| 1 | Sun 8 Aug 2021 | 8 1-1 v MiddlesbroughFulham 1-1 Middlesbrough |
| 2 | Sat 14 Aug 2021 | 8 5-1 v Huddersfield TownHuddersfield Town 1-5 Fulham |
| 3 | Sat 28 Aug 2021 | 83-0 v Stoke CityFulham 3-0 Stoke City |
| 4 | Wed 15 Sep 2021 | 84-1 v Birmingham CityBirmingham City 1-4 Fulham |
| 5 | Sat 18 Sep 2021 | 8 1-2 v ReadingFulham 1-2 Reading |
| 6 | Sat 25 Sep 2021 | 81-1 v Bristol CityBristol City 1-1 Fulham |
| 7 | Wed 29 Sep 2021 | 83-1 v Swansea CityFulham 3-1 Swansea City |
| 8 | Sat 2 Oct 2021 | 81-4 v Coventry CityCoventry City 4-1 Fulham |
| 9 | Sat 16 Oct 2021 | 84-1 v Queens Park RangersFulham 4-1 Queens Park Rangers |
| 10 | Wed 20 Oct 2021 | 82-0 v Cardiff CityFulham 2-0 Cardiff City |
| 11 | Sun 24 Oct 2021 | 8 4-0 v Nottingham ForestNottingham Forest 0-4 Fulham |
| 12 | Sat 30 Oct 2021 | 83-0 v West Bromwich AlbionFulham 3-0 West Bromwich Albion |
| 13 | Wed 3 Nov 2021 | 87-0 v Blackburn RoversBlackburn Rovers 0-7 Fulham |
| 14 | Sat 6 Nov 2021 | 81-0 v Peterborough UnitedPeterborough United 0-1 Fulham |
| 15 | Sat 20 Nov 2021 | 84-1 v BarnsleyFulham 4-1 Barnsley |
| 16 | Wed 24 Nov 2021 | 80-0 v Derby CountyFulham 0-0 Derby County |
| 17 | Sat 27 Nov 2021 | 81-1 v Preston North EndPreston North End 1-1 Fulham |
| 18 | Fri 3 Dec 2021 | 81-1 v AFC BournemouthFulham 1-1 AFC Bournemouth |
| 19 | Sat 11 Dec 2021 | 81-1 v Luton TownLuton Town 1-1 Fulham |
| 20 | Mon 20 Dec 2021 | 80-1 v Sheffield UnitedFulham 0-1 Sheffield United |
| 21 | Tue 11 Jan 2022 | 87-0 v ReadingReading 0-7 Fulham |
| 22 | Sat 15 Jan 2022 | 86-2 v Bristol CityFulham 6-2 Bristol City |
| 23 | Tue 18 Jan 2022 | 86-2 v Birmingham CityFulham 6-2 Birmingham City |
| 24 | Sat 29 Jan 2022 | 8 1-1 v BlackpoolFulham 1-1 Blackpool |
| 25 | Tue 8 Feb 2022 | 83-0 v MillwallFulham 3-0 Millwall |
| 26 | Sat 12 Feb 2022 | 81-0 v Hull CityHull City 0-1 Fulham |
| 27 | Sat 19 Feb 2022 | 81-2 v Huddersfield TownFulham 1-2 Huddersfield Town |
| 28 | Wed 23 Feb 2022 | 82-1 v Peterborough UnitedFulham 2-1 Peterborough United |
| 29 | Sat 26 Feb 2022 | 81-0 v Cardiff CityCardiff City 0-1 Fulham |
| 30 | Sat 5 Mar 2022 | 82-0 v Blackburn RoversFulham 2-0 Blackburn Rovers |
| 31 | Tue 8 Mar 2022 | 85-1 v Swansea CitySwansea City 1-5 Fulham |
| 32 | Sat 12 Mar 2022 | 81-1 v BarnsleyBarnsley 1-1 Fulham |
| 33 | Tue 15 Mar 2022 | 80-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Fulham |
| 34 | Sat 2 Apr 2022 | 82-0 v Queens Park RangersQueens Park Rangers 0-2 Fulham |
| 35 | Wed 6 Apr 2022 | 81-0 v MiddlesbroughMiddlesbrough 0-1 Fulham |
| 36 | Sun 10 Apr 2022 | 8 1-3 v Coventry CityFulham 1-3 Coventry City |
| 37 | Fri 15 Apr 2022 | 81-2 v Derby CountyDerby County 2-1 Fulham |
| 38 | Tue 19 Apr 2022 | 83-0 v Preston North EndFulham 3-0 Preston North End |
| 39 | Sat 23 Apr 2022 | 81-1 v AFC BournemouthAFC Bournemouth 1-1 Fulham |
| 40 | Tue 26 Apr 2022 | 80-1 v Nottingham ForestFulham 0-1 Nottingham Forest |
| 41 | Mon 2 May 2022 | 8 7-0 v Luton TownFulham 7-0 Luton Town |
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