| 1 | Sat 7 Aug 2021 | 41-1 v Cardiff CityCardiff City 1-1 Barnsley |
| 2 | Sat 14 Aug 2021 | 4 1-0 v Coventry CityBarnsley 1-0 Coventry City |
| 3 | Tue 17 Aug 2021 | 40-1 v Luton TownBarnsley 0-1 Luton Town |
| 4 | Sat 21 Aug 2021 | 4 2-2 v Queens Park RangersQueens Park Rangers 2-2 Barnsley |
| 5 | Sat 28 Aug 2021 | 4 1-1 v Birmingham CityBarnsley 1-1 Birmingham City |
| 6 | Sat 11 Sep 2021 | 40-3 v AFC BournemouthAFC Bournemouth 3-0 Barnsley |
| 7 | Wed 15 Sep 2021 | 41-1 v Stoke CityStoke City 1-1 Barnsley |
| 8 | Sat 18 Sep 2021 | 40-0 v Blackburn RoversBarnsley 0-0 Blackburn Rovers |
| 9 | Sat 25 Sep 2021 | 40-1 v BlackpoolBlackpool 1-0 Barnsley |
| 10 | Wed 29 Sep 2021 | 41-3 v Nottingham ForestBarnsley 1-3 Nottingham Forest |
| 11 | Sat 2 Oct 2021 | 40-1 v MillwallBarnsley 0-1 Millwall |
| 12 | Wed 20 Oct 2021 | 40-2 v MiddlesbroughMiddlesbrough 2-0 Barnsley |
| 13 | Sun 24 Oct 2021 | 42-3 v Sheffield UnitedBarnsley 2-3 Sheffield United |
| 14 | Wed 3 Nov 2021 | 42-1 v Derby CountyBarnsley 2-1 Derby County |
| 15 | Sat 6 Nov 2021 | 40-2 v Hull CityBarnsley 0-2 Hull City |
| 16 | Sat 20 Nov 2021 | 41-4 v FulhamFulham 4-1 Barnsley |
| 17 | Wed 24 Nov 2021 | 40-2 v Swansea CityBarnsley 0-2 Swansea City |
| 18 | Sat 27 Nov 2021 | 40-0 v Peterborough UnitedPeterborough United 0-0 Barnsley |
| 19 | Sat 4 Dec 2021 | 41-1 v Huddersfield TownBarnsley 1-1 Huddersfield Town |
| 20 | Sat 11 Dec 2021 | 41-2 v Preston North EndPreston North End 2-1 Barnsley |
| 21 | Fri 17 Dec 2021 | 40-0 v West Bromwich AlbionBarnsley 0-0 West Bromwich Albion |
| 22 | Wed 29 Dec 2021 | 41-2 v Blackburn RoversBlackburn Rovers 2-1 Barnsley |
| 23 | Sat 22 Jan 2022 | 41-2 v Birmingham CityBirmingham City 2-1 Barnsley |
| 24 | Tue 25 Jan 2022 | 40-3 v Nottingham ForestNottingham Forest 3-0 Barnsley |
| 25 | Sat 29 Jan 2022 | 40-1 v AFC BournemouthBarnsley 0-1 AFC Bournemouth |
| 26 | Wed 2 Feb 2022 | 40-1 v Cardiff CityBarnsley 0-1 Cardiff City |
| 27 | Tue 8 Feb 2022 | 41-2 v Luton TownLuton Town 2-1 Barnsley |
| 28 | Sat 12 Feb 2022 | 41-0 v Queens Park RangersBarnsley 1-0 Queens Park Rangers |
| 29 | Sat 19 Feb 2022 | 40-1 v Coventry CityCoventry City 1-0 Barnsley |
| 30 | Tue 22 Feb 2022 | 42-0 v Hull CityHull City 0-2 Barnsley |
| 31 | Sat 26 Feb 2022 | 43-2 v MiddlesbroughBarnsley 3-2 Middlesbrough |
| 32 | Sat 5 Mar 2022 | 40-2 v Derby CountyDerby County 2-0 Barnsley |
| 33 | Tue 8 Mar 2022 | 41-1 v Stoke CityBarnsley 1-1 Stoke City |
| 34 | Tue 15 Mar 2022 | 42-0 v Bristol CityBarnsley 2-0 Bristol City |
| 35 | Sat 19 Mar 2022 | 40-2 v Sheffield UnitedSheffield United 2-0 Barnsley |
| 36 | Sat 2 Apr 2022 | 41-1 v ReadingBarnsley 1-1 Reading |
| 37 | Sat 9 Apr 2022 | 41-4 v MillwallMillwall 4-1 Barnsley |
| 38 | Fri 15 Apr 2022 | 41-1 v Swansea CitySwansea City 1-1 Barnsley |
| 39 | Mon 18 Apr 2022 | 40-2 v Peterborough UnitedBarnsley 0-2 Peterborough United |
| 40 | Fri 22 Apr 2022 | 41-2 v Huddersfield TownHuddersfield Town 2-1 Barnsley |
| 41 | Tue 26 Apr 2022 | 40-2 v BlackpoolBarnsley 0-2 Blackpool |
| 42 | Sat 30 Apr 2022 | 41-3 v Preston North EndBarnsley 1-3 Preston North End |
| 43 | Sat 7 May 2022 | 40-4 v West Bromwich AlbionWest Bromwich Albion 4-0 Barnsley |
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