| 1 | Sun 20 Aug | 3 1-4 v 1 FC Union Berlin1 FC Union Berlin 4-1 Mainz 05 | German Bundesliga |
| 2 | Sun 27 Aug | 3 1-1 v Eintracht FrankfurtMainz 05 1-1 Eintracht Frankfurt | German Bundesliga |
| 3 | Sat 2 Sep | 3 0-4 v Werder BremenWerder Bremen 4-0 Mainz 05 | German Bundesliga |
| 4 | Sat 16 Sep | 31-3 v VfB StuttgartMainz 05 1-3 VfB Stuttgart | German Bundesliga |
| 5 | Sat 23 Sep | 31-2 v FC AugsburgFC Augsburg 2-1 Mainz 05 | German Bundesliga |
| 6 | Sat 30 Sep | 30-3 v Bayer 04 LeverkusenMainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Fri 6 Oct | 32-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-2 Mainz 05 | German Bundesliga |
| 8 | Sat 21 Oct | 31-3 v Bayern MunichMainz 05 1-3 Bayern Munich | German Bundesliga |
| 9 | Fri 27 Oct | 32-2 v VfL BochumVfL Bochum 2-2 Mainz 05 | German Bundesliga |
| 10 | Sat 4 Nov | 3 2-0 v RB LeipzigMainz 05 2-0 RB Leipzig | German Bundesliga |
| 11 | Sat 11 Nov | 3 0-0 v Darmstadt 98Darmstadt 98 0-0 Mainz 05 | German Bundesliga |
| 12 | Sun 3 Dec | 30-1 v SC FreiburgMainz 05 0-1 SC Freiburg | German Bundesliga |
| 13 | Sun 10 Dec | 30-0 v 1 FC Köln1 FC Köln 0-0 Mainz 05 | German Bundesliga |
| 14 | Sat 16 Dec | 30-1 v 1 FC HeidenheimMainz 05 0-1 1 FC Heidenheim | German Bundesliga |
| 15 | Tue 19 Dec | 31-1 v Borussia DortmundBorussia Dortmund 1-1 Mainz 05 | German Bundesliga |
| 16 | Sat 13 Jan | 3 1-1 v VfL WolfsburgMainz 05 1-1 VfL Wolfsburg | German Bundesliga |
| 17 | Fri 26 Jan | 30-1 v Eintracht FrankfurtEintracht Frankfurt 1-0 Mainz 05 | German Bundesliga |
| 18 | Sat 3 Feb | 30-1 v Werder BremenMainz 05 0-1 Werder Bremen | German Bundesliga |
| 19 | Wed 7 Feb | 31-1 v 1 FC Union BerlinMainz 05 1-1 1 FC Union Berlin | German Bundesliga |
| 20 | Sun 11 Feb | 31-3 v VfB StuttgartVfB Stuttgart 3-1 Mainz 05 | German Bundesliga |
| 21 | Sat 17 Feb | 3 1-0 v FC AugsburgMainz 05 1-0 FC Augsburg | German Bundesliga |
| 22 | Fri 23 Feb | 31-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-1 Mainz 05 | German Bundesliga |
| 23 | Sat 2 Mar | 31-1 v Borussia MönchengladbachMainz 05 1-1 Borussia Mönchengladbach | German Bundesliga |
| 24 | Sat 9 Mar | 31-8 v Bayern MunichBayern Munich 8-1 Mainz 05 | German Bundesliga |
| 25 | Sat 16 Mar | 3 2-0 v VfL BochumMainz 05 2-0 VfL Bochum | German Bundesliga |
| 26 | Sat 30 Mar | 30-0 v RB LeipzigRB Leipzig 0-0 Mainz 05 | German Bundesliga |
| 27 | Sat 6 Apr | 34-0 v Darmstadt 98Mainz 05 4-0 Darmstadt 98 | German Bundesliga |
| 28 | Sat 13 Apr | 34-1 v 1899 HoffenheimMainz 05 4-1 1899 Hoffenheim | German Bundesliga |
| 29 | Sun 21 Apr | 3 1-1 v SC FreiburgSC Freiburg 1-1 Mainz 05 | German Bundesliga |
| 30 | Sun 28 Apr | 31-1 v 1 FC KölnMainz 05 1-1 1 FC Köln | German Bundesliga |
| 31 | Sun 5 May | 31-1 v 1 FC Heidenheim1 FC Heidenheim 1-1 Mainz 05 | German Bundesliga |
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