln 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 25 | Thu 7 Mar | 82-2 v FK QarabağFK Qarabağ 2-2 Bayer 04 Leverkusen | UEFA Europa League Round of 16 |
| 26 | Sun 10 Mar | 82-0 v VfL WolfsburgBayer 04 Leverkusen 2-0 VfL Wolfsburg | German Bundesliga |
| 27 | Thu 14 Mar | 83-2 v FK QarabağBayer 04 Leverkusen 3-2 FK Qarabağ | UEFA Europa League Round of 16 |
| 28 | Sun 17 Mar | 83-2 v SC FreiburgSC Freiburg 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 29 | Sat 30 Mar | 82-1 v 1899 HoffenheimBayer 04 Leverkusen 2-1 1899 Hoffenheim | German Bundesliga |
| 30 | Sat 6 Apr | 8 1-0 v 1 FC Union Berlin1 FC Union Berlin 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 31 | Sun 14 Apr | 85-0 v Werder BremenBayer 04 Leverkusen 5-0 Werder Bremen | German Bundesliga |
| 32 | Thu 18 Apr | 81-1 v West Ham UnitedWest Ham United 1-1 Bayer 04 Leverkusen | UEFA Europa League Quarter Final |
| 33 | Sun 21 Apr | 81-1 v Borussia DortmundBorussia Dortmund 1-1 Bayer 04 Leverkusen | German Bundesliga |
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