| 1 | Sat 7 Aug 2021 | 91-1 v Cardiff CityCardiff City 1-1 Barnsley |
| 2 | Sat 14 Aug 2021 | 9 1-0 v Coventry CityBarnsley 1-0 Coventry City |
| 3 | Tue 17 Aug 2021 | 90-1 v Luton TownBarnsley 0-1 Luton Town |
| 4 | Sat 21 Aug 2021 | 92-2 v Queens Park RangersQueens Park Rangers 2-2 Barnsley |
| 5 | Sat 28 Aug 2021 | 91-1 v Birmingham CityBarnsley 1-1 Birmingham City |
| 6 | Sat 11 Sep 2021 | 90-3 v AFC BournemouthAFC Bournemouth 3-0 Barnsley |
| 7 | Wed 15 Sep 2021 | 91-1 v Stoke CityStoke City 1-1 Barnsley |
| 8 | Sat 18 Sep 2021 | 90-0 v Blackburn RoversBarnsley 0-0 Blackburn Rovers |
| 9 | Sat 25 Sep 2021 | 90-1 v BlackpoolBlackpool 1-0 Barnsley |
| 10 | Wed 29 Sep 2021 | 91-3 v Nottingham ForestBarnsley 1-3 Nottingham Forest |
| 11 | Sat 2 Oct 2021 | 90-1 v MillwallBarnsley 0-1 Millwall |
| 12 | Sat 16 Oct 2021 | 90-1 v ReadingReading 1-0 Barnsley |
| 13 | Wed 20 Oct 2021 | 90-2 v MiddlesbroughMiddlesbrough 2-0 Barnsley |
| 14 | Sun 24 Oct 2021 | 92-3 v Sheffield UnitedBarnsley 2-3 Sheffield United |
| 15 | Sat 30 Oct 2021 | 91-2 v Bristol CityBristol City 2-1 Barnsley |
| 16 | Wed 3 Nov 2021 | 9 2-1 v Derby CountyBarnsley 2-1 Derby County |
| 17 | Sat 6 Nov 2021 | 90-2 v Hull CityBarnsley 0-2 Hull City |
| 18 | Sat 20 Nov 2021 | 91-4 v FulhamFulham 4-1 Barnsley |
| 19 | Wed 24 Nov 2021 | 90-2 v Swansea CityBarnsley 0-2 Swansea City |
| 20 | Sat 27 Nov 2021 | 90-0 v Peterborough UnitedPeterborough United 0-0 Barnsley |
| 21 | Sat 4 Dec 2021 | 91-1 v Huddersfield TownBarnsley 1-1 Huddersfield Town |
| 22 | Sat 11 Dec 2021 | 9 1-2 v Preston North EndPreston North End 2-1 Barnsley |
| 23 | Fri 15 Apr 2022 | 91-1 v Swansea CitySwansea City 1-1 Barnsley |
| 24 | Mon 18 Apr 2022 | 90-2 v Peterborough UnitedBarnsley 0-2 Peterborough United |
| 25 | Fri 22 Apr 2022 | 91-2 v Huddersfield TownHuddersfield Town 2-1 Barnsley |
| 26 | Tue 26 Apr 2022 | 90-2 v BlackpoolBarnsley 0-2 Blackpool |
| 27 | Sat 30 Apr 2022 | 91-3 v Preston North EndBarnsley 1-3 Preston North End |
| 28 | Sat 7 May 2022 | 90-4 v West Bromwich AlbionWest Bromwich Albion 4-0 Barnsley |
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