| 1 | Fri 15 Sep | 32-2 v Bayern MunichBayern Munich 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Thu 21 Sep | 34-0 v HäckenBayer 04 Leverkusen 4-0 Häcken | UEFA Europa League Group H |
| 3 | Sun 24 Sep | 34-1 v 1 FC HeidenheimBayer 04 Leverkusen 4-1 1 FC Heidenheim | German Bundesliga |
| 4 | Thu 5 Oct | 32-1 v MoldeMolde 1-2 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 5 | Sun 8 Oct | 33-0 v 1 FC KölnBayer 04 Leverkusen 3-0 1 FC Köln | German Bundesliga |
| 6 | Thu 26 Oct | 35-1 v FK QarabağBayer 04 Leverkusen 5-1 FK Qarabağ | UEFA Europa League Group H |
| 7 | Sun 29 Oct | 32-1 v SC FreiburgBayer 04 Leverkusen 2-1 SC Freiburg | German Bundesliga |
| 8 | Thu 9 Nov | 31-0 v FK QarabağFK Qarabağ 0-1 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 9 | Sun 12 Nov | 34-0 v 1 FC Union BerlinBayer 04 Leverkusen 4-0 1 FC Union Berlin | German Bundesliga |
| 10 | Sat 25 Nov | 33-0 v Werder BremenWerder Bremen 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 11 | Thu 30 Nov | 32-0 v HäckenHäcken 0-2 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 12 | Sun 10 Dec | 31-1 v VfB StuttgartVfB Stuttgart 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Thu 14 Dec | 35-1 v MoldeBayer 04 Leverkusen 5-1 Molde | UEFA Europa League Group H |
| 14 | Sun 17 Dec | 33-0 v Eintracht FrankfurtBayer 04 Leverkusen 3-0 Eintracht Frankfurt | German Bundesliga |
| 15 | Wed 20 Dec | 34-0 v VfL BochumBayer 04 Leverkusen 4-0 VfL Bochum | German Bundesliga |
| 16 | Sat 13 Jan | 31-0 v FC AugsburgFC Augsburg 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 17 | Sat 20 Jan | 33-2 v RB LeipzigRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Sat 27 Jan | 30-0 v Borussia MönchengladbachBayer 04 Leverkusen 0-0 Borussia Mönchengladbach | German Bundesliga |
| 19 | Sat 3 Feb | 32-0 v Darmstadt 98Darmstadt 98 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 20 | Sat 10 Feb | 33-0 v Bayern MunichBayer 04 Leverkusen 3-0 Bayern Munich | German Bundesliga |
| 21 | Sat 17 Feb | 32-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 22 | Fri 23 Feb | 32-1 v Mainz 05Bayer 04 Leverkusen 2-1 Mainz 05 | German Bundesliga |
| 23 | Sun 3 Mar | 32-0 v 1 FC Köln1 FC Köln 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 24 | Sun 10 Mar | 32-0 v VfL WolfsburgBayer 04 Leverkusen 2-0 VfL Wolfsburg | German Bundesliga |
| 25 | Thu 14 Mar | 33-2 v FK QarabağBayer 04 Leverkusen 3-2 FK Qarabağ | UEFA Europa League Round of 16 |
| 26 | Sun 17 Mar | 33-2 v SC FreiburgSC Freiburg 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 27 | Sat 30 Mar | 32-1 v 1899 HoffenheimBayer 04 Leverkusen 2-1 1899 Hoffenheim | German Bundesliga |
| 28 | Sat 6 Apr | 31-0 v 1 FC Union Berlin1 FC Union Berlin 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 29 | Thu 11 Apr | 32-0 v West Ham UnitedBayer 04 Leverkusen 2-0 West Ham United | UEFA Europa League Quarter Final |
| 30 | Sun 14 Apr | 3 5-0 v Werder BremenBayer 04 Leverkusen 5-0 Werder Bremen | German Bundesliga |
| 31 | Thu 18 Apr | 31-1 v West Ham UnitedWest Ham United 1-1 Bayer 04 Leverkusen | UEFA Europa League Quarter Final |
| 32 | Sun 21 Apr | 31-1 v Borussia DortmundBorussia Dortmund 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 33 | Sat 27 Apr | 3 2-2 v VfB StuttgartBayer 04 Leverkusen 2-2 VfB Stuttgart | German Bundesliga |
| 34 | Thu 2 May | 32-0 v RomaRoma 0-2 Bayer 04 Leverkusen | UEFA Europa League Semi Final |
| 35 | Thu 9 May | 32-2 v RomaBayer 04 Leverkusen 2-2 Roma | UEFA Europa League Semi Final |
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