| 1 | Sat 21 Aug 2021 | 331-2 v Huddersfield TownSheffield United 1-2 Huddersfield Town |
| 2 | Sat 28 Aug 2021 | 330-0 v Luton TownLuton Town 0-0 Sheffield United |
| 3 | Sat 11 Sep 2021 | 336-2 v Peterborough UnitedSheffield United 6-2 Peterborough United |
| 4 | Tue 14 Sep 2021 | 33 2-2 v Preston North EndSheffield United 2-2 Preston North End |
| 5 | Sat 18 Sep 2021 | 33 3-1 v Hull CityHull City 1-3 Sheffield United |
| 6 | Sat 25 Sep 2021 | 331-0 v Derby CountySheffield United 1-0 Derby County |
| 7 | Tue 28 Sep 2021 | 330-2 v MiddlesbroughMiddlesbrough 2-0 Sheffield United |
| 8 | Sat 15 Jan 2022 | 330-2 v Derby CountyDerby County 2-0 Sheffield United |
| 9 | Tue 18 Jan 2022 | 332-2 v Preston North EndPreston North End 2-2 Sheffield United |
| 10 | Sat 22 Jan 2022 | 332-0 v Luton TownSheffield United 2-0 Luton Town |
| 11 | Sat 29 Jan 2022 | 332-0 v Peterborough UnitedPeterborough United 0-2 Sheffield United |
| 12 | Fri 4 Feb 2022 | 332-1 v Birmingham CityBirmingham City 1-2 Sheffield United |
| 13 | Tue 15 Feb 2022 | 330-0 v Hull CitySheffield United 0-0 Hull City |
| 14 | Sat 19 Feb 2022 | 334-0 v Swansea CitySheffield United 4-0 Swansea City |
| 15 | Wed 23 Feb 2022 | 331-0 v Blackburn RoversSheffield United 1-0 Blackburn Rovers |
| 16 | Sat 26 Feb 2022 | 33 0-1 v MillwallMillwall 1-0 Sheffield United |
| 17 | Fri 4 Mar 2022 | 33 1-1 v Nottingham ForestSheffield United 1-1 Nottingham Forest |
| 18 | Tue 8 Mar 2022 | 334-1 v MiddlesbroughSheffield United 4-1 Middlesbrough |
| 19 | Sat 12 Mar 2022 | 331-4 v Coventry CityCoventry City 4-1 Sheffield United |
| 20 | Wed 16 Mar 2022 | 330-0 v BlackpoolBlackpool 0-0 Sheffield United |
| 21 | Sat 19 Mar 2022 | 332-0 v BarnsleySheffield United 2-0 Barnsley |
| 22 | Sat 2 Apr 2022 | 330-1 v Stoke CityStoke City 1-0 Sheffield United |
| 23 | Sat 14 May 2022 | 331-2 v Nottingham ForestSheffield United 1-2 Nottingham Forest |
| 24 | Tue 17 May 2022 | 332-1 v Nottingham ForestNottingham Forest 1-2 Sheffield United |
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