| 1 | Sat 15 Aug 2020 | 7 0-1 v Sporting de CharleroiSporting de Charleroi 1-0 KV Oostende |
| 2 | Mon 24 Aug 2020 | 7 0-0 v Sint-Truidense VVSint-Truidense VV 0-0 KV Oostende |
| 3 | Fri 28 Aug 2020 | 72-2 v RSC AnderlechtKV Oostende 2-2 RSC Anderlecht |
| 4 | Sat 12 Sep 2020 | 71-0 v MechelenMechelen 0-1 KV Oostende |
| 5 | Sat 19 Sep 2020 | 7 3-1 v Oud-Heverlee LeuvenKV Oostende 3-1 Oud-Heverlee Leuven |
| 6 | Mon 28 Sep 2020 | 7 2-2 v KRC GenkKRC Genk 2-2 KV Oostende |
| 7 | Sun 25 Oct 2020 | 73-0 v SV Zulte WaregemKV Oostende 3-0 SV Zulte Waregem |
| 8 | Sun 1 Nov 2020 | 70-1 v Standard LiègeStandard Liège 1-0 KV Oostende |
| 9 | Sun 8 Nov 2020 | 71-3 v Club BruggeKV Oostende 1-3 Club Brugge |
| 10 | Sat 21 Nov 2020 | 71-1 v Royal AntwerpKV Oostende 1-1 Royal Antwerp |
| 11 | Tue 24 Nov 2020 | 70-2 v Waasland-BeverenWaasland-Beveren 2-0 KV Oostende |
| 12 | Sun 29 Nov 2020 | 71-3 v KV KortrijkKV Kortrijk 3-1 KV Oostende |
| 13 | Sun 6 Dec 2020 | 7 2-1 v KAA GentKV Oostende 2-1 KAA Gent |
| 14 | Sat 12 Dec 2020 | 71-0 v Cercle BruggeCercle Brugge 0-1 KV Oostende |
| 15 | Tue 15 Dec 2020 | 71-2 v RSC AnderlechtRSC Anderlecht 2-1 KV Oostende |
| 16 | Sat 26 Dec 2020 | 72-1 v Oud-Heverlee LeuvenOud-Heverlee Leuven 1-2 KV Oostende |
| 17 | Sat 9 Jan 2021 | 73-2 v Sporting de CharleroiKV Oostende 3-2 Sporting de Charleroi |
| 18 | Tue 12 Jan 2021 | 71-1 v KAS EupenKV Oostende 1-1 KAS Eupen |
| 19 | Sat 16 Jan 2021 | 72-1 v KV KortrijkKV Oostende 2-1 KV Kortrijk |
| 20 | Wed 20 Jan 2021 | 71-2 v Club BruggeClub Brugge 2-1 KV Oostende |
| 21 | Sat 23 Jan 2021 | 72-1 v Royal AntwerpRoyal Antwerp 1-2 KV Oostende |
| 22 | Thu 28 Jan 2021 | 72-2 v Standard LiègeKV Oostende 2-2 Standard Liège |
| 23 | Sun 31 Jan 2021 | 71-2 v SV Zulte WaregemSV Zulte Waregem 2-1 KV Oostende |
| 24 | Sat 6 Feb 2021 | 73-1 v Sint-Truidense VVKV Oostende 3-1 Sint-Truidense VV |
| 25 | Wed 17 Feb 2021 | 73-1 v KRC GenkKV Oostende 3-1 KRC Genk |
| 26 | Sat 20 Feb 2021 | 71-1 v KAS EupenKAS Eupen 1-1 KV Oostende |
| 27 | Sat 27 Feb 2021 | 72-0 v MechelenKV Oostende 2-0 Mechelen |
| 28 | Mon 8 Mar 2021 | 70-1 v KAA GentKAA Gent 1-0 KV Oostende |
| 29 | Sat 20 Mar 2021 | 71-0 v Royal Excel MouscronRoyal Excel Mouscron 0-1 KV Oostende |
| 30 | Sat 3 Apr 2021 | 7 0-2 v Waasland-BeverenKV Oostende 0-2 Waasland-Beveren |
| 31 | Thu 13 May 2021 | 7 1-2 v KAA GentKAA Gent 2-1 KV Oostende |
| 32 | Sun 16 May 2021 | 70-4 v KAA GentKV Oostende 0-4 KAA Gent |
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