| 1 | Tue 17 Sep | 43-0 v Young BoysYoung Boys 0-3 Aston Villa |
| 2 | Wed 2 Oct | 41-0 v Bayern MunichAston Villa 1-0 Bayern Munich |
| 3 | Tue 22 Oct | 42-0 v BolognaAston Villa 2-0 Bologna |
| 4 | Wed 6 Nov | 4 0-1 v Club BruggeClub Brugge 1-0 Aston Villa |
| 5 | Tue 10 Dec | 43-2 v RB LeipzigRB Leipzig 2-3 Aston Villa |
| 6 | Tue 21 Jan | 40-1 v MonacoMonaco 1-0 Aston Villa |
| 7 | Wed 29 Jan | 44-2 v CelticAston Villa 4-2 Celtic |
| 8 | Tue 4 Mar | 43-1 v Club BruggeClub Brugge 1-3 Aston Villa |
| 9 | Wed 12 Mar | 43-0 v Club BruggeAston Villa 3-0 Club Brugge |
| 10 | Wed 9 Apr | 41-3 v Paris St GermainParis St Germain 3-1 Aston Villa |
| 11 | Tue 15 Apr | 43-2 v Paris St GermainAston Villa 3-2 Paris St Germain |
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