| 1 | Sat 11 Sep 2021 | 110-3 v AFC BournemouthAFC Bournemouth 3-0 Barnsley |
| 2 | Wed 15 Sep 2021 | 111-1 v Stoke CityStoke City 1-1 Barnsley |
| 3 | Sat 18 Sep 2021 | 110-0 v Blackburn RoversBarnsley 0-0 Blackburn Rovers |
| 4 | Sat 25 Sep 2021 | 11 0-1 v BlackpoolBlackpool 1-0 Barnsley |
| 5 | Wed 29 Sep 2021 | 111-3 v Nottingham ForestBarnsley 1-3 Nottingham Forest |
| 6 | Sat 2 Oct 2021 | 110-1 v MillwallBarnsley 0-1 Millwall |
| 7 | Sat 16 Oct 2021 | 110-1 v ReadingReading 1-0 Barnsley |
| 8 | Wed 20 Oct 2021 | 110-2 v MiddlesbroughMiddlesbrough 2-0 Barnsley |
| 9 | Sun 24 Oct 2021 | 112-3 v Sheffield UnitedBarnsley 2-3 Sheffield United |
| 10 | Sat 30 Oct 2021 | 111-2 v Bristol CityBristol City 2-1 Barnsley |
| 11 | Wed 3 Nov 2021 | 112-1 v Derby CountyBarnsley 2-1 Derby County |
| 12 | Sat 6 Nov 2021 | 110-2 v Hull CityBarnsley 0-2 Hull City |
| 13 | Sat 20 Nov 2021 | 111-4 v FulhamFulham 4-1 Barnsley |
| 14 | Wed 24 Nov 2021 | 110-2 v Swansea CityBarnsley 0-2 Swansea City |
| 15 | Sat 4 Dec 2021 | 111-1 v Huddersfield TownBarnsley 1-1 Huddersfield Town |
| 16 | Sat 11 Dec 2021 | 111-2 v Preston North EndPreston North End 2-1 Barnsley |
| 17 | Fri 17 Dec 2021 | 110-0 v West Bromwich AlbionBarnsley 0-0 West Bromwich Albion |
| 18 | Wed 29 Dec 2021 | 111-2 v Blackburn RoversBlackburn Rovers 2-1 Barnsley |
| 19 | Sat 22 Jan 2022 | 111-2 v Birmingham CityBirmingham City 2-1 Barnsley |
| 20 | Tue 25 Jan 2022 | 110-3 v Nottingham ForestNottingham Forest 3-0 Barnsley |
| 21 | Sat 29 Jan 2022 | 110-1 v AFC BournemouthBarnsley 0-1 AFC Bournemouth |
| 22 | Wed 2 Feb 2022 | 110-1 v Cardiff CityBarnsley 0-1 Cardiff City |
| 23 | Sat 19 Mar 2022 | 110-2 v Sheffield UnitedSheffield United 2-0 Barnsley |
| 24 | Sat 9 Apr 2022 | 111-4 v MillwallMillwall 4-1 Barnsley |
| 25 | Fri 22 Apr 2022 | 111-2 v Huddersfield TownHuddersfield Town 2-1 Barnsley |
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