| 1 | Sat 12 Sep 2020 | 41-0 v MechelenMechelen 0-1 KV Oostende |
| 2 | Sat 19 Sep 2020 | 43-1 v Oud-Heverlee LeuvenKV Oostende 3-1 Oud-Heverlee Leuven |
| 3 | Sun 4 Oct 2020 | 43-0 v Royal Excel MouscronKV Oostende 3-0 Royal Excel Mouscron |
| 4 | Sun 25 Oct 2020 | 43-0 v SV Zulte WaregemKV Oostende 3-0 SV Zulte Waregem |
| 5 | Sun 1 Nov 2020 | 40-1 v Standard LiègeStandard Liège 1-0 KV Oostende |
| 6 | Sun 8 Nov 2020 | 41-3 v Club BruggeKV Oostende 1-3 Club Brugge |
| 7 | Sat 21 Nov 2020 | 41-1 v Royal AntwerpKV Oostende 1-1 Royal Antwerp |
| 8 | Tue 24 Nov 2020 | 40-2 v Waasland-BeverenWaasland-Beveren 2-0 KV Oostende |
| 9 | Sun 29 Nov 2020 | 4 1-3 v KV KortrijkKV Kortrijk 3-1 KV Oostende |
| 10 | Sun 6 Dec 2020 | 42-1 v KAA GentKV Oostende 2-1 KAA Gent |
| 11 | Sat 12 Dec 2020 | 41-0 v Cercle BruggeCercle Brugge 0-1 KV Oostende |
| 12 | Tue 15 Dec 2020 | 41-2 v RSC AnderlechtRSC Anderlecht 2-1 KV Oostende |
| 13 | Sat 26 Dec 2020 | 42-1 v Oud-Heverlee LeuvenOud-Heverlee Leuven 1-2 KV Oostende |
| 14 | Sat 9 Jan 2021 | 43-2 v Sporting de CharleroiKV Oostende 3-2 Sporting de Charleroi |
| 15 | Tue 12 Jan 2021 | 41-1 v KAS EupenKV Oostende 1-1 KAS Eupen |
| 16 | Sat 16 Jan 2021 | 4 2-1 v KV KortrijkKV Oostende 2-1 KV Kortrijk |
| 17 | Wed 20 Jan 2021 | 41-2 v Club BruggeClub Brugge 2-1 KV Oostende |
| 18 | Sat 23 Jan 2021 | 4 2-1 v Royal AntwerpRoyal Antwerp 1-2 KV Oostende |
| 19 | Thu 28 Jan 2021 | 42-2 v Standard LiègeKV Oostende 2-2 Standard Liège |
| 20 | Wed 17 Feb 2021 | 43-1 v KRC GenkKV Oostende 3-1 KRC Genk |
| 21 | Sat 20 Feb 2021 | 41-1 v KAS EupenKAS Eupen 1-1 KV Oostende |
| 22 | Sat 27 Feb 2021 | 42-0 v MechelenKV Oostende 2-0 Mechelen |
| 23 | Mon 8 Mar 2021 | 40-1 v KAA GentKAA Gent 1-0 KV Oostende |
| 24 | Sat 20 Mar 2021 | 41-0 v Royal Excel MouscronRoyal Excel Mouscron 0-1 KV Oostende |
| 25 | Sat 3 Apr 2021 | 40-2 v Waasland-BeverenKV Oostende 0-2 Waasland-Beveren |
| 26 | Sun 11 Apr 2021 | 42-1 v Germinal BeerschotGerminal Beerschot 1-2 KV Oostende |
| 27 | Sun 18 Apr 2021 | 4 1-1 v Cercle BruggeKV Oostende 1-1 Cercle Brugge |
| 28 | Sat 1 May 2021 | 46-2 v Standard LiègeKV Oostende 6-2 Standard Liège |
| 29 | Sun 9 May 2021 | 43-5 v MechelenMechelen 5-3 KV Oostende |
| 30 | Sun 16 May 2021 | 40-4 v KAA GentKV Oostende 0-4 KAA Gent |
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