| 1 | Tue 17 Aug 2021 | 290-1 v Luton TownBarnsley 0-1 Luton Town |
| 2 | Sat 28 Aug 2021 | 291-1 v Birmingham CityBarnsley 1-1 Birmingham City |
| 3 | Wed 15 Sep 2021 | 29 1-1 v Stoke CityStoke City 1-1 Barnsley |
| 4 | Sat 18 Sep 2021 | 290-0 v Blackburn RoversBarnsley 0-0 Blackburn Rovers |
| 5 | Sat 25 Sep 2021 | 290-1 v BlackpoolBlackpool 1-0 Barnsley |
| 6 | Wed 29 Sep 2021 | 291-3 v Nottingham ForestBarnsley 1-3 Nottingham Forest |
| 7 | Sat 2 Oct 2021 | 29 0-1 v MillwallBarnsley 0-1 Millwall |
| 8 | Sat 16 Oct 2021 | 290-1 v ReadingReading 1-0 Barnsley |
| 9 | Wed 20 Oct 2021 | 290-2 v MiddlesbroughMiddlesbrough 2-0 Barnsley |
| 10 | Sun 24 Oct 2021 | 292-3 v Sheffield UnitedBarnsley 2-3 Sheffield United |
| 11 | Sat 30 Oct 2021 | 291-2 v Bristol CityBristol City 2-1 Barnsley |
| 12 | Wed 3 Nov 2021 | 292-1 v Derby CountyBarnsley 2-1 Derby County |
| 13 | Sat 6 Nov 2021 | 290-2 v Hull CityBarnsley 0-2 Hull City |
| 14 | Sat 20 Nov 2021 | 291-4 v FulhamFulham 4-1 Barnsley |
| 15 | Sat 27 Nov 2021 | 290-0 v Peterborough UnitedPeterborough United 0-0 Barnsley |
| 16 | Sat 4 Dec 2021 | 291-1 v Huddersfield TownBarnsley 1-1 Huddersfield Town |
| 17 | Sat 11 Dec 2021 | 291-2 v Preston North EndPreston North End 2-1 Barnsley |
| 18 | Wed 29 Dec 2021 | 291-2 v Blackburn RoversBlackburn Rovers 2-1 Barnsley |
| 19 | Sat 22 Jan 2022 | 291-2 v Birmingham CityBirmingham City 2-1 Barnsley |
| 20 | Tue 25 Jan 2022 | 290-3 v Nottingham ForestNottingham Forest 3-0 Barnsley |
| 21 | Sat 2 Apr 2022 | 291-1 v ReadingBarnsley 1-1 Reading |
| 22 | Sat 9 Apr 2022 | 291-4 v MillwallMillwall 4-1 Barnsley |
| 23 | Mon 18 Apr 2022 | 290-2 v Peterborough UnitedBarnsley 0-2 Peterborough United |
| 24 | Tue 26 Apr 2022 | 290-2 v BlackpoolBarnsley 0-2 Blackpool |
| 25 | Sat 30 Apr 2022 | 291-3 v Preston North EndBarnsley 1-3 Preston North End |
| 26 | Sat 7 May 2022 | 290-4 v West Bromwich AlbionWest Bromwich Albion 4-0 Barnsley |
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