| 1 | Fri 24 Mar | 120-4 v FranceFrance 4-0 Netherlands | European Championship Qualification Group B |
| 2 | Mon 27 Mar | 123-0 v GibraltarNetherlands 3-0 Gibraltar | European Championship Qualification Group B |
| 3 | Sat 19 Aug | 202-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 4 | Fri 25 Aug | 205-1 v VfB StuttgartRB Leipzig 5-1 VfB Stuttgart | German Bundesliga |
| 5 | Sun 3 Sep | 203-0 v 1 FC Union Berlin1 FC Union Berlin 0-3 RB Leipzig | German Bundesliga |
| 6 | Thu 7 Sep | 73-0 v GreeceNetherlands 3-0 Greece | European Championship Qualification Group B |
| 7 | Sun 10 Sep | 72-1 v Republic of IrelandRepublic of Ireland 1-2 Netherlands | European Championship Qualification Group B |
| 8 | Sat 16 Sep | 203-0 v FC AugsburgRB Leipzig 3-0 FC Augsburg | German Bundesliga |
| 9 | Tue 19 Sep | 20 3-1 v Young BoysYoung Boys 1-3 RB Leipzig | UEFA Champions League Group G |
| 10 | Sat 23 Sep | 201-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 RB Leipzig | German Bundesliga |
| 11 | Sat 30 Sep | 202-2 v Bayern MunichRB Leipzig 2-2 Bayern Munich | German Bundesliga |
| 12 | Wed 4 Oct | 201-3 v Manchester CityRB Leipzig 1-3 Manchester City | UEFA Champions League Group G |
| 13 | Sat 7 Oct | 20 0-0 v VfL BochumRB Leipzig 0-0 VfL Bochum | German Bundesliga |
| 14 | Fri 13 Oct | 101-2 v FranceNetherlands 1-2 France | European Championship Qualification Group B |
| 15 | Mon 16 Oct | 10 1-0 v GreeceGreece 0-1 Netherlands | European Championship Qualification Group B |
| 16 | Sat 21 Oct | 203-1 v Darmstadt 98Darmstadt 98 1-3 RB Leipzig | German Bundesliga |
| 17 | Wed 25 Oct | 203-1 v Red Star BelgradeRB Leipzig 3-1 Red Star Belgrade | UEFA Champions League Group G |
| 18 | Sat 28 Oct | 206-0 v 1 FC KölnRB Leipzig 6-0 1 FC Köln | German Bundesliga |
| 19 | Sat 4 Nov | 200-2 v Mainz 05Mainz 05 2-0 RB Leipzig | German Bundesliga |
| 20 | Tue 7 Nov | 202-1 v Red Star BelgradeRed Star Belgrade 1-2 RB Leipzig | UEFA Champions League Group G |
| 21 | Sun 12 Nov | 203-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg | German Bundesliga |
| 22 | Sat 18 Nov | 101-0 v Republic of IrelandNetherlands 1-0 Republic of Ireland | European Championship Qualification Group B |
| 23 | Tue 21 Nov | 106-0 v GibraltarGibraltar 0-6 Netherlands | European Championship Qualification Group B |
| 24 | Sat 25 Nov | 20 1-2 v VfL WolfsburgVfL Wolfsburg 2-1 RB Leipzig | German Bundesliga |
| 25 | Tue 28 Nov | 202-3 v Manchester CityManchester City 3-2 RB Leipzig | UEFA Champions League Group G |
| 26 | Sat 2 Dec | 202-1 v 1 FC HeidenheimRB Leipzig 2-1 1 FC Heidenheim | German Bundesliga |
| 27 | Sat 9 Dec | 20 3-2 v Borussia DortmundBorussia Dortmund 2-3 RB Leipzig | German Bundesliga |
| 28 | Wed 13 Dec | 202-1 v Young BoysRB Leipzig 2-1 Young Boys | UEFA Champions League Group G |
| 29 | Sat 16 Dec | 20 3-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 30 | Tue 19 Dec | 201-1 v Werder BremenWerder Bremen 1-1 RB Leipzig | German Bundesliga |
| 31 | Sat 13 Jan | 200-1 v Eintracht FrankfurtRB Leipzig 0-1 Eintracht Frankfurt | German Bundesliga |
| 32 | Sat 20 Jan | 20 2-3 v Bayer 04 LeverkusenRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 33 | Sun 4 Feb | 202-0 v 1 FC Union BerlinRB Leipzig 2-0 1 FC Union Berlin | German Bundesliga |
| 34 | Sat 10 Feb | 202-2 v FC AugsburgFC Augsburg 2-2 RB Leipzig | German Bundesliga |
| 35 | Tue 13 Feb | 200-1 v Real MadridRB Leipzig 0-1 Real Madrid | UEFA Champions League Round of 16 |
| 36 | Sat 17 Feb | 202-0 v Borussia MönchengladbachRB Leipzig 2-0 Borussia Mönchengladbach | German Bundesliga |
| 37 | Sat 24 Feb | 201-2 v Bayern MunichBayern Munich 2-1 RB Leipzig | German Bundesliga |
| 38 | Sat 2 Mar | 204-1 v VfL BochumVfL Bochum 1-4 RB Leipzig | German Bundesliga |
| 39 | Wed 6 Mar | 201-1 v Real MadridReal Madrid 1-1 RB Leipzig | UEFA Champions League Round of 16 |
| 40 | Sat 9 Mar | 202-0 v Darmstadt 98RB Leipzig 2-0 Darmstadt 98 | German Bundesliga |
| 41 | Fri 15 Mar | 20 5-1 v 1 FC Köln1 FC Köln 1-5 RB Leipzig | German Bundesliga |
| 42 | Fri 22 Mar | 74-0 v ScotlandNetherlands 4-0 Scotland | International Friendly |
| 43 | Tue 26 Mar | 71-2 v GermanyGermany 2-1 Netherlands | International Friendly |
| 44 | Sat 30 Mar | 20 0-0 v Mainz 05RB Leipzig 0-0 Mainz 05 | German Bundesliga |
| 45 | Sat 6 Apr | 204-1 v SC FreiburgSC Freiburg 1-4 RB Leipzig | German Bundesliga |
| 46 | Sat 13 Apr | 20 3-0 v VfL WolfsburgRB Leipzig 3-0 VfL Wolfsburg | German Bundesliga |
| 47 | Sat 20 Apr | 202-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 RB Leipzig | German Bundesliga |
| 48 | Sat 27 Apr | 204-1 v Borussia DortmundRB Leipzig 4-1 Borussia Dortmund | German Bundesliga |
| 49 | Fri 3 May | 20 1-1 v 1899 Hoffenheim1899 Hoffenheim 1-1 RB Leipzig | German Bundesliga |
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