| 1 | Fri 6 Aug 2021 | 6 2-2 v West Bromwich AlbionAFC Bournemouth 2-2 West Bromwich Albion |
| 2 | Sat 14 Aug 2021 | 6 2-1 v Nottingham ForestNottingham Forest 1-2 AFC Bournemouth |
| 3 | Wed 18 Aug 2021 | 62-0 v Birmingham CityBirmingham City 0-2 AFC Bournemouth |
| 4 | Sat 21 Aug 2021 | 62-2 v BlackpoolAFC Bournemouth 2-2 Blackpool |
| 5 | Sat 28 Aug 2021 | 60-0 v Hull CityHull City 0-0 AFC Bournemouth |
| 6 | Tue 14 Sep 2021 | 62-1 v Queens Park RangersAFC Bournemouth 2-1 Queens Park Rangers |
| 7 | Sat 18 Sep 2021 | 61-0 v Cardiff CityCardiff City 0-1 AFC Bournemouth |
| 8 | Sat 25 Sep 2021 | 62-1 v Luton TownAFC Bournemouth 2-1 Luton Town |
| 9 | Sat 2 Oct 2021 | 62-1 v Sheffield UnitedAFC Bournemouth 2-1 Sheffield United |
| 10 | Sat 30 Oct 2021 | 6 2-0 v ReadingReading 0-2 AFC Bournemouth |
| 11 | Wed 3 Nov 2021 | 6 1-2 v Preston North EndAFC Bournemouth 1-2 Preston North End |
| 12 | Sun 21 Nov 2021 | 62-3 v Derby CountyDerby County 3-2 AFC Bournemouth |
| 13 | Wed 24 Nov 2021 | 61-1 v MillwallMillwall 1-1 AFC Bournemouth |
| 14 | Sat 27 Nov 2021 | 6 2-2 v Coventry CityAFC Bournemouth 2-2 Coventry City |
| 15 | Fri 3 Dec 2021 | 61-1 v FulhamFulham 1-1 AFC Bournemouth |
| 16 | Mon 27 Dec 2021 | 6 1-0 v Queens Park RangersQueens Park Rangers 0-1 AFC Bournemouth |
| 17 | Sat 22 Jan 2022 | 60-1 v Hull CityAFC Bournemouth 0-1 Hull City |
| 18 | Sat 26 Feb 2022 | 6 2-1 v Stoke CityAFC Bournemouth 2-1 Stoke City |
| 19 | Mon 18 Apr 2022 | 63-0 v Coventry CityCoventry City 0-3 AFC Bournemouth |
| 20 | Sat 30 Apr 2022 | 63-0 v Blackburn RoversBlackburn Rovers 0-3 AFC Bournemouth |
| 21 | Tue 3 May 2022 | 61-0 v Nottingham ForestAFC Bournemouth 1-0 Nottingham Forest |
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