| 1 | Tue 12 Sep | 211-0 v Burkina FasoMorocco 1-0 Burkina Faso | International Friendly |
| 2 | Fri 15 Sep | 212-2 v Bayern MunichBayern Munich 2-2 Bayer 04 Leverkusen | German Bundesliga |
| 3 | Thu 21 Sep | 214-0 v HäckenBayer 04 Leverkusen 4-0 Häcken | UEFA Europa League Group H |
| 4 | Sun 24 Sep | 214-1 v 1 FC HeidenheimBayer 04 Leverkusen 4-1 1 FC Heidenheim | German Bundesliga |
| 5 | Sat 30 Sep | 213-0 v Mainz 05Mainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 6 | Thu 5 Oct | 212-1 v MoldeMolde 1-2 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 7 | Sun 8 Oct | 213-0 v 1 FC KölnBayer 04 Leverkusen 3-0 1 FC Köln | German Bundesliga |
| 8 | Sat 14 Oct | 211-1 v Côte d'IvoireCôte d'Ivoire 1-1 Morocco | International Friendly |
| 9 | Sat 21 Oct | 21 2-1 v VfL WolfsburgVfL Wolfsburg 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 10 | Thu 26 Oct | 215-1 v FK QarabağBayer 04 Leverkusen 5-1 FK Qarabağ | UEFA Europa League Group H |
| 11 | Sun 29 Oct | 212-1 v SC FreiburgBayer 04 Leverkusen 2-1 SC Freiburg | German Bundesliga |
| 12 | Sat 4 Nov | 213-2 v 1899 Hoffenheim1899 Hoffenheim 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Thu 9 Nov | 211-0 v FK QarabağFK Qarabağ 0-1 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 14 | Sun 12 Nov | 214-0 v 1 FC Union BerlinBayer 04 Leverkusen 4-0 1 FC Union Berlin | German Bundesliga |
| 15 | Sat 25 Nov | 213-0 v Werder BremenWerder Bremen 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 16 | Thu 30 Nov | 212-0 v HäckenHäcken 0-2 Bayer 04 Leverkusen | UEFA Europa League Group H |
| 17 | Sun 3 Dec | 211-1 v Borussia DortmundBayer 04 Leverkusen 1-1 Borussia Dortmund | German Bundesliga |
| 18 | Sun 10 Dec | 211-1 v VfB StuttgartVfB Stuttgart 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 19 | Thu 14 Dec | 215-1 v MoldeBayer 04 Leverkusen 5-1 Molde | UEFA Europa League Group H |
| 20 | Wed 17 Jan | 213-0 v TanzaniaMorocco 3-0 Tanzania | Africa Cup of Nations Group F |
| 21 | Sun 21 Jan | 21 1-1 v DR CongoMorocco 1-1 DR Congo | Africa Cup of Nations Group F |
| 22 | Wed 24 Jan | 211-0 v ZambiaZambia 0-1 Morocco | Africa Cup of Nations Group F |
| 23 | Tue 30 Jan | 210-2 v South AfricaMorocco 0-2 South Africa | Africa Cup of Nations Round of 16 |
| 24 | Sat 10 Feb | 21 3-0 v Bayern MunichBayer 04 Leverkusen 3-0 Bayern Munich | German Bundesliga |
| 25 | Sat 17 Feb | 212-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 Bayer 04 Leverkusen | German Bundesliga |
| 26 | Fri 23 Feb | 212-1 v Mainz 05Bayer 04 Leverkusen 2-1 Mainz 05 | German Bundesliga |
| 27 | Sun 3 Mar | 212-0 v 1 FC Köln1 FC Köln 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 28 | Thu 7 Mar | 212-2 v FK QarabağFK Qarabağ 2-2 Bayer 04 Leverkusen | UEFA Europa League Round of 16 |
| 29 | Sun 10 Mar | 21 2-0 v VfL WolfsburgBayer 04 Leverkusen 2-0 VfL Wolfsburg | German Bundesliga |
| 30 | Thu 14 Mar | 213-2 v FK QarabağBayer 04 Leverkusen 3-2 FK Qarabağ | UEFA Europa League Round of 16 |
| 31 | Sun 17 Mar | 213-2 v SC FreiburgSC Freiburg 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 32 | Tue 26 Mar | 0-0 v MauritaniaMorocco 0-0 Mauritania | International Friendly |
| 33 | Sat 30 Mar | 212-1 v 1899 HoffenheimBayer 04 Leverkusen 2-1 1899 Hoffenheim | German Bundesliga |
| 34 | Sat 6 Apr | 21 1-0 v 1 FC Union Berlin1 FC Union Berlin 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 35 | Thu 11 Apr | 212-0 v West Ham UnitedBayer 04 Leverkusen 2-0 West Ham United | UEFA Europa League Quarter Final |
| 36 | Sun 14 Apr | 21 5-0 v Werder BremenBayer 04 Leverkusen 5-0 Werder Bremen | German Bundesliga |
| 37 | Thu 18 Apr | 21 1-1 v West Ham UnitedWest Ham United 1-1 Bayer 04 Leverkusen | UEFA Europa League Quarter Final |
| 38 | Sat 27 Apr | 212-2 v VfB StuttgartBayer 04 Leverkusen 2-2 VfB Stuttgart | German Bundesliga |
| 39 | Thu 2 May | 212-0 v RomaRoma 0-2 Bayer 04 Leverkusen | UEFA Europa League Semi Final |
| 40 | Thu 9 May | 212-2 v RomaBayer 04 Leverkusen 2-2 Roma | UEFA Europa League Semi Final |
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