| 1 | Sat 26 Aug | 41-1 v VfL BochumVfL Bochum 1-1 Borussia Dortmund | German Bundesliga |
| 2 | Fri 1 Sep | 42-2 v 1 FC HeidenheimBorussia Dortmund 2-2 1 FC Heidenheim | German Bundesliga |
| 3 | Sat 16 Sep | 44-2 v SC FreiburgSC Freiburg 2-4 Borussia Dortmund | German Bundesliga |
| 4 | Tue 19 Sep | 4 0-2 v Paris St GermainParis St Germain 2-0 Borussia Dortmund | UEFA Champions League Group F |
| 5 | Sat 23 Sep | 41-0 v VfL WolfsburgBorussia Dortmund 1-0 VfL Wolfsburg | German Bundesliga |
| 6 | Fri 29 Sep | 43-1 v 1899 Hoffenheim1899 Hoffenheim 1-3 Borussia Dortmund | German Bundesliga |
| 7 | Wed 4 Oct | 4 0-0 v AC MilanBorussia Dortmund 0-0 AC Milan | UEFA Champions League Group F |
| 8 | Sat 7 Oct | 44-2 v 1 FC Union BerlinBorussia Dortmund 4-2 1 FC Union Berlin | German Bundesliga |
| 9 | Fri 20 Oct | 41-0 v Werder BremenBorussia Dortmund 1-0 Werder Bremen | German Bundesliga |
| 10 | Wed 25 Oct | 41-0 v Newcastle UnitedNewcastle United 0-1 Borussia Dortmund | UEFA Champions League Group F |
| 11 | Sun 29 Oct | 43-3 v Eintracht FrankfurtEintracht Frankfurt 3-3 Borussia Dortmund | German Bundesliga |
| 12 | Sat 4 Nov | 40-4 v Bayern MunichBorussia Dortmund 0-4 Bayern Munich | German Bundesliga |
| 13 | Tue 7 Nov | 42-0 v Newcastle UnitedBorussia Dortmund 2-0 Newcastle United | UEFA Champions League Group F |
| 14 | Sat 11 Nov | 41-2 v VfB StuttgartVfB Stuttgart 2-1 Borussia Dortmund | German Bundesliga |
| 15 | Sat 25 Nov | 44-2 v Borussia MönchengladbachBorussia Dortmund 4-2 Borussia Mönchengladbach | German Bundesliga |
| 16 | Tue 28 Nov | 43-1 v AC MilanAC Milan 1-3 Borussia Dortmund | UEFA Champions League Group F |
| 17 | Sun 3 Dec | 41-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-1 Borussia Dortmund | German Bundesliga |
| 18 | Sat 9 Dec | 42-3 v RB LeipzigBorussia Dortmund 2-3 RB Leipzig | German Bundesliga |
| 19 | Wed 13 Dec | 41-1 v Paris St GermainBorussia Dortmund 1-1 Paris St Germain | UEFA Champions League Group F |
| 20 | Sat 16 Dec | 41-1 v FC AugsburgFC Augsburg 1-1 Borussia Dortmund | German Bundesliga |
| 21 | Tue 19 Dec | 41-1 v Mainz 05Borussia Dortmund 1-1 Mainz 05 | German Bundesliga |
| 22 | Sat 13 Jan | 43-0 v Darmstadt 98Darmstadt 98 0-3 Borussia Dortmund | German Bundesliga |
| 23 | Sat 20 Jan | 44-0 v 1 FC Köln1 FC Köln 0-4 Borussia Dortmund | German Bundesliga |
| 24 | Sun 28 Jan | 43-1 v VfL BochumBorussia Dortmund 3-1 VfL Bochum | German Bundesliga |
| 25 | Fri 2 Feb | 40-0 v 1 FC Heidenheim1 FC Heidenheim 0-0 Borussia Dortmund | German Bundesliga |
| 26 | Fri 9 Feb | 43-0 v SC FreiburgBorussia Dortmund 3-0 SC Freiburg | German Bundesliga |
| 27 | Sat 17 Feb | 41-1 v VfL WolfsburgVfL Wolfsburg 1-1 Borussia Dortmund | German Bundesliga |
| 28 | Tue 20 Feb | 4 1-1 v PSV EindhovenPSV Eindhoven 1-1 Borussia Dortmund | UEFA Champions League Round of 16 |
| 29 | Sun 25 Feb | 42-3 v 1899 HoffenheimBorussia Dortmund 2-3 1899 Hoffenheim | German Bundesliga |
| 30 | Sat 2 Mar | 42-0 v 1 FC Union Berlin1 FC Union Berlin 0-2 Borussia Dortmund | German Bundesliga |
| 31 | Sat 9 Mar | 4 2-1 v Werder BremenWerder Bremen 1-2 Borussia Dortmund | German Bundesliga |
| 32 | Sun 17 Mar | 43-1 v Eintracht FrankfurtBorussia Dortmund 3-1 Eintracht Frankfurt | German Bundesliga |
| 33 | Sat 30 Mar | 42-0 v Bayern MunichBayern Munich 0-2 Borussia Dortmund | German Bundesliga |
| 34 | Sat 6 Apr | 40-1 v VfB StuttgartBorussia Dortmund 0-1 VfB Stuttgart | German Bundesliga |
| 35 | Wed 10 Apr | 41-2 v Atlético MadridAtlético Madrid 2-1 Borussia Dortmund | UEFA Champions League Quarter Final |
| 36 | Sat 13 Apr | 42-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 Borussia Dortmund | German Bundesliga |
| 37 | Tue 16 Apr | 44-2 v Atlético MadridBorussia Dortmund 4-2 Atlético Madrid | UEFA Champions League Quarter Final |
| 38 | Sun 21 Apr | 4 1-1 v Bayer 04 LeverkusenBorussia Dortmund 1-1 Bayer 04 Leverkusen | German Bundesliga |
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