| 1 | Fri 23 Aug | 223-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sat 31 Aug | 22 2-3 v RB LeipzigBayer 04 Leverkusen 2-3 RB Leipzig | German Bundesliga |
| 3 | Sat 14 Sep | 224-1 v 1899 Hoffenheim1899 Hoffenheim 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Thu 19 Sep | 224-0 v FeyenoordFeyenoord 0-4 Bayer 04 Leverkusen | UEFA Champions League Matchday 1 |
| 5 | Sun 22 Sep | 224-3 v VfL WolfsburgBayer 04 Leverkusen 4-3 VfL Wolfsburg | German Bundesliga |
| 6 | Sat 28 Sep | 221-1 v Bayern MunichBayern Munich 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Tue 1 Oct | 221-0 v AC MilanBayer 04 Leverkusen 1-0 AC Milan | UEFA Champions League Matchday 2 |
| 8 | Sat 5 Oct | 222-2 v Holstein KielBayer 04 Leverkusen 2-2 Holstein Kiel | German Bundesliga |
| 9 | Sat 19 Oct | 222-1 v Eintracht FrankfurtBayer 04 Leverkusen 2-1 Eintracht Frankfurt | German Bundesliga |
| 10 | Sat 26 Oct | 222-2 v Werder BremenWerder Bremen 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 11 | Fri 1 Nov | 220-0 v VfB StuttgartBayer 04 Leverkusen 0-0 VfB Stuttgart | German Bundesliga |
| 12 | Tue 5 Nov | 220-4 v LiverpoolLiverpool 4-0 Bayer 04 Leverkusen | UEFA Champions League Matchday 4 |
| 13 | Sat 9 Nov | 221-1 v VfL BochumVfL Bochum 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 14 | Sun 2 Feb | 223-1 v 1899 HoffenheimBayer 04 Leverkusen 3-1 1899 Hoffenheim | German Bundesliga |
| 15 | Sat 8 Feb | 22 0-0 v VfL WolfsburgVfL Wolfsburg 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 16 | Sat 22 Feb | 222-0 v Holstein KielHolstein Kiel 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 17 | Sat 1 Mar | 224-1 v Eintracht FrankfurtEintracht Frankfurt 1-4 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Sun 16 Mar | 224-3 v VfB StuttgartVfB Stuttgart 3-4 Bayer 04 Leverkusen | German Bundesliga |
| 19 | Fri 28 Mar | 223-1 v VfL BochumBayer 04 Leverkusen 3-1 VfL Bochum | German Bundesliga |
| 20 | Sat 5 Apr | 221-0 v 1 FC Heidenheim1 FC Heidenheim 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 21 | Sat 12 Apr | 220-0 v 1 FC Union BerlinBayer 04 Leverkusen 0-0 1 FC Union Berlin | German Bundesliga |
| 22 | Sun 20 Apr | 221-1 v FC St PauliFC St Pauli 1-1 Bayer 04 Leverkusen | German Bundesliga |
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