| 1 | Sat 14 Aug 2021 | 12-1 v BurnleyBurnley 1-2 Brighton & Hove Albion | Premier League |
| 2 | Sat 21 Aug 2021 | 12-0 v WatfordBrighton & Hove Albion 2-0 Watford | Premier League |
| 3 | Sat 28 Aug 2021 | 10-2 v EvertonBrighton & Hove Albion 0-2 Everton | Premier League |
| 4 | Sat 11 Sep 2021 | 11-0 v BrentfordBrentford 0-1 Brighton & Hove Albion | Premier League |
| 5 | Sun 19 Sep 2021 | 1 2-1 v Leicester CityBrighton & Hove Albion 2-1 Leicester City | Premier League |
| 6 | Mon 27 Sep 2021 | 1 1-1 v Crystal PalaceCrystal Palace 1-1 Brighton & Hove Albion | Premier League |
| 7 | Sat 2 Oct 2021 | 10-0 v ArsenalBrighton & Hove Albion 0-0 Arsenal | Premier League |
| 8 | Sat 16 Oct 2021 | 10-0 v Norwich CityNorwich City 0-0 Brighton & Hove Albion | Premier League |
| 9 | Sat 23 Oct 2021 | 11-4 v Manchester CityBrighton & Hove Albion 1-4 Manchester City | Premier League |
| 10 | Sat 30 Oct 2021 | 12-2 v LiverpoolLiverpool 2-2 Brighton & Hove Albion | Premier League |
| 11 | Sat 6 Nov 2021 | 1 1-1 v Newcastle UnitedBrighton & Hove Albion 1-1 Newcastle United | Premier League |
| 12 | Sat 27 Nov 2021 | 10-0 v Leeds UnitedBrighton & Hove Albion 0-0 Leeds United | Premier League |
| 13 | Wed 1 Dec 2021 | 11-1 v West Ham UnitedWest Ham United 1-1 Brighton & Hove Albion | Premier League |
| 14 | Sat 4 Dec 2021 | 11-1 v SouthamptonSouthampton 1-1 Brighton & Hove Albion | Premier League |
| 15 | Wed 15 Dec 2021 | 10-1 v Wolverhampton WanderersBrighton & Hove Albion 0-1 Wolverhampton Wanderers | Premier League |
| 16 | Sun 26 Dec 2021 | 12-0 v BrentfordBrighton & Hove Albion 2-0 Brentford | Premier League |
| 17 | Wed 29 Dec 2021 | 11-1 v ChelseaChelsea 1-1 Brighton & Hove Albion | Premier League |
| 18 | Sun 2 Jan 2022 | 13-2 v EvertonEverton 2-3 Brighton & Hove Albion | Premier League |
| 19 | Fri 14 Jan 2022 | 11-1 v Crystal PalaceBrighton & Hove Albion 1-1 Crystal Palace | Premier League |
| 20 | Tue 18 Jan 2022 | 11-1 v ChelseaBrighton & Hove Albion 1-1 Chelsea | Premier League |
| 21 | Sun 23 Jan 2022 | 11-1 v Leicester CityLeicester City 1-1 Brighton & Hove Albion | Premier League |
| 22 | Sat 5 Feb 2022 | 11-3 v Tottenham HotspurTottenham Hotspur 3-1 Brighton & Hove Albion | Emirates FA Cup Fourth Round |
| 23 | Sat 12 Feb 2022 | 12-0 v WatfordWatford 0-2 Brighton & Hove Albion | Premier League |
| 24 | Tue 15 Feb 2022 | 10-2 v Manchester UnitedManchester United 2-0 Brighton & Hove Albion | Premier League |
| 25 | Sat 19 Feb 2022 | 10-3 v BurnleyBrighton & Hove Albion 0-3 Burnley | Premier League |
| 26 | Sat 26 Feb 2022 | 10-2 v Aston VillaBrighton & Hove Albion 0-2 Aston Villa | Premier League |
| 27 | Sat 5 Mar 2022 | 11-2 v Newcastle UnitedNewcastle United 2-1 Brighton & Hove Albion | Premier League |
| 28 | Sat 12 Mar 2022 | 10-2 v LiverpoolBrighton & Hove Albion 0-2 Liverpool | Premier League |
| 29 | Wed 16 Mar 2022 | 10-2 v Tottenham HotspurBrighton & Hove Albion 0-2 Tottenham Hotspur | Premier League |
| 30 | Sat 2 Apr 2022 | 10-0 v Norwich CityBrighton & Hove Albion 0-0 Norwich City | Premier League |
| 31 | Sat 9 Apr 2022 | 1 2-1 v ArsenalArsenal 1-2 Brighton & Hove Albion | Premier League |
| 32 | Sat 16 Apr 2022 | 1 1-0 v Tottenham HotspurTottenham Hotspur 0-1 Brighton & Hove Albion | Premier League |
| 33 | Wed 20 Apr 2022 | 10-3 v Manchester CityManchester City 3-0 Brighton & Hove Albion | Premier League |
| 34 | Sun 24 Apr 2022 | 12-2 v SouthamptonBrighton & Hove Albion 2-2 Southampton | Premier League |
| 35 | Sat 30 Apr 2022 | 13-0 v Wolverhampton WanderersWolverhampton Wanderers 0-3 Brighton & Hove Albion | Premier League |
| 36 | Sat 7 May 2022 | 14-0 v Manchester UnitedBrighton & Hove Albion 4-0 Manchester United | Premier League |
| 37 | Sun 15 May 2022 | 11-1 v Leeds UnitedLeeds United 1-1 Brighton & Hove Albion | Premier League |
| 38 | Sun 22 May 2022 | 13-1 v West Ham UnitedBrighton & Hove Albion 3-1 West Ham United | Premier League |
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